The Efficacy of Madeira Vine Leaf Extract Combined with Turmeric Rhizome Extract Gel Topically on Second-Degree Burn Wound in Albino Rats
Burns is now considered one of the most destructive forms of trauma affecting humans and animals. This study aimed to determine the effect of Madeira vine leaf extract combined with 2% Turmeric rhizome extract (MVLTR) gel administered topically on second-degree burn wound in albino rats based on the...
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Universitas Airlangga, Faculty of Veterinary Medicine
2023-12-01
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| Series: | Jurnal Medik Veteriner |
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| Online Access: | https://e-journal.unair.ac.id/JMV/article/view/46243 |
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| author | Mirza Atikah Madarina Hisyam Wiwik Misaco Yuniarti Sis Wisnuarti Theresia Ira Sari Yudaniayanti Bambang Sektiari Lukiswanto Sri Agus Sudjarwo Thomas Valentinus Widiyatno |
| author_facet | Mirza Atikah Madarina Hisyam Wiwik Misaco Yuniarti Sis Wisnuarti Theresia Ira Sari Yudaniayanti Bambang Sektiari Lukiswanto Sri Agus Sudjarwo Thomas Valentinus Widiyatno |
| author_sort | Mirza Atikah Madarina Hisyam |
| collection | DOAJ |
| description | Burns is now considered one of the most destructive forms of trauma affecting humans and animals. This study aimed to determine the effect of Madeira vine leaf extract combined with 2% Turmeric rhizome extract (MVLTR) gel administered topically on second-degree burn wound in albino rats based on the number of fibroblasts. A total of 25 male rats weighed 200–300 grams were divided into five groups i.e. (C-) was normal skin, (C+) was burn and treated using 1% silver sulfadiazine, (T1) was burn and treated using 1.25% MVLTR gel, (T2) was burn and treated using 2.5% MVLTR gel, and (T3) was burn and treated using 5% MVLTR gel. The burn wound was performed on the right gluteus of rats, and the therapy was applied twice a day topically, starting after the burn wounds were made. Skin samples were collected on day 15. The histopathological examination was performed by counting fibroblast cells and then analyzed using One-way ANOVA, continued with the Duncan test. Based on the results showed that the C- group was significantly different compared to C+, T1, T2, and T3 groups. C+ had a significant difference with the T1 and T3 groups, meanwhile not significantly different from the T2 group. T2 was not significantly different from the C+ and T3 groups. In conclusion, MVLTR gel at 5% concentration has the potential to be an effective treatment for second-degree burns, as indicated by the increased number of fibroblasts. |
| format | Article |
| id | doaj-art-db257e6148f642a09aa127c91d9d547c |
| institution | Kabale University |
| issn | 2615-7497 2581-012X |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Universitas Airlangga, Faculty of Veterinary Medicine |
| record_format | Article |
| series | Jurnal Medik Veteriner |
| spelling | doaj-art-db257e6148f642a09aa127c91d9d547c2025-01-03T00:12:40ZengUniversitas Airlangga, Faculty of Veterinary MedicineJurnal Medik Veteriner2615-74972581-012X2023-12-0163919810.20473/jmv.vol6.iss3.2023.91-9844329The Efficacy of Madeira Vine Leaf Extract Combined with Turmeric Rhizome Extract Gel Topically on Second-Degree Burn Wound in Albino RatsMirza Atikah Madarina Hisyam0https://orcid.org/0009-0000-2939-1082Wiwik Misaco Yuniarti1https://orcid.org/0000-0002-6160-2983Sis Wisnuarti Theresia2https://orcid.org/0009-0000-2939-1082Ira Sari Yudaniayanti3https://orcid.org/0000-0003-2994-3208Bambang Sektiari Lukiswanto4https://orcid.org/0000-0002-3766-4199Sri Agus Sudjarwo5https://orcid.org/0000-0002-5184-2377Thomas Valentinus Widiyatno6https://orcid.org/0000-0002-0745-3796Department of Veterinary Clinic, Faculty of Veterinary Medicine, Universitas Airlangga, SurabayaDepartment of Veterinary Clinic, Faculty of Veterinary Medicine, Universitas Airlangga, SurabayaBachelor Program of Veterinary Medicine, Faculty of Veterinary Medicine, Universitas Airlangga, SurabayaDepartment of Veterinary Clinic, Faculty of Veterinary Medicine, Universitas Airlangga, SurabayaDepartment of Veterinary Clinic, Faculty of Veterinary Medicine, Universitas Airlangga, SurabayaDepartment of Basic Veterinary Medicine, Faculty of Veterinary Medicine, Universitas Airlangga, SurabayaDepartment of Veterinary Pathology, Faculty of Veterinary Medicine, Universitas Airlangga, SurabayaBurns is now considered one of the most destructive forms of trauma affecting humans and animals. This study aimed to determine the effect of Madeira vine leaf extract combined with 2% Turmeric rhizome extract (MVLTR) gel administered topically on second-degree burn wound in albino rats based on the number of fibroblasts. A total of 25 male rats weighed 200–300 grams were divided into five groups i.e. (C-) was normal skin, (C+) was burn and treated using 1% silver sulfadiazine, (T1) was burn and treated using 1.25% MVLTR gel, (T2) was burn and treated using 2.5% MVLTR gel, and (T3) was burn and treated using 5% MVLTR gel. The burn wound was performed on the right gluteus of rats, and the therapy was applied twice a day topically, starting after the burn wounds were made. Skin samples were collected on day 15. The histopathological examination was performed by counting fibroblast cells and then analyzed using One-way ANOVA, continued with the Duncan test. Based on the results showed that the C- group was significantly different compared to C+, T1, T2, and T3 groups. C+ had a significant difference with the T1 and T3 groups, meanwhile not significantly different from the T2 group. T2 was not significantly different from the C+ and T3 groups. In conclusion, MVLTR gel at 5% concentration has the potential to be an effective treatment for second-degree burns, as indicated by the increased number of fibroblasts.https://e-journal.unair.ac.id/JMV/article/view/46243burn woundhealthmadeira vine leafturmeric rhizome |
| spellingShingle | Mirza Atikah Madarina Hisyam Wiwik Misaco Yuniarti Sis Wisnuarti Theresia Ira Sari Yudaniayanti Bambang Sektiari Lukiswanto Sri Agus Sudjarwo Thomas Valentinus Widiyatno The Efficacy of Madeira Vine Leaf Extract Combined with Turmeric Rhizome Extract Gel Topically on Second-Degree Burn Wound in Albino Rats Jurnal Medik Veteriner burn wound health madeira vine leaf turmeric rhizome |
| title | The Efficacy of Madeira Vine Leaf Extract Combined with Turmeric Rhizome Extract Gel Topically on Second-Degree Burn Wound in Albino Rats |
| title_full | The Efficacy of Madeira Vine Leaf Extract Combined with Turmeric Rhizome Extract Gel Topically on Second-Degree Burn Wound in Albino Rats |
| title_fullStr | The Efficacy of Madeira Vine Leaf Extract Combined with Turmeric Rhizome Extract Gel Topically on Second-Degree Burn Wound in Albino Rats |
| title_full_unstemmed | The Efficacy of Madeira Vine Leaf Extract Combined with Turmeric Rhizome Extract Gel Topically on Second-Degree Burn Wound in Albino Rats |
| title_short | The Efficacy of Madeira Vine Leaf Extract Combined with Turmeric Rhizome Extract Gel Topically on Second-Degree Burn Wound in Albino Rats |
| title_sort | efficacy of madeira vine leaf extract combined with turmeric rhizome extract gel topically on second degree burn wound in albino rats |
| topic | burn wound health madeira vine leaf turmeric rhizome |
| url | https://e-journal.unair.ac.id/JMV/article/view/46243 |
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