The relationship between IDH, P53 mutations, MGMT methylation with characteristics in high grade glioma patients
Introduction: Some gene mutations in high grade glioma patients have many implications in prognosis and treatment response. Objectives: To describe the characteristics and associations of IDH, TP53 gene mutations and MGMT methylation status with some characteristics and treatment response in patient...
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| Format: | Article |
| Language: | Spanish |
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ECIMED
2022-07-01
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| Series: | Revista Cubana de Medicina Militar |
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| Online Access: | https://revmedmilitar.sld.cu/index.php/mil/article/view/2004 |
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| _version_ | 1841546391116054528 |
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| author | Duc Anh Tran Ba Van Nguyen Bac Thanh Nguyen Hoe Van Vu Lien Duc Nguyen |
| author_facet | Duc Anh Tran Ba Van Nguyen Bac Thanh Nguyen Hoe Van Vu Lien Duc Nguyen |
| author_sort | Duc Anh Tran |
| collection | DOAJ |
| description | Introduction: Some gene mutations in high grade glioma patients have many implications in prognosis and treatment response.
Objectives: To describe the characteristics and associations of IDH, TP53 gene mutations and MGMT methylation status with some characteristics and treatment response in patients with high grade glioma.
Methods: A descriptive, prospective, uncontrolled study was conducted, in 52 patients with high-grade glioma. Research variables include age, sex, Karnofsky score, the rate of IDH, P53 mutation, MGMT methylation; the relationship between genes mutation with some characteristics and response to treatment according to the RECIST classification.
Results: For IDH gene mutation, grade III patients (23.1%) have a higher positive rate than grade IV (11.5 %); for P53 gene mutation, grade III patients (55.6 %) have a higher positive rate than grade IV (44.1 %); the rate of MGMT promoter methylation occurred in the study group of patients with the rate of 42.3 %. There is a relationship between IDH gene mutation with pathological results and malignancy in studied patients. Patients with the mutant expression of the IDH gene, p53, MGMT methylation status had better RECIST responses than patients without these expressions.
Conclusion: High-grade glioma mainly occurs in men, over 40 years old. The presence of mutations in IDH, P53 genes, and MGMT methylation status was a beneficial factor for treatment response as assessed by RECIST. |
| format | Article |
| id | doaj-art-db1e778e87f04a2db7cfc5512d055ed0 |
| institution | Kabale University |
| issn | 1561-3046 |
| language | Spanish |
| publishDate | 2022-07-01 |
| publisher | ECIMED |
| record_format | Article |
| series | Revista Cubana de Medicina Militar |
| spelling | doaj-art-db1e778e87f04a2db7cfc5512d055ed02025-01-10T19:04:53ZspaECIMEDRevista Cubana de Medicina Militar1561-30462022-07-01513590The relationship between IDH, P53 mutations, MGMT methylation with characteristics in high grade glioma patientsDuc Anh Tran0https://orcid.org/0000-0002-2355-2006Ba Van Nguyen1https://orcid.org/0000-0001-8603-2035Bac Thanh Nguyen2https://orcid.org/0000-0002-8316-3088Hoe Van Vu3https://orcid.org/0000-0002-2584-861XLien Duc Nguyen4https://orcid.org/0000-0001-7568-1857Vietnam Military Medical UniversityVietnam Military Medical UniversityVietnam Military Medical UniversityVietnam Military Medical UniversityVietnam National Cancer HospitalIntroduction: Some gene mutations in high grade glioma patients have many implications in prognosis and treatment response. Objectives: To describe the characteristics and associations of IDH, TP53 gene mutations and MGMT methylation status with some characteristics and treatment response in patients with high grade glioma. Methods: A descriptive, prospective, uncontrolled study was conducted, in 52 patients with high-grade glioma. Research variables include age, sex, Karnofsky score, the rate of IDH, P53 mutation, MGMT methylation; the relationship between genes mutation with some characteristics and response to treatment according to the RECIST classification. Results: For IDH gene mutation, grade III patients (23.1%) have a higher positive rate than grade IV (11.5 %); for P53 gene mutation, grade III patients (55.6 %) have a higher positive rate than grade IV (44.1 %); the rate of MGMT promoter methylation occurred in the study group of patients with the rate of 42.3 %. There is a relationship between IDH gene mutation with pathological results and malignancy in studied patients. Patients with the mutant expression of the IDH gene, p53, MGMT methylation status had better RECIST responses than patients without these expressions. Conclusion: High-grade glioma mainly occurs in men, over 40 years old. The presence of mutations in IDH, P53 genes, and MGMT methylation status was a beneficial factor for treatment response as assessed by RECIST.https://revmedmilitar.sld.cu/index.php/mil/article/view/2004mutant IDHmutant TP53MGMT methylationhigh grade glioma. |
| spellingShingle | Duc Anh Tran Ba Van Nguyen Bac Thanh Nguyen Hoe Van Vu Lien Duc Nguyen The relationship between IDH, P53 mutations, MGMT methylation with characteristics in high grade glioma patients Revista Cubana de Medicina Militar mutant IDH mutant TP53 MGMT methylation high grade glioma. |
| title | The relationship between IDH, P53 mutations, MGMT methylation with characteristics in high grade glioma patients |
| title_full | The relationship between IDH, P53 mutations, MGMT methylation with characteristics in high grade glioma patients |
| title_fullStr | The relationship between IDH, P53 mutations, MGMT methylation with characteristics in high grade glioma patients |
| title_full_unstemmed | The relationship between IDH, P53 mutations, MGMT methylation with characteristics in high grade glioma patients |
| title_short | The relationship between IDH, P53 mutations, MGMT methylation with characteristics in high grade glioma patients |
| title_sort | relationship between idh p53 mutations mgmt methylation with characteristics in high grade glioma patients |
| topic | mutant IDH mutant TP53 MGMT methylation high grade glioma. |
| url | https://revmedmilitar.sld.cu/index.php/mil/article/view/2004 |
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