Brain Complete Response to Cabozantinib prior to Radiation Therapy in Metastatic Renal Cell Carcinoma
Cabozantinib represents an established vascular endothelial growth factor- (VEGF-) tyrosine kinase inhibitor (TKI) in the treatment paradigm of metastatic renal cell carcinoma (mRCC). Its activity in mRCC patients with brain metastases (BMs) has been largely underreported in prospective clinical tri...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
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| Series: | Case Reports in Urology |
| Online Access: | http://dx.doi.org/10.1155/2019/6769017 |
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| _version_ | 1841524495591931904 |
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| author | An Uche Chad Sila Tad Tanoura James Yeh Neil Bhowmick Edwin Posadas Robert Figlin Jun Gong |
| author_facet | An Uche Chad Sila Tad Tanoura James Yeh Neil Bhowmick Edwin Posadas Robert Figlin Jun Gong |
| author_sort | An Uche |
| collection | DOAJ |
| description | Cabozantinib represents an established vascular endothelial growth factor- (VEGF-) tyrosine kinase inhibitor (TKI) in the treatment paradigm of metastatic renal cell carcinoma (mRCC). Its activity in mRCC patients with brain metastases (BMs) has been largely underreported in prospective clinical trials. We present the unique case of a heavily pretreated mRCC patient with BMs who achieved a brain complete response to cabozantinib prior to receiving radiation therapy. We end with a literature review and discussion of the biologic rationale and growing evidence supporting the intracranial activity of cabozantinib. |
| format | Article |
| id | doaj-art-da745b808a80478e94fe105a667d1545 |
| institution | Kabale University |
| issn | 2090-696X 2090-6978 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Urology |
| spelling | doaj-art-da745b808a80478e94fe105a667d15452025-02-03T05:53:12ZengWileyCase Reports in Urology2090-696X2090-69782019-01-01201910.1155/2019/67690176769017Brain Complete Response to Cabozantinib prior to Radiation Therapy in Metastatic Renal Cell CarcinomaAn Uche0Chad Sila1Tad Tanoura2James Yeh3Neil Bhowmick4Edwin Posadas5Robert Figlin6Jun Gong7Division of Hematology/Oncology, Department of Medicine, Harbor-UCLA Medical Center, 1000 W Carson St, Torrance, CA 90509, USADivision of Hematology/Oncology, Department of Medicine, Harbor-UCLA Medical Center, 1000 W Carson St, Torrance, CA 90509, USADivision of Hematology/Oncology, Department of Medicine, Harbor-UCLA Medical Center, 1000 W Carson St, Torrance, CA 90509, USADivision of Hematology/Oncology, Department of Medicine, Harbor-UCLA Medical Center, 1000 W Carson St, Torrance, CA 90509, USADivision of Hematology/Oncology, Department of Medicine, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, USADivision of Hematology/Oncology, Department of Medicine, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, USADivision of Hematology/Oncology, Department of Medicine, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, USADivision of Hematology/Oncology, Department of Medicine, Cedars-Sinai Medical Center, 8700 Beverly Blvd, AC1042B, Los Angeles, CA 90048, USACabozantinib represents an established vascular endothelial growth factor- (VEGF-) tyrosine kinase inhibitor (TKI) in the treatment paradigm of metastatic renal cell carcinoma (mRCC). Its activity in mRCC patients with brain metastases (BMs) has been largely underreported in prospective clinical trials. We present the unique case of a heavily pretreated mRCC patient with BMs who achieved a brain complete response to cabozantinib prior to receiving radiation therapy. We end with a literature review and discussion of the biologic rationale and growing evidence supporting the intracranial activity of cabozantinib.http://dx.doi.org/10.1155/2019/6769017 |
| spellingShingle | An Uche Chad Sila Tad Tanoura James Yeh Neil Bhowmick Edwin Posadas Robert Figlin Jun Gong Brain Complete Response to Cabozantinib prior to Radiation Therapy in Metastatic Renal Cell Carcinoma Case Reports in Urology |
| title | Brain Complete Response to Cabozantinib prior to Radiation Therapy in Metastatic Renal Cell Carcinoma |
| title_full | Brain Complete Response to Cabozantinib prior to Radiation Therapy in Metastatic Renal Cell Carcinoma |
| title_fullStr | Brain Complete Response to Cabozantinib prior to Radiation Therapy in Metastatic Renal Cell Carcinoma |
| title_full_unstemmed | Brain Complete Response to Cabozantinib prior to Radiation Therapy in Metastatic Renal Cell Carcinoma |
| title_short | Brain Complete Response to Cabozantinib prior to Radiation Therapy in Metastatic Renal Cell Carcinoma |
| title_sort | brain complete response to cabozantinib prior to radiation therapy in metastatic renal cell carcinoma |
| url | http://dx.doi.org/10.1155/2019/6769017 |
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