Self-assembled nanoparticles in ocular delivery: a comprehensive review
Abstract Ocular nanoparticles are tiny particles designed to deliver drugs to the eye and have increased drug stability, prolonged drug release, and thereby enhanced bioavailability. Nanoparticles utilized in ocular drug delivery include liposomes, polymeric nanoparticles, solid lipid nanoparticles,...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Springer
2025-01-01
|
| Series: | Discover Applied Sciences |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s42452-024-06283-5 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841544392252325888 |
|---|---|
| author | Shanmugam Saraswathi Tenpattinam Sarad Pawar Naik Bukke Praveen Kumar Kusuma Hope Onohuean Mohan Mothilal Umasankar Krishnamaraju Narayana Goruntla Tadele Mekuriya Yadesa |
| author_facet | Shanmugam Saraswathi Tenpattinam Sarad Pawar Naik Bukke Praveen Kumar Kusuma Hope Onohuean Mohan Mothilal Umasankar Krishnamaraju Narayana Goruntla Tadele Mekuriya Yadesa |
| author_sort | Shanmugam Saraswathi Tenpattinam |
| collection | DOAJ |
| description | Abstract Ocular nanoparticles are tiny particles designed to deliver drugs to the eye and have increased drug stability, prolonged drug release, and thereby enhanced bioavailability. Nanoparticles utilized in ocular drug delivery include liposomes, polymeric nanoparticles, solid lipid nanoparticles, nanostructured lipid carriers, dendrimers, and niosomes. Niosomes are non-ionic surfactant-based vesicles that can encapsulate both hydrophilic and lipophilic drugs and are similar to liposomes but are more stable, less toxic, and easier to produce. Niosomes can also be surface-modified with ligands (e.g., antibodies, peptides) to target specific ocular tissues or cells and hence can improve drug penetration through the corneal and conjunctival barriers. Niosomes can bind to the mucin layer of the eye, increasing medication retention time. The encapsulated medicine is released under regulated conditions, allowing therapeutic doses to be maintained for an extended time period. The present study examines niosome-based drug delivery substitutes in ophthalmology, as well as the optimization of nanocarriers for practical use in treating ocular diseases. |
| format | Article |
| id | doaj-art-db19b24906b147ad8106ceb63a7344de |
| institution | Kabale University |
| issn | 3004-9261 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Applied Sciences |
| spelling | doaj-art-db19b24906b147ad8106ceb63a7344de2025-01-12T12:35:04ZengSpringerDiscover Applied Sciences3004-92612025-01-017111910.1007/s42452-024-06283-5Self-assembled nanoparticles in ocular delivery: a comprehensive reviewShanmugam Saraswathi Tenpattinam0Sarad Pawar Naik Bukke1Praveen Kumar Kusuma2Hope Onohuean3Mohan Mothilal4Umasankar Krishnamaraju5Narayana Goruntla6Tadele Mekuriya Yadesa7Department of Pharmaceutics, SRM College of Pharmacy, SRM Institute of Science and TechnologyDepartment of Pharmaceutics and Pharmaceutical Technology, Kampala International, UniversityDepartment of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Delhi Pharmaceutical Sciences and Research UniversityBiopharmaceutic Unit, Department of Pharmacology and Toxicology, Kampala International, UniversityDepartment of Pharmaceutics, SRM College of Pharmacy, SRM Institute of Science and TechnologyDepartment of Pharmaceutics, Krishna Teja Pharmacy CollegeDepartment of Clinical Pharmacy and Pharmacy Practice, Kampala International UniversityDepartment of Clinical Pharmacy and Pharmacy Practice, Kampala International UniversityAbstract Ocular nanoparticles are tiny particles designed to deliver drugs to the eye and have increased drug stability, prolonged drug release, and thereby enhanced bioavailability. Nanoparticles utilized in ocular drug delivery include liposomes, polymeric nanoparticles, solid lipid nanoparticles, nanostructured lipid carriers, dendrimers, and niosomes. Niosomes are non-ionic surfactant-based vesicles that can encapsulate both hydrophilic and lipophilic drugs and are similar to liposomes but are more stable, less toxic, and easier to produce. Niosomes can also be surface-modified with ligands (e.g., antibodies, peptides) to target specific ocular tissues or cells and hence can improve drug penetration through the corneal and conjunctival barriers. Niosomes can bind to the mucin layer of the eye, increasing medication retention time. The encapsulated medicine is released under regulated conditions, allowing therapeutic doses to be maintained for an extended time period. The present study examines niosome-based drug delivery substitutes in ophthalmology, as well as the optimization of nanocarriers for practical use in treating ocular diseases.https://doi.org/10.1007/s42452-024-06283-5NiosomeOcularRetinal barrierNanocarriersDrug deliveryBlood retinal barrier |
| spellingShingle | Shanmugam Saraswathi Tenpattinam Sarad Pawar Naik Bukke Praveen Kumar Kusuma Hope Onohuean Mohan Mothilal Umasankar Krishnamaraju Narayana Goruntla Tadele Mekuriya Yadesa Self-assembled nanoparticles in ocular delivery: a comprehensive review Discover Applied Sciences Niosome Ocular Retinal barrier Nanocarriers Drug delivery Blood retinal barrier |
| title | Self-assembled nanoparticles in ocular delivery: a comprehensive review |
| title_full | Self-assembled nanoparticles in ocular delivery: a comprehensive review |
| title_fullStr | Self-assembled nanoparticles in ocular delivery: a comprehensive review |
| title_full_unstemmed | Self-assembled nanoparticles in ocular delivery: a comprehensive review |
| title_short | Self-assembled nanoparticles in ocular delivery: a comprehensive review |
| title_sort | self assembled nanoparticles in ocular delivery a comprehensive review |
| topic | Niosome Ocular Retinal barrier Nanocarriers Drug delivery Blood retinal barrier |
| url | https://doi.org/10.1007/s42452-024-06283-5 |
| work_keys_str_mv | AT shanmugamsaraswathitenpattinam selfassemblednanoparticlesinoculardeliveryacomprehensivereview AT saradpawarnaikbukke selfassemblednanoparticlesinoculardeliveryacomprehensivereview AT praveenkumarkusuma selfassemblednanoparticlesinoculardeliveryacomprehensivereview AT hopeonohuean selfassemblednanoparticlesinoculardeliveryacomprehensivereview AT mohanmothilal selfassemblednanoparticlesinoculardeliveryacomprehensivereview AT umasankarkrishnamaraju selfassemblednanoparticlesinoculardeliveryacomprehensivereview AT narayanagoruntla selfassemblednanoparticlesinoculardeliveryacomprehensivereview AT tadelemekuriyayadesa selfassemblednanoparticlesinoculardeliveryacomprehensivereview |