Polygenic risk for epigenetic aging and adverse life experiences interact to predict growth in adolescent depression in a racially/ethnically diverse sample
IntroductionResearch has yet to examine the interplay between indices of environmental risk and resilience processes and genetic predisposition for epigenetic aging in predicting early adolescent depressive symptoms. In the current study we examine whether adverse life events and parental acceptance...
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1499395/full |
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| author | Kit K. Elam Jinni Su Weisiyu Abraham Qin Kathryn Lemery-Chalfant |
| author_facet | Kit K. Elam Jinni Su Weisiyu Abraham Qin Kathryn Lemery-Chalfant |
| author_sort | Kit K. Elam |
| collection | DOAJ |
| description | IntroductionResearch has yet to examine the interplay between indices of environmental risk and resilience processes and genetic predisposition for epigenetic aging in predicting early adolescent depressive symptoms. In the current study we examine whether adverse life events and parental acceptance moderate polygenic predisposition for GrimAge epigenetic aging in predicting trajectories of depressive symptoms across early adolescence.MethodUsing data from the Adolescent Brain Development Study (ABCD, N = 11,875), we created polygenic scores for GrimAge, and examined whether exposure to adverse life events and parental acceptance moderated the relation between genetic risk and depressive symptom trajectories from age 10/11 to 12/13 using growth mixture modelling. We examined models separately in European American (EA), African American (AA), and Latinx (LX) subgroups of ABCD.ResultsIn the EA and AA subgroups, adverse life events moderated polygenic scores for GrimAge such that there was increased likelihood of membership in a higher vs. lower depression trajectory.DiscussionWe extend literature by identifying genetic contributions to epigenetic aging as a depression diathesis in adolescence. Findings also highlight the detrimental role of adverse life events in exacerbating genetic risk for the development of depression in adolescence. |
| format | Article |
| id | doaj-art-da7f5c38c234492785692371b215a6ce |
| institution | Kabale University |
| issn | 1664-0640 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj-art-da7f5c38c234492785692371b215a6ce2024-12-20T06:29:22ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402024-12-011510.3389/fpsyt.2024.14993951499395Polygenic risk for epigenetic aging and adverse life experiences interact to predict growth in adolescent depression in a racially/ethnically diverse sampleKit K. Elam0Jinni Su1Weisiyu Abraham Qin2Kathryn Lemery-Chalfant3Department of Applied Health Science, School of Public Health, Indiana University, Bloomington, IN, United StatesPsychology Department, Arizona State University, Tempe, AZ, United StatesDepartment of Applied Health Science, School of Public Health, Indiana University, Bloomington, IN, United StatesPsychology Department, Arizona State University, Tempe, AZ, United StatesIntroductionResearch has yet to examine the interplay between indices of environmental risk and resilience processes and genetic predisposition for epigenetic aging in predicting early adolescent depressive symptoms. In the current study we examine whether adverse life events and parental acceptance moderate polygenic predisposition for GrimAge epigenetic aging in predicting trajectories of depressive symptoms across early adolescence.MethodUsing data from the Adolescent Brain Development Study (ABCD, N = 11,875), we created polygenic scores for GrimAge, and examined whether exposure to adverse life events and parental acceptance moderated the relation between genetic risk and depressive symptom trajectories from age 10/11 to 12/13 using growth mixture modelling. We examined models separately in European American (EA), African American (AA), and Latinx (LX) subgroups of ABCD.ResultsIn the EA and AA subgroups, adverse life events moderated polygenic scores for GrimAge such that there was increased likelihood of membership in a higher vs. lower depression trajectory.DiscussionWe extend literature by identifying genetic contributions to epigenetic aging as a depression diathesis in adolescence. Findings also highlight the detrimental role of adverse life events in exacerbating genetic risk for the development of depression in adolescence.https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1499395/fullpolygenicepigeneticsdepressionadverse life eventsparent acceptanceearly adolescence |
| spellingShingle | Kit K. Elam Jinni Su Weisiyu Abraham Qin Kathryn Lemery-Chalfant Polygenic risk for epigenetic aging and adverse life experiences interact to predict growth in adolescent depression in a racially/ethnically diverse sample Frontiers in Psychiatry polygenic epigenetics depression adverse life events parent acceptance early adolescence |
| title | Polygenic risk for epigenetic aging and adverse life experiences interact to predict growth in adolescent depression in a racially/ethnically diverse sample |
| title_full | Polygenic risk for epigenetic aging and adverse life experiences interact to predict growth in adolescent depression in a racially/ethnically diverse sample |
| title_fullStr | Polygenic risk for epigenetic aging and adverse life experiences interact to predict growth in adolescent depression in a racially/ethnically diverse sample |
| title_full_unstemmed | Polygenic risk for epigenetic aging and adverse life experiences interact to predict growth in adolescent depression in a racially/ethnically diverse sample |
| title_short | Polygenic risk for epigenetic aging and adverse life experiences interact to predict growth in adolescent depression in a racially/ethnically diverse sample |
| title_sort | polygenic risk for epigenetic aging and adverse life experiences interact to predict growth in adolescent depression in a racially ethnically diverse sample |
| topic | polygenic epigenetics depression adverse life events parent acceptance early adolescence |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1499395/full |
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