Zopfiellamides C and D, New Decalin-Type Tetramic Acid Derivatives from the Marine-Derived Fungus <i>Aspergillus</i> sp. NF666
Two new decalin-tetramic acid hybrid metabolites, zopfiellamides C (<b>1</b>) and D (<b>2</b>) were isolated from the marine-derived fungus <i>Aspergillus</i> sp. NF666. The structure determination was accomplished on the basis of HRESIMS and NMR spectral data ana...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-03-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/30/7/1502 |
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| Summary: | Two new decalin-tetramic acid hybrid metabolites, zopfiellamides C (<b>1</b>) and D (<b>2</b>) were isolated from the marine-derived fungus <i>Aspergillus</i> sp. NF666. The structure determination was accomplished on the basis of HRESIMS and NMR spectral data analyses including COSY, HSQC, HMBC, and NOESY experiments. Both isolated metabolites (<b>1</b> and <b>2</b>) exhibited significant growth inhibition against four clinically relevant bacterial strains with minimum inhibitory concentration (MIC) values of about 12.5 μΜ. Moreover, we proposed a plausible biosynthetic pathway of zopfiellamide D (<b>2</b>) in this work. |
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| ISSN: | 1420-3049 |