Macrocyclic lactones and ectoparasites control in livestock: Efficacy, drug resistance and therapeutic challenges
Macrocyclic lactones (MLs) are the cornerstone of parasite control in livestock due to their broad-spectrum activity against endo (nematodes) and ecto (lice, ticks, mites) parasites. These molecules, introduced into the veterinary pharmaceutical market 40 years ago, have substantially improved anima...
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Elsevier
2024-12-01
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| Series: | International Journal for Parasitology: Drugs and Drug Resistance |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S221132072400040X |
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| author | A. Lifschitz S. Nava V. Miró C. Canton L. Alvarez C. Lanusse |
| author_facet | A. Lifschitz S. Nava V. Miró C. Canton L. Alvarez C. Lanusse |
| author_sort | A. Lifschitz |
| collection | DOAJ |
| description | Macrocyclic lactones (MLs) are the cornerstone of parasite control in livestock due to their broad-spectrum activity against endo (nematodes) and ecto (lice, ticks, mites) parasites. These molecules, introduced into the veterinary pharmaceutical market 40 years ago, have substantially improved animal welfare and productivity by offering extended high efficacy, reducing treatment frequency, and displaying a favorable safety profile. However, their widespread and intensive use has led to a significant challenge nowadays: the development of parasite resistance. This review focuses on the critical link between drug pharmacokinetics (variation in concentration profiles and exposure over time) and pharmacodynamics (drug efficacy) and the ability of both avermectin and milbemycin MLs families to control livestock ectoparasites. This review discusses the integrated assessment of drug behavior in the host, its diffusion into target parasites, and the impact of different pharmaceutical formulations on enhancing drug delivery to infection sites. These are considered critical research/development areas to optimize the use of MLs, preventing treatment failures and finally extending the lifespan of these essential pharmaceutical ingredients. Finally, the importance of the rational use of MLs, guided by parasite epidemiology and pharmacological knowledge, is emphasized as a key strategy to preserve the antiparasitic efficacy of these still very useful molecules. |
| format | Article |
| id | doaj-art-db90f4448a404745ba354d5bd8b8a609 |
| institution | Kabale University |
| issn | 2211-3207 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal for Parasitology: Drugs and Drug Resistance |
| spelling | doaj-art-db90f4448a404745ba354d5bd8b8a6092024-12-12T05:21:12ZengElsevierInternational Journal for Parasitology: Drugs and Drug Resistance2211-32072024-12-0126100559Macrocyclic lactones and ectoparasites control in livestock: Efficacy, drug resistance and therapeutic challengesA. Lifschitz0S. Nava1V. Miró2C. Canton3L. Alvarez4C. Lanusse5Laboratorio de Farmacología, Centro de Investigación Veterinaria de Tandil (CIVETAN), UNCPBA-CICPBA-CONICET, Campus Universitario, Tandil, Buenos Aires, Argentina; Universidad Nacional del Centro de la Provincia de Buenos Aires (UNCPBA), Facultad de Ciencias Veterinarias, Campus Universitario, Tandil, Buenos Aires, Argentina; Corresponding author. Laboratorio de Farmacología, Centro de Investigación Veterinaria de Tandil (CIVETAN), UNCPBA-CICPBA-CONICET, Campus Universitario, Tandil, Buenos Aires, Argentina.Instituto de Investigación de la Cadena Láctea (IdICaL)(INTA-CONICET), Instituto Nacional de Tecnología Agropecuaria, INTA E.E.A, Rafaela, Santa Fe, ArgentinaLaboratorio de Farmacología, Centro de Investigación Veterinaria de Tandil (CIVETAN), UNCPBA-CICPBA-CONICET, Campus Universitario, Tandil, Buenos Aires, Argentina; Universidad Nacional del Centro de la Provincia de Buenos Aires (UNCPBA), Facultad de Ciencias Veterinarias, Campus Universitario, Tandil, Buenos Aires, ArgentinaLaboratorio de Farmacología, Centro de Investigación Veterinaria de Tandil (CIVETAN), UNCPBA-CICPBA-CONICET, Campus Universitario, Tandil, Buenos Aires, Argentina; Universidad Nacional del Centro de la Provincia de Buenos Aires (UNCPBA), Facultad de Ciencias Veterinarias, Campus Universitario, Tandil, Buenos Aires, ArgentinaLaboratorio de Farmacología, Centro de Investigación Veterinaria de Tandil (CIVETAN), UNCPBA-CICPBA-CONICET, Campus Universitario, Tandil, Buenos Aires, Argentina; Universidad Nacional del Centro de la Provincia de Buenos Aires (UNCPBA), Facultad de Ciencias Veterinarias, Campus Universitario, Tandil, Buenos Aires, ArgentinaLaboratorio de Farmacología, Centro de Investigación Veterinaria de Tandil (CIVETAN), UNCPBA-CICPBA-CONICET, Campus Universitario, Tandil, Buenos Aires, Argentina; Universidad Nacional del Centro de la Provincia de Buenos Aires (UNCPBA), Facultad de Ciencias Veterinarias, Campus Universitario, Tandil, Buenos Aires, ArgentinaMacrocyclic lactones (MLs) are the cornerstone of parasite control in livestock due to their broad-spectrum activity against endo (nematodes) and ecto (lice, ticks, mites) parasites. These molecules, introduced into the veterinary pharmaceutical market 40 years ago, have substantially improved animal welfare and productivity by offering extended high efficacy, reducing treatment frequency, and displaying a favorable safety profile. However, their widespread and intensive use has led to a significant challenge nowadays: the development of parasite resistance. This review focuses on the critical link between drug pharmacokinetics (variation in concentration profiles and exposure over time) and pharmacodynamics (drug efficacy) and the ability of both avermectin and milbemycin MLs families to control livestock ectoparasites. This review discusses the integrated assessment of drug behavior in the host, its diffusion into target parasites, and the impact of different pharmaceutical formulations on enhancing drug delivery to infection sites. These are considered critical research/development areas to optimize the use of MLs, preventing treatment failures and finally extending the lifespan of these essential pharmaceutical ingredients. Finally, the importance of the rational use of MLs, guided by parasite epidemiology and pharmacological knowledge, is emphasized as a key strategy to preserve the antiparasitic efficacy of these still very useful molecules.http://www.sciencedirect.com/science/article/pii/S221132072400040XMacrocyclic lactonesEctoparasite controlDrug resistance |
| spellingShingle | A. Lifschitz S. Nava V. Miró C. Canton L. Alvarez C. Lanusse Macrocyclic lactones and ectoparasites control in livestock: Efficacy, drug resistance and therapeutic challenges International Journal for Parasitology: Drugs and Drug Resistance Macrocyclic lactones Ectoparasite control Drug resistance |
| title | Macrocyclic lactones and ectoparasites control in livestock: Efficacy, drug resistance and therapeutic challenges |
| title_full | Macrocyclic lactones and ectoparasites control in livestock: Efficacy, drug resistance and therapeutic challenges |
| title_fullStr | Macrocyclic lactones and ectoparasites control in livestock: Efficacy, drug resistance and therapeutic challenges |
| title_full_unstemmed | Macrocyclic lactones and ectoparasites control in livestock: Efficacy, drug resistance and therapeutic challenges |
| title_short | Macrocyclic lactones and ectoparasites control in livestock: Efficacy, drug resistance and therapeutic challenges |
| title_sort | macrocyclic lactones and ectoparasites control in livestock efficacy drug resistance and therapeutic challenges |
| topic | Macrocyclic lactones Ectoparasite control Drug resistance |
| url | http://www.sciencedirect.com/science/article/pii/S221132072400040X |
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