Salivary metabolomics in oral cancer: A systematic review
Diagnosis of oral squamous cell carcinoma (OSCC) is frequently delayed, with most tumors being detected in advanced stages.Saliva may represent the ideal fluid for early detection of dysplastic and malignant oral lesions. Among available salivary analytical approaches (e.g., genomic, transcriptomic,...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-09-01
|
| Series: | Oral Oncology Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S277290602400503X |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841553706768662528 |
|---|---|
| author | Rita Antonelli Giacomo Setti Nathaniel S. Treister Thelma A. Pertinhez Elena Ferrari Mariana Gallo Ronell Bologna-Molina Paolo Vescovi Marco Meleti |
| author_facet | Rita Antonelli Giacomo Setti Nathaniel S. Treister Thelma A. Pertinhez Elena Ferrari Mariana Gallo Ronell Bologna-Molina Paolo Vescovi Marco Meleti |
| author_sort | Rita Antonelli |
| collection | DOAJ |
| description | Diagnosis of oral squamous cell carcinoma (OSCC) is frequently delayed, with most tumors being detected in advanced stages.Saliva may represent the ideal fluid for early detection of dysplastic and malignant oral lesions. Among available salivary analytical approaches (e.g., genomic, transcriptomic, proteomic), metabolomics appears promising in identifying the presence of small, specific molecules directly released from malignant cells that could potentially serve as diagnostic biomarkers.This systematic review evaluates the scientific evidence that supports the role of salivary metabolites in the early diagnosis of OSCC.Medline, Scopus and Web of Science databases were searched until February 2024. Two independent reviewers assessed the quality of the studies using a checklist proposed by the National Institutes of Health. They also assessed the level of evidence using the Oxford Center for Evidence-Based Medicine classification.Twenty-eight out of 9623 papers fulfilled the inclusion and exclusion criteria. The quality of the included papers ranged from “good” (n = 2), “intermediate” (n = 22), and “poor” (n = 4).Ten out of 25 studies evaluated one specific metabolite (sialic acid, cortisol, pyruvic acid, neopterine, 8-hydroxy-2-deoxyguanosine and malondialdehyde, endogenous porphyrin, among others), with the remainder analyzing a combination of 2 or more molecules. Overall, the presence and/or concentration of more than 100 salivary metabolites was investigated in association with histologically confirmed diagnosis of OSCC.All studies showed a statistically significant correlation between one or more metabolites and OSCC.These results suggest that metabolic analysis of saliva is a promising field for early diagnosis of OSCC, even though more well-conducted studies are needed. |
| format | Article |
| id | doaj-art-db09ff20896647bfbd46dbedc9f5eac5 |
| institution | Kabale University |
| issn | 2772-9060 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Oral Oncology Reports |
| spelling | doaj-art-db09ff20896647bfbd46dbedc9f5eac52025-01-09T06:17:04ZengElsevierOral Oncology Reports2772-90602024-09-0111100657Salivary metabolomics in oral cancer: A systematic reviewRita Antonelli0Giacomo Setti1Nathaniel S. Treister2Thelma A. Pertinhez3Elena Ferrari4Mariana Gallo5Ronell Bologna-Molina6Paolo Vescovi7Marco Meleti8Centro Universitario di Odontoiatria, Department of Medicine and Surgery, University of Parma, Via Gramsci 14, 43125, Parma, Italy; Corresponding author.Department of Surgical, Medical, Dental and Morphological Science with Interest in Transplant Oncological and Regenerative Medicine, University of Modena and Reggio Emilia, Largo Del Pozzo 71, 41125, Modena, ItalyDepartment of Surgery, Division of Oral Medicine and Dentistry, Brigham and Women's Hospital, Boston, MA, USALaboratory of Biochemistry and Metabolomics, Department of Medicine and Surgery, University of Parma, Via Volturno 39, 43125, Parma, ItalyLaboratory of Biochemistry and Metabolomics, Department of Medicine and Surgery, University of Parma, Via Volturno 39, 43125, Parma, ItalyLaboratory of Biochemistry and Metabolomics, Department of Medicine and Surgery, University of Parma, Via Volturno 39, 43125, Parma, ItalyMolecular Pathology Area, School of Dentistry, Universidad de La República (UDELAR), Montevideo, UruguayCentro Universitario di Odontoiatria, Department of Medicine and Surgery, University of Parma, Via Gramsci 14, 43125, Parma, ItalyCentro Universitario di Odontoiatria, Department of Medicine and Surgery, University of Parma, Via Gramsci 14, 43125, Parma, ItalyDiagnosis of oral squamous cell carcinoma (OSCC) is frequently delayed, with most tumors being detected in advanced stages.Saliva may represent the ideal fluid for early detection of dysplastic and malignant oral lesions. Among available salivary analytical approaches (e.g., genomic, transcriptomic, proteomic), metabolomics appears promising in identifying the presence of small, specific molecules directly released from malignant cells that could potentially serve as diagnostic biomarkers.This systematic review evaluates the scientific evidence that supports the role of salivary metabolites in the early diagnosis of OSCC.Medline, Scopus and Web of Science databases were searched until February 2024. Two independent reviewers assessed the quality of the studies using a checklist proposed by the National Institutes of Health. They also assessed the level of evidence using the Oxford Center for Evidence-Based Medicine classification.Twenty-eight out of 9623 papers fulfilled the inclusion and exclusion criteria. The quality of the included papers ranged from “good” (n = 2), “intermediate” (n = 22), and “poor” (n = 4).Ten out of 25 studies evaluated one specific metabolite (sialic acid, cortisol, pyruvic acid, neopterine, 8-hydroxy-2-deoxyguanosine and malondialdehyde, endogenous porphyrin, among others), with the remainder analyzing a combination of 2 or more molecules. Overall, the presence and/or concentration of more than 100 salivary metabolites was investigated in association with histologically confirmed diagnosis of OSCC.All studies showed a statistically significant correlation between one or more metabolites and OSCC.These results suggest that metabolic analysis of saliva is a promising field for early diagnosis of OSCC, even though more well-conducted studies are needed.http://www.sciencedirect.com/science/article/pii/S277290602400503XSalivary metabolomicsSalivary biomarkersOral squamous cell carcinomaDiagnosis |
| spellingShingle | Rita Antonelli Giacomo Setti Nathaniel S. Treister Thelma A. Pertinhez Elena Ferrari Mariana Gallo Ronell Bologna-Molina Paolo Vescovi Marco Meleti Salivary metabolomics in oral cancer: A systematic review Oral Oncology Reports Salivary metabolomics Salivary biomarkers Oral squamous cell carcinoma Diagnosis |
| title | Salivary metabolomics in oral cancer: A systematic review |
| title_full | Salivary metabolomics in oral cancer: A systematic review |
| title_fullStr | Salivary metabolomics in oral cancer: A systematic review |
| title_full_unstemmed | Salivary metabolomics in oral cancer: A systematic review |
| title_short | Salivary metabolomics in oral cancer: A systematic review |
| title_sort | salivary metabolomics in oral cancer a systematic review |
| topic | Salivary metabolomics Salivary biomarkers Oral squamous cell carcinoma Diagnosis |
| url | http://www.sciencedirect.com/science/article/pii/S277290602400503X |
| work_keys_str_mv | AT ritaantonelli salivarymetabolomicsinoralcancerasystematicreview AT giacomosetti salivarymetabolomicsinoralcancerasystematicreview AT nathanielstreister salivarymetabolomicsinoralcancerasystematicreview AT thelmaapertinhez salivarymetabolomicsinoralcancerasystematicreview AT elenaferrari salivarymetabolomicsinoralcancerasystematicreview AT marianagallo salivarymetabolomicsinoralcancerasystematicreview AT ronellbolognamolina salivarymetabolomicsinoralcancerasystematicreview AT paolovescovi salivarymetabolomicsinoralcancerasystematicreview AT marcomeleti salivarymetabolomicsinoralcancerasystematicreview |