Comparative evaluation of serum apelin, visfatin, and lipid levels in overweight hypertensive patients on enalapril versus telmisartan therapy
Objectives. Visfatin and apelin are two adipokines that recently gained a special interest in hypertension research as they may have a role in the pathogenesis of hypertension and are closely related to the renin-angiotensin system. This study aimed to evaluate the serum levels of apelin and visfati...
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Amaltea Medical Publishing House
2024-09-01
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| Series: | Romanian Journal of Medical Practice |
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| Online Access: | https://rjmp.com.ro/articles/2024.3/RJMP_2024_3_Art-02.pdf |
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| author | Mina Khalid MOHAMMED Ahmed Moyed HUSSEIN Jehan Abdulwahab MOHAMMAD Zainab Haitham FATHI |
| author_facet | Mina Khalid MOHAMMED Ahmed Moyed HUSSEIN Jehan Abdulwahab MOHAMMAD Zainab Haitham FATHI |
| author_sort | Mina Khalid MOHAMMED |
| collection | DOAJ |
| description | Objectives. Visfatin and apelin are two adipokines that recently gained a special interest in hypertension research as they may have a role in the pathogenesis of hypertension and are closely related to the renin-angiotensin system. This study aimed to evaluate the serum levels of apelin and visfatin in uncontrolled newly
diagnosed hypertensive patients, controlled hypertensive patients managed by enalapril and controlled hypertensive patients managed by telmisartan. Patients and methods. The study population included 126 participants, who were divided into four groups established as healthy participants, newly diagnosed hypertensive patients, hypertensive patients managed by enalapril and hypertensive patients managed by telmisartan. Outcomes. Serum apelin levels reduced significantly in newly diagnosed hypertensive patients, with a
significant increase in visfatin levels compared with control group. Enalapril-treated patients expressed significantly higher apelin levels with a significant reduction in visfatin levels compared with newly diagnosed. Apelin levels were significantly increased in enalapril-treated patients compared telmisartan-treated group. Additionally, a significant reduction in visfatin levels were found in telmisartan group compared with newly diagnosed hypertensive patients. Moreover, a significant positive correlation was found between HDL and visfatin in patients receiving treatment. Additionally, visfatin was negatively correlated with triglycerides and VLDL in the same patient group. Conclusions. In light of the data collected so far, whether visfatin and apelin play roles in the pathophysiology of hypertension remains unclear and further research is still required to fully understand its relevance. Nevertheless, high visfatin and low apelin levels appear to be intrinsic characteristics of uncontrolled hypertension, indicating that these adipokines could be potential biomarkers for this disease. |
| format | Article |
| id | doaj-art-db2da4caa30e4d28b1dc14cc8e7bc52d |
| institution | Kabale University |
| issn | 1842-8258 2069-6108 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Amaltea Medical Publishing House |
| record_format | Article |
| series | Romanian Journal of Medical Practice |
| spelling | doaj-art-db2da4caa30e4d28b1dc14cc8e7bc52d2024-12-18T14:18:44ZengAmaltea Medical Publishing HouseRomanian Journal of Medical Practice1842-82582069-61082024-09-0119324124710.37897/RJMP.2024.3.2Comparative evaluation of serum apelin, visfatin, and lipid levels in overweight hypertensive patients on enalapril versus telmisartan therapyMina Khalid MOHAMMED0https://orcid.org/0009-0002-2403-753XAhmed Moyed HUSSEIN1Jehan Abdulwahab MOHAMMAD2https://orcid.org/0000-0001-6831-7619Zainab Haitham FATHI3https://orcid.org/0000-0003-0327-0914Department of Pharmacognosy and Medicinal Plants, College of Pharmacy, University of Mosul, Mosul, IraqDepartment of Medicine, University of Ninevah, College of Medicine, Mosul, IraqDepartment of Pharmacognosy and Medicinal Plants, College of Pharmacy, University of Mosul, Mosul, IraqDepartment of Pharmacognosy and Medicinal Plants, College of Pharmacy, University of Mosul, Mosul, IraqObjectives. Visfatin and apelin are two adipokines that recently gained a special interest in hypertension research as they may have a role in the pathogenesis of hypertension and are closely related to the renin-angiotensin system. This study aimed to evaluate the serum levels of apelin and visfatin in uncontrolled newly diagnosed hypertensive patients, controlled hypertensive patients managed by enalapril and controlled hypertensive patients managed by telmisartan. Patients and methods. The study population included 126 participants, who were divided into four groups established as healthy participants, newly diagnosed hypertensive patients, hypertensive patients managed by enalapril and hypertensive patients managed by telmisartan. Outcomes. Serum apelin levels reduced significantly in newly diagnosed hypertensive patients, with a significant increase in visfatin levels compared with control group. Enalapril-treated patients expressed significantly higher apelin levels with a significant reduction in visfatin levels compared with newly diagnosed. Apelin levels were significantly increased in enalapril-treated patients compared telmisartan-treated group. Additionally, a significant reduction in visfatin levels were found in telmisartan group compared with newly diagnosed hypertensive patients. Moreover, a significant positive correlation was found between HDL and visfatin in patients receiving treatment. Additionally, visfatin was negatively correlated with triglycerides and VLDL in the same patient group. Conclusions. In light of the data collected so far, whether visfatin and apelin play roles in the pathophysiology of hypertension remains unclear and further research is still required to fully understand its relevance. Nevertheless, high visfatin and low apelin levels appear to be intrinsic characteristics of uncontrolled hypertension, indicating that these adipokines could be potential biomarkers for this disease.https://rjmp.com.ro/articles/2024.3/RJMP_2024_3_Art-02.pdfapelinhypertensionvisfatintelmisartanenalapril |
| spellingShingle | Mina Khalid MOHAMMED Ahmed Moyed HUSSEIN Jehan Abdulwahab MOHAMMAD Zainab Haitham FATHI Comparative evaluation of serum apelin, visfatin, and lipid levels in overweight hypertensive patients on enalapril versus telmisartan therapy Romanian Journal of Medical Practice apelin hypertension visfatin telmisartan enalapril |
| title | Comparative evaluation of serum apelin, visfatin, and lipid levels in overweight hypertensive patients on enalapril versus telmisartan therapy |
| title_full | Comparative evaluation of serum apelin, visfatin, and lipid levels in overweight hypertensive patients on enalapril versus telmisartan therapy |
| title_fullStr | Comparative evaluation of serum apelin, visfatin, and lipid levels in overweight hypertensive patients on enalapril versus telmisartan therapy |
| title_full_unstemmed | Comparative evaluation of serum apelin, visfatin, and lipid levels in overweight hypertensive patients on enalapril versus telmisartan therapy |
| title_short | Comparative evaluation of serum apelin, visfatin, and lipid levels in overweight hypertensive patients on enalapril versus telmisartan therapy |
| title_sort | comparative evaluation of serum apelin visfatin and lipid levels in overweight hypertensive patients on enalapril versus telmisartan therapy |
| topic | apelin hypertension visfatin telmisartan enalapril |
| url | https://rjmp.com.ro/articles/2024.3/RJMP_2024_3_Art-02.pdf |
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