Fibroblasts activated by miRs-185-5p, miR-652-5p, and miR-1246 shape the tumor microenvironment in triple-negative breast cancer via PATZ1 downregulation

Fibroblasts activated by miRs-185-5p, miR-652-5p, and miR-1246 shape the tumor microenvironment in triple-negative breast cancer via PATZ1 downregulation

Abstract The intricate interplay between epithelial and fibroblast cells within the tumor microenvironment plays a crucial role in driving triple-negative breast cancer progression. This crosstalk involves the exchange of various signaling molecules, including growth factors, cytokines, extracellula...

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Main Authors: Giada De Luca, Gianluca Petrillo, Iolanda Scognamiglio, Katia Pane, Lorenza Cocca, Giuseppina Roscigno, Martina Mascolo, Claudia Pignataro, Sara Verde, Aurelia Fraticelli, Danilo Fiore, Alessandra Affinito, Silvia Nuzzo, Zoran Minic, Francesca De Micco, Guglielmo Thomas, Monica Franzese, Maxim V. Berezovski, Monica Fedele, Gerolama Condorelli, Cristina Quintavalle
Format: Article
Language:English
Published: Springer 2025-07-01
Series:Cellular and Molecular Life Sciences
Subjects:
Fibroblasts
CAFs
miRNAs
Extracellular vesicles
PATZ1
Online Access:https://doi.org/10.1007/s00018-025-05781-y
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