The Effect of Salt-Processed Psoralea corylifolia on Generative Organ Targeting
Psoralen and isopsoralen are two isomers and main effective components within Psoralea corylifolia. In order to investigate the salt-processing effect on tissue distribution characters of psoralen and isopsoralen, a sensitive and accurate ultrahigh pressure liquid chromatographic tandem mass spectro...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Journal of Analytical Methods in Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2016/7484202 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849473053370613760 |
|---|---|
| author | Gen-hua Zhao Cui-ping Yan Zi-sheng Xu Qian-qian Gao Zhi-peng Chen Wei-dong Li |
| author_facet | Gen-hua Zhao Cui-ping Yan Zi-sheng Xu Qian-qian Gao Zhi-peng Chen Wei-dong Li |
| author_sort | Gen-hua Zhao |
| collection | DOAJ |
| description | Psoralen and isopsoralen are two isomers and main effective components within Psoralea corylifolia. In order to investigate the salt-processing effect on tissue distribution characters of psoralen and isopsoralen, a sensitive and accurate ultrahigh pressure liquid chromatographic tandem mass spectrometric (UHPLC-MS/MS) method has been developed and validated for simultaneous determination of the 2 components in rats’ tissues after administration of the extracts that came from either crude or salt-processed Psoralea corylifolia L. Data displayed that both areas under the curve (AUC) of psoralen and isopsoralen from salt-processed scurfpea fruit group were significantly increased compared with that of the crude herb group, especially in heart (p<0.05), ovary, and testes (p<0.001). Though the RE and RCmax of psoralen and isopsoralen in all of the investigated organs were over 1.0, generative organs kept the maximum value. The experiment manifested that salt-processing of scurfpea fruit can increase the distribution of psoralen and isopsoralen to generative organs, heart and spleen, and the distribution of psoralen and isopsoralen to generative organs is significantly higher compared to heart and spleen (p<0.01). Results indicate that salt-processing of scurfpea fruit can significantly increase the distribution of psoralen and isopsoralen to generative organs. |
| format | Article |
| id | doaj-art-db806f7b01b64b229d2b5be7bedb7be0 |
| institution | Kabale University |
| issn | 2090-8865 2090-8873 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Analytical Methods in Chemistry |
| spelling | doaj-art-db806f7b01b64b229d2b5be7bedb7be02025-08-20T03:24:20ZengWileyJournal of Analytical Methods in Chemistry2090-88652090-88732016-01-01201610.1155/2016/74842027484202The Effect of Salt-Processed Psoralea corylifolia on Generative Organ TargetingGen-hua Zhao0Cui-ping Yan1Zi-sheng Xu2Qian-qian Gao3Zhi-peng Chen4Wei-dong Li5College of Pharmacy, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Nanjing 210023, ChinaJiangsu Jumpcan Pharmaceutical Group Co., Ltd., Taizhou 225441, ChinaDepartment of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong KongCollege of Pharmacy, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Nanjing 210023, ChinaCollege of Pharmacy, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Nanjing 210023, ChinaCollege of Pharmacy, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Nanjing 210023, ChinaPsoralen and isopsoralen are two isomers and main effective components within Psoralea corylifolia. In order to investigate the salt-processing effect on tissue distribution characters of psoralen and isopsoralen, a sensitive and accurate ultrahigh pressure liquid chromatographic tandem mass spectrometric (UHPLC-MS/MS) method has been developed and validated for simultaneous determination of the 2 components in rats’ tissues after administration of the extracts that came from either crude or salt-processed Psoralea corylifolia L. Data displayed that both areas under the curve (AUC) of psoralen and isopsoralen from salt-processed scurfpea fruit group were significantly increased compared with that of the crude herb group, especially in heart (p<0.05), ovary, and testes (p<0.001). Though the RE and RCmax of psoralen and isopsoralen in all of the investigated organs were over 1.0, generative organs kept the maximum value. The experiment manifested that salt-processing of scurfpea fruit can increase the distribution of psoralen and isopsoralen to generative organs, heart and spleen, and the distribution of psoralen and isopsoralen to generative organs is significantly higher compared to heart and spleen (p<0.01). Results indicate that salt-processing of scurfpea fruit can significantly increase the distribution of psoralen and isopsoralen to generative organs.http://dx.doi.org/10.1155/2016/7484202 |
| spellingShingle | Gen-hua Zhao Cui-ping Yan Zi-sheng Xu Qian-qian Gao Zhi-peng Chen Wei-dong Li The Effect of Salt-Processed Psoralea corylifolia on Generative Organ Targeting Journal of Analytical Methods in Chemistry |
| title | The Effect of Salt-Processed Psoralea corylifolia on Generative Organ Targeting |
| title_full | The Effect of Salt-Processed Psoralea corylifolia on Generative Organ Targeting |
| title_fullStr | The Effect of Salt-Processed Psoralea corylifolia on Generative Organ Targeting |
| title_full_unstemmed | The Effect of Salt-Processed Psoralea corylifolia on Generative Organ Targeting |
| title_short | The Effect of Salt-Processed Psoralea corylifolia on Generative Organ Targeting |
| title_sort | effect of salt processed psoralea corylifolia on generative organ targeting |
| url | http://dx.doi.org/10.1155/2016/7484202 |
| work_keys_str_mv | AT genhuazhao theeffectofsaltprocessedpsoraleacorylifoliaongenerativeorgantargeting AT cuipingyan theeffectofsaltprocessedpsoraleacorylifoliaongenerativeorgantargeting AT zishengxu theeffectofsaltprocessedpsoraleacorylifoliaongenerativeorgantargeting AT qianqiangao theeffectofsaltprocessedpsoraleacorylifoliaongenerativeorgantargeting AT zhipengchen theeffectofsaltprocessedpsoraleacorylifoliaongenerativeorgantargeting AT weidongli theeffectofsaltprocessedpsoraleacorylifoliaongenerativeorgantargeting AT genhuazhao effectofsaltprocessedpsoraleacorylifoliaongenerativeorgantargeting AT cuipingyan effectofsaltprocessedpsoraleacorylifoliaongenerativeorgantargeting AT zishengxu effectofsaltprocessedpsoraleacorylifoliaongenerativeorgantargeting AT qianqiangao effectofsaltprocessedpsoraleacorylifoliaongenerativeorgantargeting AT zhipengchen effectofsaltprocessedpsoraleacorylifoliaongenerativeorgantargeting AT weidongli effectofsaltprocessedpsoraleacorylifoliaongenerativeorgantargeting |