Assortment of GABAergic Plasticity in the Cortical Interneuron Melting Pot
Cortical structures of the adult mammalian brain are characterized by a spectacular diversity of inhibitory interneurons, which use GABA as neurotransmitter. GABAergic neurotransmission is fundamental for integrating and filtering incoming information and dictating postsynaptic neuronal spike timing...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2011/976856 |
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| author | Pablo Méndez Alberto Bacci |
| author_facet | Pablo Méndez Alberto Bacci |
| author_sort | Pablo Méndez |
| collection | DOAJ |
| description | Cortical structures of the adult mammalian brain are characterized by a spectacular diversity of inhibitory interneurons, which use GABA as neurotransmitter. GABAergic neurotransmission is fundamental for integrating and filtering incoming information and dictating postsynaptic neuronal spike timing, therefore providing a tight temporal code used by each neuron, or ensemble of neurons, to perform sophisticated computational operations. However, the heterogeneity of cortical GABAergic cells is associated to equally diverse properties governing intrinsic excitability as well as strength, dynamic range, spatial extent, anatomical localization, and molecular components of inhibitory synaptic connections that they form with pyramidal neurons. Recent studies showed that similarly to their excitatory (glutamatergic) counterparts, also inhibitory synapses can undergo activity-dependent changes in their strength. Here, some aspects related to plasticity and modulation of adult cortical and hippocampal GABAergic synaptic transmission will be reviewed, aiming at providing a fresh perspective towards the elucidation of the role played by specific cellular elements of cortical microcircuits during both physiological and pathological operations. |
| format | Article |
| id | doaj-art-da31e3b337704af5813e50d04bf239e5 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-da31e3b337704af5813e50d04bf239e52025-02-03T05:47:18ZengWileyNeural Plasticity2090-59041687-54432011-01-01201110.1155/2011/976856976856Assortment of GABAergic Plasticity in the Cortical Interneuron Melting PotPablo Méndez0Alberto Bacci1European Brain Research Institute (EBRI), Via del Fosso di Fiorano 64, 00143 Rome, ItalyEuropean Brain Research Institute (EBRI), Via del Fosso di Fiorano 64, 00143 Rome, ItalyCortical structures of the adult mammalian brain are characterized by a spectacular diversity of inhibitory interneurons, which use GABA as neurotransmitter. GABAergic neurotransmission is fundamental for integrating and filtering incoming information and dictating postsynaptic neuronal spike timing, therefore providing a tight temporal code used by each neuron, or ensemble of neurons, to perform sophisticated computational operations. However, the heterogeneity of cortical GABAergic cells is associated to equally diverse properties governing intrinsic excitability as well as strength, dynamic range, spatial extent, anatomical localization, and molecular components of inhibitory synaptic connections that they form with pyramidal neurons. Recent studies showed that similarly to their excitatory (glutamatergic) counterparts, also inhibitory synapses can undergo activity-dependent changes in their strength. Here, some aspects related to plasticity and modulation of adult cortical and hippocampal GABAergic synaptic transmission will be reviewed, aiming at providing a fresh perspective towards the elucidation of the role played by specific cellular elements of cortical microcircuits during both physiological and pathological operations.http://dx.doi.org/10.1155/2011/976856 |
| spellingShingle | Pablo Méndez Alberto Bacci Assortment of GABAergic Plasticity in the Cortical Interneuron Melting Pot Neural Plasticity |
| title | Assortment of GABAergic Plasticity in the Cortical Interneuron Melting Pot |
| title_full | Assortment of GABAergic Plasticity in the Cortical Interneuron Melting Pot |
| title_fullStr | Assortment of GABAergic Plasticity in the Cortical Interneuron Melting Pot |
| title_full_unstemmed | Assortment of GABAergic Plasticity in the Cortical Interneuron Melting Pot |
| title_short | Assortment of GABAergic Plasticity in the Cortical Interneuron Melting Pot |
| title_sort | assortment of gabaergic plasticity in the cortical interneuron melting pot |
| url | http://dx.doi.org/10.1155/2011/976856 |
| work_keys_str_mv | AT pablomendez assortmentofgabaergicplasticityinthecorticalinterneuronmeltingpot AT albertobacci assortmentofgabaergicplasticityinthecorticalinterneuronmeltingpot |