Fermented Ofada rice (A Nigerian recipe) attenuates renal and hepatic dysfunction induced by crude oil poisoning in Wistar Rats
Objectives: This work examined the antioxidative capacity of Ofada rice Koji (ORK) to ameliorate toxicity emanating from Bonny Light Crude Oil (BLCO) on xenobiotic targeted tissues (liver and kidney) in rats. Methods: Twenty Wistar rats were divided into 4groups (ABCD). Short-term crude oil toxic...
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Babcock Medical Society
2024-12-01
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| Series: | Babcock University Medical Journal |
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| Online Access: | http://bumj.babcock.edu.ng/index.php/bumj/article/view/358 |
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| author | E Aganbi B. O. Odeghe ORORORO OSUVWE E. T. Ojugbeli J. C. Mordi |
| author_facet | E Aganbi B. O. Odeghe ORORORO OSUVWE E. T. Ojugbeli J. C. Mordi |
| author_sort | E Aganbi |
| collection | DOAJ |
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Objectives: This work examined the antioxidative capacity of Ofada rice Koji (ORK) to ameliorate toxicity emanating from Bonny Light Crude Oil (BLCO) on xenobiotic targeted tissues (liver and kidney) in rats.
Methods: Twenty Wistar rats were divided into 4groups (ABCD). Short-term crude oil toxicity was conducted for seven days. Groups A (positive control) were exempted and devoid of the toxicant while B (negative control) to D were administered 4ml BLCO/kg bwt. Group C was fed with 40g of standard rat feed mixed with 60g of fermented ORK powder (60% w/w) while group D animals were given 95g of standard rat feed mixed with 5g of ascorbic acid (ASC) (5g w/w) by composition. ORK and ASC diets were given for 14 days.
Results: ORK intake reduced Malondialdehyde (MDA) formation in the kidney and liver by 46% and 61% respectively. Assessment of Catalase (CAT), Superoxide dismutase (SOD), and Glutathione (GSH), when compared with untreated control rats, were increased by 28%, 45% and 24% respectively (for kidney) and 19%, 34% and 38% respectively (for liver). ORK maintained these enzyme levels by 17%, 4% and 14% respectively (for kidney) and 7%, 14% and 17% respectively (for liver). Renal creatinine and urea were elevated by BLCO treatment but were normalized by ORK intake. The severe alteration in renal and hepatic morphology as observed with BLCO intubation was almost regularized by ORK intake.
Conclusion: Data from this experimental research expresses the ameliorative capacity of ORK in BLCO toxicity.
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| format | Article |
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| institution | Kabale University |
| issn | 2465-6666 2756-4657 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Babcock Medical Society |
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| series | Babcock University Medical Journal |
| spelling | doaj-art-db1f88eba1d541788fe1590ccc524c6f2025-01-05T18:31:41ZengBabcock Medical SocietyBabcock University Medical Journal2465-66662756-46572024-12-017210.38029/babcockuniv.med.j..v7i2.358Fermented Ofada rice (A Nigerian recipe) attenuates renal and hepatic dysfunction induced by crude oil poisoning in Wistar RatsE Aganbi0B. O. Odeghe1ORORORO OSUVWE2E. T. Ojugbeli3J. C. Mordi4Department of Biochemistry, Faculty of Sciences, Delta State University Abraka, Delta State, NigeriaDepartment of Medical Biochemistry, Faculty of Basic Medical Sciences, Delta State University Abraka, Delta State, NigeriaDepartment of Medical Biochemistry, Faculty of Basic Medical Sciences, Delta State University Abraka, Delta State, NigeriaDepartment of Biochemistry, Faculty of Sciences, Delta State University Abraka, Delta State, NigeriaDepartment of Medical Biochemistry, Faculty of Basic Medical Sciences, Delta State University Abraka, Delta State, Nigeria Objectives: This work examined the antioxidative capacity of Ofada rice Koji (ORK) to ameliorate toxicity emanating from Bonny Light Crude Oil (BLCO) on xenobiotic targeted tissues (liver and kidney) in rats. Methods: Twenty Wistar rats were divided into 4groups (ABCD). Short-term crude oil toxicity was conducted for seven days. Groups A (positive control) were exempted and devoid of the toxicant while B (negative control) to D were administered 4ml BLCO/kg bwt. Group C was fed with 40g of standard rat feed mixed with 60g of fermented ORK powder (60% w/w) while group D animals were given 95g of standard rat feed mixed with 5g of ascorbic acid (ASC) (5g w/w) by composition. ORK and ASC diets were given for 14 days. Results: ORK intake reduced Malondialdehyde (MDA) formation in the kidney and liver by 46% and 61% respectively. Assessment of Catalase (CAT), Superoxide dismutase (SOD), and Glutathione (GSH), when compared with untreated control rats, were increased by 28%, 45% and 24% respectively (for kidney) and 19%, 34% and 38% respectively (for liver). ORK maintained these enzyme levels by 17%, 4% and 14% respectively (for kidney) and 7%, 14% and 17% respectively (for liver). Renal creatinine and urea were elevated by BLCO treatment but were normalized by ORK intake. The severe alteration in renal and hepatic morphology as observed with BLCO intubation was almost regularized by ORK intake. Conclusion: Data from this experimental research expresses the ameliorative capacity of ORK in BLCO toxicity. http://bumj.babcock.edu.ng/index.php/bumj/article/view/358Bonny Light Crude Oil (BLCO)Ofada rice Koji (ORK)Ascorbic acid (ASC)Antioxidant activityOxidative stress |
| spellingShingle | E Aganbi B. O. Odeghe ORORORO OSUVWE E. T. Ojugbeli J. C. Mordi Fermented Ofada rice (A Nigerian recipe) attenuates renal and hepatic dysfunction induced by crude oil poisoning in Wistar Rats Babcock University Medical Journal Bonny Light Crude Oil (BLCO) Ofada rice Koji (ORK) Ascorbic acid (ASC) Antioxidant activity Oxidative stress |
| title | Fermented Ofada rice (A Nigerian recipe) attenuates renal and hepatic dysfunction induced by crude oil poisoning in Wistar Rats |
| title_full | Fermented Ofada rice (A Nigerian recipe) attenuates renal and hepatic dysfunction induced by crude oil poisoning in Wistar Rats |
| title_fullStr | Fermented Ofada rice (A Nigerian recipe) attenuates renal and hepatic dysfunction induced by crude oil poisoning in Wistar Rats |
| title_full_unstemmed | Fermented Ofada rice (A Nigerian recipe) attenuates renal and hepatic dysfunction induced by crude oil poisoning in Wistar Rats |
| title_short | Fermented Ofada rice (A Nigerian recipe) attenuates renal and hepatic dysfunction induced by crude oil poisoning in Wistar Rats |
| title_sort | fermented ofada rice a nigerian recipe attenuates renal and hepatic dysfunction induced by crude oil poisoning in wistar rats |
| topic | Bonny Light Crude Oil (BLCO) Ofada rice Koji (ORK) Ascorbic acid (ASC) Antioxidant activity Oxidative stress |
| url | http://bumj.babcock.edu.ng/index.php/bumj/article/view/358 |
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