Investigation of transport properties of hydroxyapatite and its silicon-substituted derivatives
The article discusses the possibility of practical application of hydroxyapatite and silicon-substituted hydroxyapatite as components of medicines, pharmaceutical compositions, and biomaterials, the use of which is based on the transdermal delivery route of the active substance. The specific surface...
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| Format: | Article |
| Language: | Russian |
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Tver State University
2024-12-01
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| Series: | Физико-химические аспекты изучения кластеров, наноструктур и наноматериалов |
| Subjects: | |
| Online Access: | https://physchemaspects.ru/2024/doi-10-26456-pcascnn-2024-16-767/?lang=en |
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| _version_ | 1846100486575357952 |
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| author | E.A. Bogdanova T.G. Khonina N.A. Sabirzyanov |
| author_facet | E.A. Bogdanova T.G. Khonina N.A. Sabirzyanov |
| author_sort | E.A. Bogdanova |
| collection | DOAJ |
| description | The article discusses the possibility of practical application of hydroxyapatite and silicon-substituted hydroxyapatite as components of medicines, pharmaceutical compositions, and biomaterials, the use of which is based on the transdermal delivery route of the active substance. The specific surface area, degree of dispersion and transport properties (transmucose permeability) of hydroxyapatite and silicon-substituted hydroxyapatite were estimated using some modern physicochemical methods of analysis. Particular attention is paid to the joint use of the studied substances and silicon glycerolates as a conductor with pronounced transcutaneous, penetrating properties, contributing to the accumulation of locally applied drugs in biological membranes (skin, mucosa, etc.) without disturbing its structure. It is shown that the transport properties that determine the effectiveness of the action depend on physico-chemical characteristics of these substances being penetrated. Diffusion transfer and the ability to control the processes taking place can be used for optimal design of drugs for targeted delivery through the skin and mucous membranes. |
| format | Article |
| id | doaj-art-db2a5b35a62e4e90bfa9b31ab8462345 |
| institution | Kabale University |
| issn | 2226-4442 2658-4360 |
| language | Russian |
| publishDate | 2024-12-01 |
| publisher | Tver State University |
| record_format | Article |
| series | Физико-химические аспекты изучения кластеров, наноструктур и наноматериалов |
| spelling | doaj-art-db2a5b35a62e4e90bfa9b31ab84623452024-12-30T08:17:00ZrusTver State UniversityФизико-химические аспекты изучения кластеров, наноструктур и наноматериалов2226-44422658-43602024-12-011676777810.26456/pcascnn/2024.16.767Investigation of transport properties of hydroxyapatite and its silicon-substituted derivativesE.A. Bogdanova0T.G. Khonina1N.A. Sabirzyanov2Institute of Solid State Chemistry of the Ural Branch of RAS, JSC GiredmetI.Ya. Postovsky Institute of Organic Synthesis Ural Branch of RASInstitute of Solid State Chemistry of the Ural Branch of RASThe article discusses the possibility of practical application of hydroxyapatite and silicon-substituted hydroxyapatite as components of medicines, pharmaceutical compositions, and biomaterials, the use of which is based on the transdermal delivery route of the active substance. The specific surface area, degree of dispersion and transport properties (transmucose permeability) of hydroxyapatite and silicon-substituted hydroxyapatite were estimated using some modern physicochemical methods of analysis. Particular attention is paid to the joint use of the studied substances and silicon glycerolates as a conductor with pronounced transcutaneous, penetrating properties, contributing to the accumulation of locally applied drugs in biological membranes (skin, mucosa, etc.) without disturbing its structure. It is shown that the transport properties that determine the effectiveness of the action depend on physico-chemical characteristics of these substances being penetrated. Diffusion transfer and the ability to control the processes taking place can be used for optimal design of drugs for targeted delivery through the skin and mucous membranes. https://physchemaspects.ru/2024/doi-10-26456-pcascnn-2024-16-767/?lang=enhydroxyapatitesiliconsubstituted hydroxyapatitesiliconglycerolatastransmucosal permeability |
| spellingShingle | E.A. Bogdanova T.G. Khonina N.A. Sabirzyanov Investigation of transport properties of hydroxyapatite and its silicon-substituted derivatives Физико-химические аспекты изучения кластеров, наноструктур и наноматериалов hydroxyapatite siliconsubstituted hydroxyapatite siliconglycerolatas transmucosal permeability |
| title | Investigation of transport properties of hydroxyapatite and its silicon-substituted derivatives |
| title_full | Investigation of transport properties of hydroxyapatite and its silicon-substituted derivatives |
| title_fullStr | Investigation of transport properties of hydroxyapatite and its silicon-substituted derivatives |
| title_full_unstemmed | Investigation of transport properties of hydroxyapatite and its silicon-substituted derivatives |
| title_short | Investigation of transport properties of hydroxyapatite and its silicon-substituted derivatives |
| title_sort | investigation of transport properties of hydroxyapatite and its silicon substituted derivatives |
| topic | hydroxyapatite siliconsubstituted hydroxyapatite siliconglycerolatas transmucosal permeability |
| url | https://physchemaspects.ru/2024/doi-10-26456-pcascnn-2024-16-767/?lang=en |
| work_keys_str_mv | AT eabogdanova investigationoftransportpropertiesofhydroxyapatiteanditssiliconsubstitutedderivatives AT tgkhonina investigationoftransportpropertiesofhydroxyapatiteanditssiliconsubstitutedderivatives AT nasabirzyanov investigationoftransportpropertiesofhydroxyapatiteanditssiliconsubstitutedderivatives |