Targeting mTOR Kinase with Natural Compounds: Potent ATP-Competitive Inhibition Through Enhanced Binding Mechanisms

Targeting mTOR Kinase with Natural Compounds: Potent ATP-Competitive Inhibition Through Enhanced Binding Mechanisms

<b>Background/Objectives</b>: The mammalian target of the rapamycin (mTOR) signaling pathway is a central regulator of cell growth, proliferation, metabolism, and survival. Dysregulation of mTOR signaling contributes to many human diseases, including cancer, diabetes, and obesity. Theref...

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Bibliographic Details
Main Authors: Sulaiman K. Marafie, Eman Alshawaf, Fahd Al-Mulla, Jehad Abubaker, Anwar Mohammad
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Pharmaceuticals
Subjects:
mTOR
kinase domain
ATP
mTOR inhibitors
natural compounds
molecular simulation
Online Access:https://www.mdpi.com/1424-8247/17/12/1677
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