Synthesis and Physicochemical Characteristics of 6,6-Difluorobicyclo[3.2.0]heptane Derivatives

Synthesis and Physicochemical Characteristics of 6,6-Difluorobicyclo[3.2.0]heptane Derivatives

The gram-scale synthesis of 6,6-difluorobicyclo[3.2.0]heptane-derived building blocks (i.e., primary amine and carboxylic acid) was performed via the deoxofluorination of the corresponding bicyclic keto ester with diethylaminosulfur trifluride (DAST). Physicochemical properties of the compounds obta...

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Bibliographic Details
Main Authors: Bohdan L. Moroz, Serhii M. Holovach, Kostiantyn P. Melnykov, Dmytro S. Lesyk, Andriy A. Filatov, Oleksandr O. Grygorenko
Format: Article
Language:English
Published: National University of Pharmacy (Kharkiv) 2024-12-01
Series:Журнал органічної та фармацевтичної хімії
Subjects:
fluorine
bicyclic compounds
acidity
lipophilicity
building blocks
Online Access:https://ophcj.nuph.edu.ua/article/view/314176
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