Nanoparticles for Biomedical Imaging: Fundamentals of Clinical Translation
Because of their large size compared to small molecules and their multifunctionality, nanoparticles (NPs) hold promise as biomedical imaging, diagnostic, and theragnostic agents. However, the key to their success hinges on a detailed understanding of their behavior after administration into the body...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2010-11-01
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| Series: | Molecular Imaging |
| Online Access: | https://doi.org/10.2310/7290.2010.00031 |
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| _version_ | 1841564133975130112 |
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| author | Hak Soo Choi John V. Frangioni |
| author_facet | Hak Soo Choi John V. Frangioni |
| author_sort | Hak Soo Choi |
| collection | DOAJ |
| description | Because of their large size compared to small molecules and their multifunctionality, nanoparticles (NPs) hold promise as biomedical imaging, diagnostic, and theragnostic agents. However, the key to their success hinges on a detailed understanding of their behavior after administration into the body. NP biodistribution, target binding, and clearance are complex functions of their physicochemical properties in serum, which include hydrodynamic diameter, solubility, stability, shape and flexibility, surface charge, composition, and formulation. Moreover, many materials used to construct NPs have real or potential toxicity or may interfere with other medical tests. In this review, we discuss the design considerations that mediate NP behavior in the body and the fundamental principles that govern clinical translation. By analyzing those nanomaterials that have already received regulatory approval, most of which are actually therapeutic agents, we attempt to predict which types of NPs hold potential as diagnostic agents for biomedical imaging. Finally, using quantum dots as an example, we provide a framework for deciding whether an NP-based agent is the best choice for a particular clinical application. |
| format | Article |
| id | doaj-art-da83eeb6c88441079a167637af6b33c0 |
| institution | Kabale University |
| issn | 1536-0121 |
| language | English |
| publishDate | 2010-11-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Molecular Imaging |
| spelling | doaj-art-da83eeb6c88441079a167637af6b33c02025-01-02T23:11:59ZengSAGE PublishingMolecular Imaging1536-01212010-11-01910.2310/7290.2010.0003110.2310_7290.2010.00031Nanoparticles for Biomedical Imaging: Fundamentals of Clinical TranslationHak Soo ChoiJohn V. FrangioniBecause of their large size compared to small molecules and their multifunctionality, nanoparticles (NPs) hold promise as biomedical imaging, diagnostic, and theragnostic agents. However, the key to their success hinges on a detailed understanding of their behavior after administration into the body. NP biodistribution, target binding, and clearance are complex functions of their physicochemical properties in serum, which include hydrodynamic diameter, solubility, stability, shape and flexibility, surface charge, composition, and formulation. Moreover, many materials used to construct NPs have real or potential toxicity or may interfere with other medical tests. In this review, we discuss the design considerations that mediate NP behavior in the body and the fundamental principles that govern clinical translation. By analyzing those nanomaterials that have already received regulatory approval, most of which are actually therapeutic agents, we attempt to predict which types of NPs hold potential as diagnostic agents for biomedical imaging. Finally, using quantum dots as an example, we provide a framework for deciding whether an NP-based agent is the best choice for a particular clinical application.https://doi.org/10.2310/7290.2010.00031 |
| spellingShingle | Hak Soo Choi John V. Frangioni Nanoparticles for Biomedical Imaging: Fundamentals of Clinical Translation Molecular Imaging |
| title | Nanoparticles for Biomedical Imaging: Fundamentals of Clinical Translation |
| title_full | Nanoparticles for Biomedical Imaging: Fundamentals of Clinical Translation |
| title_fullStr | Nanoparticles for Biomedical Imaging: Fundamentals of Clinical Translation |
| title_full_unstemmed | Nanoparticles for Biomedical Imaging: Fundamentals of Clinical Translation |
| title_short | Nanoparticles for Biomedical Imaging: Fundamentals of Clinical Translation |
| title_sort | nanoparticles for biomedical imaging fundamentals of clinical translation |
| url | https://doi.org/10.2310/7290.2010.00031 |
| work_keys_str_mv | AT haksoochoi nanoparticlesforbiomedicalimagingfundamentalsofclinicaltranslation AT johnvfrangioni nanoparticlesforbiomedicalimagingfundamentalsofclinicaltranslation |