Different Current Intensities of Anodal Transcranial Direct Current Stimulation Do Not Differentially Modulate Motor Cortex Plasticity
Transcranial direct current stimulation (tDCS) is a noninvasive technique that modulates the excitability of neurons within the motor cortex (M1). Although the aftereffects of anodal tDCS on modulating cortical excitability have been described, there is limited data describing the outcomes of differ...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2013/603502 |
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| author | Dawson J. Kidgell Robin M. Daly Kayleigh Young Jarrod Lum Gregory Tooley Shapour Jaberzadeh Maryam Zoghi Alan J. Pearce |
| author_facet | Dawson J. Kidgell Robin M. Daly Kayleigh Young Jarrod Lum Gregory Tooley Shapour Jaberzadeh Maryam Zoghi Alan J. Pearce |
| author_sort | Dawson J. Kidgell |
| collection | DOAJ |
| description | Transcranial direct current stimulation (tDCS) is a noninvasive technique that modulates the excitability of neurons within the motor cortex (M1). Although the aftereffects of anodal tDCS on modulating cortical excitability have been described, there is limited data describing the outcomes of different tDCS intensities on intracortical circuits. To further elucidate the mechanisms underlying the aftereffects of M1 excitability following anodal tDCS, we used transcranial magnetic stimulation (TMS) to examine the effect of different intensities on cortical excitability and short-interval intracortical inhibition (SICI). Using a randomized, counterbalanced, crossover design, with a one-week wash-out period, 14 participants (6 females and 8 males, 22–45 years) were exposed to 10 minutes of anodal tDCS at 0.8, 1.0, and 1.2 mA. TMS was used to measure M1 excitability and SICI of the contralateral wrist extensor muscle at baseline, immediately after and 15 and 30 minutes following cessation of anodal tDCS. Cortical excitability increased, whilst SICI was reduced at all time points following anodal tDCS. Interestingly, there were no differences between the three intensities of anodal tDCS on modulating cortical excitability or SICI. These results suggest that the aftereffect of anodal tDCS on facilitating cortical excitability is due to the modulation of synaptic mechanisms associated with long-term potentiation and is not influenced by different tDCS intensities. |
| format | Article |
| id | doaj-art-db4099cf9071439aac74bbe209beea38 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-db4099cf9071439aac74bbe209beea382025-02-03T05:53:19ZengWileyNeural Plasticity2090-59041687-54432013-01-01201310.1155/2013/603502603502Different Current Intensities of Anodal Transcranial Direct Current Stimulation Do Not Differentially Modulate Motor Cortex PlasticityDawson J. Kidgell0Robin M. Daly1Kayleigh Young2Jarrod Lum3Gregory Tooley4Shapour Jaberzadeh5Maryam Zoghi6Alan J. Pearce7Centre for Physical Activity and Nutrition Research, School of Exercise and Nutrition Sciences, Deakin University, Melbourne, VIC 3125, AustraliaCentre for Physical Activity and Nutrition Research, School of Exercise and Nutrition Sciences, Deakin University, Melbourne, VIC 3125, AustraliaCentre for Physical Activity and Nutrition Research, School of Exercise and Nutrition Sciences, Deakin University, Melbourne, VIC 3125, AustraliaCognitive and Exercise Neuroscience Unit, School of Psychology, Deakin University, Melbourne, VIC 3125, AustraliaCognitive and Exercise Neuroscience Unit, School of Psychology, Deakin University, Melbourne, VIC 3125, AustraliaSchool of Physiotherapy, Monash University, Melbourne, VIC 3199, AustraliaCentre for Physical Activity and Nutrition Research, School of Exercise and Nutrition Sciences, Deakin University, Melbourne, VIC 3125, AustraliaCognitive and Exercise Neuroscience Unit, School of Psychology, Deakin University, Melbourne, VIC 3125, AustraliaTranscranial direct current stimulation (tDCS) is a noninvasive technique that modulates the excitability of neurons within the motor cortex (M1). Although the aftereffects of anodal tDCS on modulating cortical excitability have been described, there is limited data describing the outcomes of different tDCS intensities on intracortical circuits. To further elucidate the mechanisms underlying the aftereffects of M1 excitability following anodal tDCS, we used transcranial magnetic stimulation (TMS) to examine the effect of different intensities on cortical excitability and short-interval intracortical inhibition (SICI). Using a randomized, counterbalanced, crossover design, with a one-week wash-out period, 14 participants (6 females and 8 males, 22–45 years) were exposed to 10 minutes of anodal tDCS at 0.8, 1.0, and 1.2 mA. TMS was used to measure M1 excitability and SICI of the contralateral wrist extensor muscle at baseline, immediately after and 15 and 30 minutes following cessation of anodal tDCS. Cortical excitability increased, whilst SICI was reduced at all time points following anodal tDCS. Interestingly, there were no differences between the three intensities of anodal tDCS on modulating cortical excitability or SICI. These results suggest that the aftereffect of anodal tDCS on facilitating cortical excitability is due to the modulation of synaptic mechanisms associated with long-term potentiation and is not influenced by different tDCS intensities.http://dx.doi.org/10.1155/2013/603502 |
| spellingShingle | Dawson J. Kidgell Robin M. Daly Kayleigh Young Jarrod Lum Gregory Tooley Shapour Jaberzadeh Maryam Zoghi Alan J. Pearce Different Current Intensities of Anodal Transcranial Direct Current Stimulation Do Not Differentially Modulate Motor Cortex Plasticity Neural Plasticity |
| title | Different Current Intensities of Anodal Transcranial Direct Current Stimulation Do Not Differentially Modulate Motor Cortex Plasticity |
| title_full | Different Current Intensities of Anodal Transcranial Direct Current Stimulation Do Not Differentially Modulate Motor Cortex Plasticity |
| title_fullStr | Different Current Intensities of Anodal Transcranial Direct Current Stimulation Do Not Differentially Modulate Motor Cortex Plasticity |
| title_full_unstemmed | Different Current Intensities of Anodal Transcranial Direct Current Stimulation Do Not Differentially Modulate Motor Cortex Plasticity |
| title_short | Different Current Intensities of Anodal Transcranial Direct Current Stimulation Do Not Differentially Modulate Motor Cortex Plasticity |
| title_sort | different current intensities of anodal transcranial direct current stimulation do not differentially modulate motor cortex plasticity |
| url | http://dx.doi.org/10.1155/2013/603502 |
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