Effects of Dimethylaminoethanol and Compound Amino Acid on D-Galactose Induced Skin Aging Model of Rat
A lasting dream of human beings is to reverse or postpone aging. In this study, dimethylaminoethanol (DMAE) and compound amino acid (AA) in Mesotherapy were investigated for their potential antiaging effects on D-galactose induced aging skin. At 18 days after D-gal induction, each rat was treated wi...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/507351 |
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| author | Su Liu Zhenyu Chen Xia Cai Ying Sun Cailing Zhao Fangjun Liu Dalie Liu |
| author_facet | Su Liu Zhenyu Chen Xia Cai Ying Sun Cailing Zhao Fangjun Liu Dalie Liu |
| author_sort | Su Liu |
| collection | DOAJ |
| description | A lasting dream of human beings is to reverse or postpone aging. In this study, dimethylaminoethanol (DMAE) and compound amino acid (AA) in Mesotherapy were investigated for their potential antiaging effects on D-galactose induced aging skin. At 18 days after D-gal induction, each rat was treated with intradermal microinjection of saline, AA, 0.1% DMAE, 0.2% DMAE, 0.1% DMAE + AA, or 0.2% DMAE + AA, respectively. At 42 days after treatment, the skin wound was harvested and assayed. Measurement of epidermal and dermal thickness in 0.1% DMAE + AA and 0.2% DMAE + AA groups appeared significantly thicker than aging control rats. No differences were found in tissue water content among groups. Hydroxyproline in 0.1% DMAE + AA, 0.2% DMAE + AA, and sham control groups was much higher than all other groups. Collagen type I, type III, and MMP-1 expression was highly upregulated in both 0.1% DMAE + AA and 0.2% DMAE + AA groups compared with aging control. In contrast, TIMP-1 expression levels of various aging groups were significantly reduced when compared to sham control. Coinjection of DMAE and AA into target tissue has marked antiaging effects on D-galactose induced skin aging model of rat. |
| format | Article |
| id | doaj-art-db14977d9fc940dea5d40b6d2cf4d5b0 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-db14977d9fc940dea5d40b6d2cf4d5b02025-08-20T03:24:21ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/507351507351Effects of Dimethylaminoethanol and Compound Amino Acid on D-Galactose Induced Skin Aging Model of RatSu Liu0Zhenyu Chen1Xia Cai2Ying Sun3Cailing Zhao4Fangjun Liu5Dalie Liu6Department of Plastic Surgery, Zhujiang Hospital, Southern Medical University, 253 GongYe Middle Avenue, Guangzhou, Guangdong 510280, ChinaDepartment of Plastic and Aesthetic Surgery, The Affiliated Hospital of Medical School, Qingdao University, Qingdao, Shandong 266003, ChinaDepartment of Plastic and Aesthetic Surgery, The Affiliated Hospital of Medical School, Qingdao University, Qingdao, Shandong 266003, ChinaDepartment of Dermatology, Huang-Si Aesthetic Surgery Hospital, Beijing 100120, ChinaDepartment of Plastic and Aesthetic Surgery, The Affiliated Hospital of Medical School, Qingdao University, Qingdao, Shandong 266003, ChinaCenter for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USADepartment of Plastic Surgery, Zhujiang Hospital, Southern Medical University, 253 GongYe Middle Avenue, Guangzhou, Guangdong 510280, ChinaA lasting dream of human beings is to reverse or postpone aging. In this study, dimethylaminoethanol (DMAE) and compound amino acid (AA) in Mesotherapy were investigated for their potential antiaging effects on D-galactose induced aging skin. At 18 days after D-gal induction, each rat was treated with intradermal microinjection of saline, AA, 0.1% DMAE, 0.2% DMAE, 0.1% DMAE + AA, or 0.2% DMAE + AA, respectively. At 42 days after treatment, the skin wound was harvested and assayed. Measurement of epidermal and dermal thickness in 0.1% DMAE + AA and 0.2% DMAE + AA groups appeared significantly thicker than aging control rats. No differences were found in tissue water content among groups. Hydroxyproline in 0.1% DMAE + AA, 0.2% DMAE + AA, and sham control groups was much higher than all other groups. Collagen type I, type III, and MMP-1 expression was highly upregulated in both 0.1% DMAE + AA and 0.2% DMAE + AA groups compared with aging control. In contrast, TIMP-1 expression levels of various aging groups were significantly reduced when compared to sham control. Coinjection of DMAE and AA into target tissue has marked antiaging effects on D-galactose induced skin aging model of rat.http://dx.doi.org/10.1155/2014/507351 |
| spellingShingle | Su Liu Zhenyu Chen Xia Cai Ying Sun Cailing Zhao Fangjun Liu Dalie Liu Effects of Dimethylaminoethanol and Compound Amino Acid on D-Galactose Induced Skin Aging Model of Rat The Scientific World Journal |
| title | Effects of Dimethylaminoethanol and Compound Amino Acid on D-Galactose Induced Skin Aging Model of Rat |
| title_full | Effects of Dimethylaminoethanol and Compound Amino Acid on D-Galactose Induced Skin Aging Model of Rat |
| title_fullStr | Effects of Dimethylaminoethanol and Compound Amino Acid on D-Galactose Induced Skin Aging Model of Rat |
| title_full_unstemmed | Effects of Dimethylaminoethanol and Compound Amino Acid on D-Galactose Induced Skin Aging Model of Rat |
| title_short | Effects of Dimethylaminoethanol and Compound Amino Acid on D-Galactose Induced Skin Aging Model of Rat |
| title_sort | effects of dimethylaminoethanol and compound amino acid on d galactose induced skin aging model of rat |
| url | http://dx.doi.org/10.1155/2014/507351 |
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