Characterization of total DNA demethylation potential and its PBDE components of household airborne dust in three Chinese cities
Household dust is a major reservoir for indoor pollutants, yet its epigenetic effects remain poorly characterized. This study investigated household airborne dust’s total DNA demethylation potential (TDP) and its association with 14 priority polybrominated diphenyl ethers (PBDEs) in 43 residences ac...
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Elsevier
2025-09-01
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| Series: | Environment International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412025004842 |
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| author | Xiaotong Zhang Wenying Zhang Fengjing Song Tingting Liu Chengyu Chen Xiaomin Xie Chao Wang Hang Du Lin Fan Weiyi Zhang Yiming Sun Xianliang Wang |
| author_facet | Xiaotong Zhang Wenying Zhang Fengjing Song Tingting Liu Chengyu Chen Xiaomin Xie Chao Wang Hang Du Lin Fan Weiyi Zhang Yiming Sun Xianliang Wang |
| author_sort | Xiaotong Zhang |
| collection | DOAJ |
| description | Household dust is a major reservoir for indoor pollutants, yet its epigenetic effects remain poorly characterized. This study investigated household airborne dust’s total DNA demethylation potential (TDP) and its association with 14 priority polybrominated diphenyl ethers (PBDEs) in 43 residences across Lanzhou, Suzhou, and Harbin. The median TDP (5-AZA-CdR equivalent) was 0.016 (range: 0–1.006), while the median Σ14PBDEs concentration was 2085.73 ng/g (range: 64.51–26,746.47 ng/g), with BDE-209 dominating (>90 %). Exploratory factor analysis identified three principal components explaining 80.59 % of the variance, with PBDE levels significantly influenced by socioeconomic status, building materials, household products, and occupant behaviors (P < 0.05). Linear regression models revealed significant negative associations between TDP and BDE-153 (β = -0.020; 95 % CI: −0.035 to −0.005, β = -0.003; 95 % CI = −0.045 to −0.016), BDE-183 (β = -0.003; 95 % CI: −0.006 to −0.001), BDE-209 (β = -0.000; 95 % CI: −0.000 to −0.000), and Factor 2-derived congeners (β = -0.389; 95 % CI = -0.626 to −0.152, β = -0.389; 95 % CI = −0.616 to −0.162). In contrast, BDE-66 exhibited a positive association (β = 0.052; 95 % CI: 0.022 to 0.082). The findings suggest that household dust and its PBDE components may pose epigenetic health risks through DNA demethylation alterations. |
| format | Article |
| id | doaj-art-db4687e266f644c8b0b2e096ee3100f9 |
| institution | Kabale University |
| issn | 0160-4120 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj-art-db4687e266f644c8b0b2e096ee3100f92025-08-20T05:04:13ZengElsevierEnvironment International0160-41202025-09-0120310973310.1016/j.envint.2025.109733Characterization of total DNA demethylation potential and its PBDE components of household airborne dust in three Chinese citiesXiaotong Zhang0Wenying Zhang1Fengjing Song2Tingting Liu3Chengyu Chen4Xiaomin Xie5Chao Wang6Hang Du7Lin Fan8Weiyi Zhang9Yiming Sun10Xianliang Wang11China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China; School of Public Health, Nanjing Medical University, Nanjing, Jiangsu Province 210000, ChinaChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, ChinaChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China; School of Public Health, Nanjing Medical University, Nanjing, Jiangsu Province 210000, ChinaChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, ChinaChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, ChinaChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, ChinaChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, ChinaChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, ChinaChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, ChinaChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, ChinaChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, ChinaChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China; School of Public Health, Nanjing Medical University, Nanjing, Jiangsu Province 210000, China; Corresponding author at: National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, #7 Panjiayuan Nanli Road, Chaoyang District, Beijing 100021, PR China.Household dust is a major reservoir for indoor pollutants, yet its epigenetic effects remain poorly characterized. This study investigated household airborne dust’s total DNA demethylation potential (TDP) and its association with 14 priority polybrominated diphenyl ethers (PBDEs) in 43 residences across Lanzhou, Suzhou, and Harbin. The median TDP (5-AZA-CdR equivalent) was 0.016 (range: 0–1.006), while the median Σ14PBDEs concentration was 2085.73 ng/g (range: 64.51–26,746.47 ng/g), with BDE-209 dominating (>90 %). Exploratory factor analysis identified three principal components explaining 80.59 % of the variance, with PBDE levels significantly influenced by socioeconomic status, building materials, household products, and occupant behaviors (P < 0.05). Linear regression models revealed significant negative associations between TDP and BDE-153 (β = -0.020; 95 % CI: −0.035 to −0.005, β = -0.003; 95 % CI = −0.045 to −0.016), BDE-183 (β = -0.003; 95 % CI: −0.006 to −0.001), BDE-209 (β = -0.000; 95 % CI: −0.000 to −0.000), and Factor 2-derived congeners (β = -0.389; 95 % CI = -0.626 to −0.152, β = -0.389; 95 % CI = −0.616 to −0.162). In contrast, BDE-66 exhibited a positive association (β = 0.052; 95 % CI: 0.022 to 0.082). The findings suggest that household dust and its PBDE components may pose epigenetic health risks through DNA demethylation alterations.http://www.sciencedirect.com/science/article/pii/S0160412025004842Household dustTotal DNA demethylation potential (TDP)Polybrominated diphenyl ethers (PBDEs)Influential factors |
| spellingShingle | Xiaotong Zhang Wenying Zhang Fengjing Song Tingting Liu Chengyu Chen Xiaomin Xie Chao Wang Hang Du Lin Fan Weiyi Zhang Yiming Sun Xianliang Wang Characterization of total DNA demethylation potential and its PBDE components of household airborne dust in three Chinese cities Environment International Household dust Total DNA demethylation potential (TDP) Polybrominated diphenyl ethers (PBDEs) Influential factors |
| title | Characterization of total DNA demethylation potential and its PBDE components of household airborne dust in three Chinese cities |
| title_full | Characterization of total DNA demethylation potential and its PBDE components of household airborne dust in three Chinese cities |
| title_fullStr | Characterization of total DNA demethylation potential and its PBDE components of household airborne dust in three Chinese cities |
| title_full_unstemmed | Characterization of total DNA demethylation potential and its PBDE components of household airborne dust in three Chinese cities |
| title_short | Characterization of total DNA demethylation potential and its PBDE components of household airborne dust in three Chinese cities |
| title_sort | characterization of total dna demethylation potential and its pbde components of household airborne dust in three chinese cities |
| topic | Household dust Total DNA demethylation potential (TDP) Polybrominated diphenyl ethers (PBDEs) Influential factors |
| url | http://www.sciencedirect.com/science/article/pii/S0160412025004842 |
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