A Review on Current Aspects of Curcumin-Based Effects in Relation to Neurodegenerative, Neuroinflammatory and Cerebrovascular Diseases
Curcumin is among the most well-studied natural substances, known for its biological actions within the central nervous system, its antioxidant and anti-inflammatory properties, and human health benefits. However, challenges persist in effectively utilising curcumin, addressing its metabolism and pa...
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MDPI AG
2024-12-01
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| author | Claudia-Andreea Moldoveanu Maria Tomoaia-Cotisel Alexandra Sevastre-Berghian Gheorghe Tomoaia Aurora Mocanu Csaba Pal-Racz Vlad-Alexandru Toma Ioana Roman Madalina-Anca Ujica Lucian-Cristian Pop |
| author_facet | Claudia-Andreea Moldoveanu Maria Tomoaia-Cotisel Alexandra Sevastre-Berghian Gheorghe Tomoaia Aurora Mocanu Csaba Pal-Racz Vlad-Alexandru Toma Ioana Roman Madalina-Anca Ujica Lucian-Cristian Pop |
| author_sort | Claudia-Andreea Moldoveanu |
| collection | DOAJ |
| description | Curcumin is among the most well-studied natural substances, known for its biological actions within the central nervous system, its antioxidant and anti-inflammatory properties, and human health benefits. However, challenges persist in effectively utilising curcumin, addressing its metabolism and passage through the blood–brain barrier (BBB) in therapies targeting cerebrovascular diseases. Current challenges in curcumin’s applications revolve around its effects within neoplastic tissues alongside the development of intelligent formulations to enhance its bioavailability. Formulations have been discovered including curcumin’s complexes with brain-derived phospholipids and proteins, or its liposomal encapsulation. These novel strategies aim to improve curcumin’s bioavailability and stability, and its capability to cross the BBB, thereby potentially enhancing its efficacy in treating cerebrovascular diseases. In summary, this review provides a comprehensive overview of molecular pathways involved in interactions of curcumin and its metabolites, and brain vascular homeostasis. This review explores cellular and molecular current aspects, of curcumin-based effects with an emphasis on curcumin’s metabolism and its impact on pathological conditions, such as neurodegenerative diseases, schizophrenia, and cerebral angiopathy. It also highlights the limitations posed by curcumin’s poor bioavailability and discusses ongoing efforts to surpass these impediments to harness the full therapeutic potential of curcumin in neurological disorders. |
| format | Article |
| id | doaj-art-dad0aa5ef98740dfa5d387600455352d |
| institution | Kabale University |
| issn | 1420-3049 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-dad0aa5ef98740dfa5d387600455352d2025-01-10T13:18:42ZengMDPI AGMolecules1420-30492024-12-013014310.3390/molecules30010043A Review on Current Aspects of Curcumin-Based Effects in Relation to Neurodegenerative, Neuroinflammatory and Cerebrovascular DiseasesClaudia-Andreea Moldoveanu0Maria Tomoaia-Cotisel1Alexandra Sevastre-Berghian2Gheorghe Tomoaia3Aurora Mocanu4Csaba Pal-Racz5Vlad-Alexandru Toma6Ioana Roman7Madalina-Anca Ujica8Lucian-Cristian Pop9Department of Molecular Biology and Biotechnology, Babeș-Bolyai University, Clinicilor St., RO-400371 Cluj-Napoca, RomaniaResearch Center of Excellence in Physical Chemistry, Faculty of Chemistry and Chemical Engineering, “Babes-Bolyai University”, 11 Arany Janos St., RO-400028 Cluj-Napoca, RomaniaDepartment of Physiology, Faculty of Medicine, “Iuliu Hațieganu” University of Medicine and Pharmacy, 1 Clinicilor St., RO-400006 Cluj-Napoca, RomaniaAcademy of Romanian Scientists, 3 Ilfov St., RO-050044 Bucharest, RomaniaResearch Center of Excellence in Physical Chemistry, Faculty of Chemistry and Chemical Engineering, “Babes-Bolyai University”, 11 Arany Janos St., RO-400028 Cluj-Napoca, RomaniaResearch Center of Excellence in Physical Chemistry, Faculty of Chemistry and Chemical Engineering, “Babes-Bolyai University”, 11 Arany Janos St., RO-400028 Cluj-Napoca, RomaniaDepartment of Molecular Biology and Biotechnology, Babeș-Bolyai University, Clinicilor St., RO-400371 Cluj-Napoca, RomaniaDepartment of Experimental Biology and Biochemistry, Institute of Biological Research from Cluj-Napoca, a Branch of NIRDBS Bucharest, 48 Republicii St., RO-400015 Cluj-Napoca, RomaniaResearch Center of Excellence in Physical Chemistry, Faculty of Chemistry and Chemical Engineering, “Babes-Bolyai University”, 11 Arany Janos St., RO-400028 Cluj-Napoca, RomaniaResearch Center of Excellence in Physical Chemistry, Faculty of Chemistry and Chemical Engineering, “Babes-Bolyai University”, 11 Arany Janos St., RO-400028 Cluj-Napoca, RomaniaCurcumin is among the most well-studied natural substances, known for its biological actions within the central nervous system, its antioxidant and anti-inflammatory properties, and human health benefits. However, challenges persist in effectively utilising curcumin, addressing its metabolism and passage through the blood–brain barrier (BBB) in therapies targeting cerebrovascular diseases. Current challenges in curcumin’s applications revolve around its effects within neoplastic tissues alongside the development of intelligent formulations to enhance its bioavailability. Formulations have been discovered including curcumin’s complexes with brain-derived phospholipids and proteins, or its liposomal encapsulation. These novel strategies aim to improve curcumin’s bioavailability and stability, and its capability to cross the BBB, thereby potentially enhancing its efficacy in treating cerebrovascular diseases. In summary, this review provides a comprehensive overview of molecular pathways involved in interactions of curcumin and its metabolites, and brain vascular homeostasis. This review explores cellular and molecular current aspects, of curcumin-based effects with an emphasis on curcumin’s metabolism and its impact on pathological conditions, such as neurodegenerative diseases, schizophrenia, and cerebral angiopathy. It also highlights the limitations posed by curcumin’s poor bioavailability and discusses ongoing efforts to surpass these impediments to harness the full therapeutic potential of curcumin in neurological disorders.https://www.mdpi.com/1420-3049/30/1/43curcuminbioavailabilityformulations blood–brain barriercerebrovascular diseasesbenefits and limiting effects |
| spellingShingle | Claudia-Andreea Moldoveanu Maria Tomoaia-Cotisel Alexandra Sevastre-Berghian Gheorghe Tomoaia Aurora Mocanu Csaba Pal-Racz Vlad-Alexandru Toma Ioana Roman Madalina-Anca Ujica Lucian-Cristian Pop A Review on Current Aspects of Curcumin-Based Effects in Relation to Neurodegenerative, Neuroinflammatory and Cerebrovascular Diseases Molecules curcumin bioavailability formulations blood–brain barrier cerebrovascular diseases benefits and limiting effects |
| title | A Review on Current Aspects of Curcumin-Based Effects in Relation to Neurodegenerative, Neuroinflammatory and Cerebrovascular Diseases |
| title_full | A Review on Current Aspects of Curcumin-Based Effects in Relation to Neurodegenerative, Neuroinflammatory and Cerebrovascular Diseases |
| title_fullStr | A Review on Current Aspects of Curcumin-Based Effects in Relation to Neurodegenerative, Neuroinflammatory and Cerebrovascular Diseases |
| title_full_unstemmed | A Review on Current Aspects of Curcumin-Based Effects in Relation to Neurodegenerative, Neuroinflammatory and Cerebrovascular Diseases |
| title_short | A Review on Current Aspects of Curcumin-Based Effects in Relation to Neurodegenerative, Neuroinflammatory and Cerebrovascular Diseases |
| title_sort | review on current aspects of curcumin based effects in relation to neurodegenerative neuroinflammatory and cerebrovascular diseases |
| topic | curcumin bioavailability formulations blood–brain barrier cerebrovascular diseases benefits and limiting effects |
| url | https://www.mdpi.com/1420-3049/30/1/43 |
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