Clinical Manifestations, Prognostic Factors, and Outcomes of Extranodal Natural Killer T-Cell Lymphoma: A Single-Center Experience in Thailand
<b>Background/Objectives</b>: The primary objective of this study was to investigate clinical manifestations, time to diagnosis, and number of biopsies in patients with extranodal natural killer T-cell lymphoma (ENKTL). The secondary objectives were to determine response rates, survival...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-11-01
|
| Series: | Hematology Reports |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2038-8330/16/4/73 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846104460847218688 |
|---|---|
| author | Wasinee Kaewboot Lalita Norasetthada Adisak Tantiworawit Chatree Chai-Adisaksopha Sasinee Hantrakool Thanawat Rattanathammethee Pokpong Piriyakhuntorn Nonthakorn Hantrakun Teerachat Punnachet Ekarat Rattarittamrong |
| author_facet | Wasinee Kaewboot Lalita Norasetthada Adisak Tantiworawit Chatree Chai-Adisaksopha Sasinee Hantrakool Thanawat Rattanathammethee Pokpong Piriyakhuntorn Nonthakorn Hantrakun Teerachat Punnachet Ekarat Rattarittamrong |
| author_sort | Wasinee Kaewboot |
| collection | DOAJ |
| description | <b>Background/Objectives</b>: The primary objective of this study was to investigate clinical manifestations, time to diagnosis, and number of biopsies in patients with extranodal natural killer T-cell lymphoma (ENKTL). The secondary objectives were to determine response rates, survival outcomes, prognostic factor for overall survival (OS), and validation of the Prognostic Index of Natural Killer Lymphoma (PINK), Ann Arbor staging system (AASS), and the CA system. <b>Methods</b>: This retrospective study included data pertaining to patients with newly diagnosed ENKTL in Chiang-Mai University Hospital from 2004 to 2020. Comparisons between the areas under the receiver operating characteristic curve (AUC) of prognostic models (PINK, AASS, and CA system) were made. <b>Results</b>: Sixty patients were enrolled (n = 60) with a mean age of 49.1 ± 13.4 years. The most frequent symptom of ENKTL was nasal obstruction (66%). The median time to diagnosis was 22 days (ranging from 3 to 84 days), with 36.7% requiring more than one biopsy for diagnosis. Most patients presented with limited stage disease (75%). The median OS was 49 months. Factors associated with increased mortality were advanced stage, bone marrow involvement, gastrointestinal tract involvement, and receiving chemotherapy. Following prognostic model validation, the CA system model scored the highest level of accuracy (AUC 0.61), followed by AASS (AUC 0.58) and PINK (AUC 0.54). <b>Conclusions</b>: Patients with ENKTL commonly presented with nasal obstruction, with 36.7% requiring more than one biopsy for diagnosis. An advanced stage, bone marrow involvement, or gastrointestinal tract involvement were associated with poor OS. The CA system model has the highest level of accuracy for prognostic determination. |
| format | Article |
| id | doaj-art-da326f7670e64d88897d6e0f82d26332 |
| institution | Kabale University |
| issn | 2038-8330 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Hematology Reports |
| spelling | doaj-art-da326f7670e64d88897d6e0f82d263322024-12-27T14:28:43ZengMDPI AGHematology Reports2038-83302024-11-0116476978010.3390/hematolrep16040073Clinical Manifestations, Prognostic Factors, and Outcomes of Extranodal Natural Killer T-Cell Lymphoma: A Single-Center Experience in ThailandWasinee Kaewboot0Lalita Norasetthada1Adisak Tantiworawit2Chatree Chai-Adisaksopha3Sasinee Hantrakool4Thanawat Rattanathammethee5Pokpong Piriyakhuntorn6Nonthakorn Hantrakun7Teerachat Punnachet8Ekarat Rattarittamrong9Department of Internal Medicine, Faculty of Medicine, Chiang-Mai University, Chiang-Mai 50200, ThailandDepartment of Internal Medicine, Faculty of Medicine, Chiang-Mai University, Chiang-Mai 50200, ThailandDepartment of Internal Medicine, Faculty of Medicine, Chiang-Mai University, Chiang-Mai 50200, ThailandDepartment of Internal Medicine, Faculty of Medicine, Chiang-Mai University, Chiang-Mai 50200, ThailandDepartment of Internal Medicine, Faculty of Medicine, Chiang-Mai University, Chiang-Mai 50200, ThailandDepartment of Internal Medicine, Faculty of Medicine, Chiang-Mai University, Chiang-Mai 50200, ThailandDepartment of Internal Medicine, Faculty of Medicine, Chiang-Mai University, Chiang-Mai 50200, ThailandDepartment of Internal Medicine, Faculty of Medicine, Chiang-Mai University, Chiang-Mai 50200, ThailandDepartment of Internal Medicine, Faculty of Medicine, Chiang-Mai University, Chiang-Mai 50200, ThailandDepartment of Internal Medicine, Faculty of Medicine, Chiang-Mai University, Chiang-Mai 50200, Thailand<b>Background/Objectives</b>: The primary objective of this study was to investigate clinical manifestations, time to diagnosis, and number of biopsies in patients with extranodal natural killer T-cell lymphoma (ENKTL). The secondary objectives were to determine response rates, survival outcomes, prognostic factor for overall survival (OS), and validation of the Prognostic Index of Natural Killer Lymphoma (PINK), Ann Arbor staging system (AASS), and the CA system. <b>Methods</b>: This retrospective study included data pertaining to patients with newly diagnosed ENKTL in Chiang-Mai University Hospital from 2004 to 2020. Comparisons between the areas under the receiver operating characteristic curve (AUC) of prognostic models (PINK, AASS, and CA system) were made. <b>Results</b>: Sixty patients were enrolled (n = 60) with a mean age of 49.1 ± 13.4 years. The most frequent symptom of ENKTL was nasal obstruction (66%). The median time to diagnosis was 22 days (ranging from 3 to 84 days), with 36.7% requiring more than one biopsy for diagnosis. Most patients presented with limited stage disease (75%). The median OS was 49 months. Factors associated with increased mortality were advanced stage, bone marrow involvement, gastrointestinal tract involvement, and receiving chemotherapy. Following prognostic model validation, the CA system model scored the highest level of accuracy (AUC 0.61), followed by AASS (AUC 0.58) and PINK (AUC 0.54). <b>Conclusions</b>: Patients with ENKTL commonly presented with nasal obstruction, with 36.7% requiring more than one biopsy for diagnosis. An advanced stage, bone marrow involvement, or gastrointestinal tract involvement were associated with poor OS. The CA system model has the highest level of accuracy for prognostic determination.https://www.mdpi.com/2038-8330/16/4/73extranodal NK/T-cell lymphomaprognostic index of natural killer lymphomaAnn Arbor staging systemCA system |
| spellingShingle | Wasinee Kaewboot Lalita Norasetthada Adisak Tantiworawit Chatree Chai-Adisaksopha Sasinee Hantrakool Thanawat Rattanathammethee Pokpong Piriyakhuntorn Nonthakorn Hantrakun Teerachat Punnachet Ekarat Rattarittamrong Clinical Manifestations, Prognostic Factors, and Outcomes of Extranodal Natural Killer T-Cell Lymphoma: A Single-Center Experience in Thailand Hematology Reports extranodal NK/T-cell lymphoma prognostic index of natural killer lymphoma Ann Arbor staging system CA system |
| title | Clinical Manifestations, Prognostic Factors, and Outcomes of Extranodal Natural Killer T-Cell Lymphoma: A Single-Center Experience in Thailand |
| title_full | Clinical Manifestations, Prognostic Factors, and Outcomes of Extranodal Natural Killer T-Cell Lymphoma: A Single-Center Experience in Thailand |
| title_fullStr | Clinical Manifestations, Prognostic Factors, and Outcomes of Extranodal Natural Killer T-Cell Lymphoma: A Single-Center Experience in Thailand |
| title_full_unstemmed | Clinical Manifestations, Prognostic Factors, and Outcomes of Extranodal Natural Killer T-Cell Lymphoma: A Single-Center Experience in Thailand |
| title_short | Clinical Manifestations, Prognostic Factors, and Outcomes of Extranodal Natural Killer T-Cell Lymphoma: A Single-Center Experience in Thailand |
| title_sort | clinical manifestations prognostic factors and outcomes of extranodal natural killer t cell lymphoma a single center experience in thailand |
| topic | extranodal NK/T-cell lymphoma prognostic index of natural killer lymphoma Ann Arbor staging system CA system |
| url | https://www.mdpi.com/2038-8330/16/4/73 |
| work_keys_str_mv | AT wasineekaewboot clinicalmanifestationsprognosticfactorsandoutcomesofextranodalnaturalkillertcelllymphomaasinglecenterexperienceinthailand AT lalitanorasetthada clinicalmanifestationsprognosticfactorsandoutcomesofextranodalnaturalkillertcelllymphomaasinglecenterexperienceinthailand AT adisaktantiworawit clinicalmanifestationsprognosticfactorsandoutcomesofextranodalnaturalkillertcelllymphomaasinglecenterexperienceinthailand AT chatreechaiadisaksopha clinicalmanifestationsprognosticfactorsandoutcomesofextranodalnaturalkillertcelllymphomaasinglecenterexperienceinthailand AT sasineehantrakool clinicalmanifestationsprognosticfactorsandoutcomesofextranodalnaturalkillertcelllymphomaasinglecenterexperienceinthailand AT thanawatrattanathammethee clinicalmanifestationsprognosticfactorsandoutcomesofextranodalnaturalkillertcelllymphomaasinglecenterexperienceinthailand AT pokpongpiriyakhuntorn clinicalmanifestationsprognosticfactorsandoutcomesofextranodalnaturalkillertcelllymphomaasinglecenterexperienceinthailand AT nonthakornhantrakun clinicalmanifestationsprognosticfactorsandoutcomesofextranodalnaturalkillertcelllymphomaasinglecenterexperienceinthailand AT teerachatpunnachet clinicalmanifestationsprognosticfactorsandoutcomesofextranodalnaturalkillertcelllymphomaasinglecenterexperienceinthailand AT ekaratrattarittamrong clinicalmanifestationsprognosticfactorsandoutcomesofextranodalnaturalkillertcelllymphomaasinglecenterexperienceinthailand |