Water Maceration of Black Mahlab Effectively Inhibits the Growth of Staphylococcus aureus Associated with Skin Infections
Background: With the rising risk of antibiotic resistance, our ability to combat Staphylococcus aureus (S. aureus) in skin and soft tissue infections (SSTIs) is being compromised. Purpose: This study aimed to determine the activity of several aqueous extracts of black mahlab seeds (maceration, infus...
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| Format: | Article |
| Language: | Indonesian |
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Department of Dermatology and Venereology, Faculty of Medicine, Universitas Airlangga
2024-11-01
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| Series: | Berkala Ilmu Kesehatan Kulit dan Kelamin (Periodical of Dermatology and Venerology) |
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| Online Access: | https://e-journal.unair.ac.id/BIKK/article/view/57222 |
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| _version_ | 1846140805134155776 |
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| author | Murtada Ahmed Mohmmed Oshi |
| author_facet | Murtada Ahmed Mohmmed Oshi |
| author_sort | Murtada Ahmed Mohmmed Oshi |
| collection | DOAJ |
| description | Background: With the rising risk of antibiotic resistance, our ability to combat Staphylococcus aureus (S. aureus) in skin and soft tissue infections (SSTIs) is being compromised. Purpose: This study aimed to determine the activity of several aqueous extracts of black mahlab seeds (maceration, infusion, and decoction) against S. aureus-associated SSTIs. Methods: We employed the disc diffusion Kirby-Bauer method to evaluate the anti-staphylococcal activity of the extracts. Furthermore, we used various extract concentrations to calculate each extract's minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) against S. aureus. Result: The results revealed enhanced anti-staphylococcal activity, with inhibition zones measuring 11.5, 22.5, and 26.5 mm at concentrations of 25, 50, and 100 mg/ml, respectively. These effects were similar to ampicillin against S. aureus and significantly higher (p 0.05) than gentamicin. The extracts showed antibacterial activity with MICs and MBCs ranging from 12.5 to 25 mg/ml. Conclusion: Overall, compared to the clinically prescribed antibiotics, ampicillin, and gentamicin, black mahlab seed extract obtained by water maceration exhibits increased anti-staphylococcal activity associated with SSTIs. |
| format | Article |
| id | doaj-art-da30961dcffb4c5587f65b615c6d25e6 |
| institution | Kabale University |
| issn | 1978-4279 2549-4082 |
| language | Indonesian |
| publishDate | 2024-11-01 |
| publisher | Department of Dermatology and Venereology, Faculty of Medicine, Universitas Airlangga |
| record_format | Article |
| series | Berkala Ilmu Kesehatan Kulit dan Kelamin (Periodical of Dermatology and Venerology) |
| spelling | doaj-art-da30961dcffb4c5587f65b615c6d25e62024-12-05T04:49:18ZindDepartment of Dermatology and Venereology, Faculty of Medicine, Universitas AirlanggaBerkala Ilmu Kesehatan Kulit dan Kelamin (Periodical of Dermatology and Venerology)1978-42792549-40822024-11-0136320721210.20473/bikk.V36.3.2024.207-21255387Water Maceration of Black Mahlab Effectively Inhibits the Growth of Staphylococcus aureus Associated with Skin InfectionsMurtada Ahmed Mohmmed Oshi0https://orcid.org/0000-0002-3084-2706Department of Pharmaceutics, Faculty of Pharmacy, Omdurman Islamic University, Omdurman, SudanBackground: With the rising risk of antibiotic resistance, our ability to combat Staphylococcus aureus (S. aureus) in skin and soft tissue infections (SSTIs) is being compromised. Purpose: This study aimed to determine the activity of several aqueous extracts of black mahlab seeds (maceration, infusion, and decoction) against S. aureus-associated SSTIs. Methods: We employed the disc diffusion Kirby-Bauer method to evaluate the anti-staphylococcal activity of the extracts. Furthermore, we used various extract concentrations to calculate each extract's minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) against S. aureus. Result: The results revealed enhanced anti-staphylococcal activity, with inhibition zones measuring 11.5, 22.5, and 26.5 mm at concentrations of 25, 50, and 100 mg/ml, respectively. These effects were similar to ampicillin against S. aureus and significantly higher (p 0.05) than gentamicin. The extracts showed antibacterial activity with MICs and MBCs ranging from 12.5 to 25 mg/ml. Conclusion: Overall, compared to the clinically prescribed antibiotics, ampicillin, and gentamicin, black mahlab seed extract obtained by water maceration exhibits increased anti-staphylococcal activity associated with SSTIs.https://e-journal.unair.ac.id/BIKK/article/view/57222antibiotic resistanceblack mahlabgentamicinmacerationstaphylococcus aureus |
| spellingShingle | Murtada Ahmed Mohmmed Oshi Water Maceration of Black Mahlab Effectively Inhibits the Growth of Staphylococcus aureus Associated with Skin Infections Berkala Ilmu Kesehatan Kulit dan Kelamin (Periodical of Dermatology and Venerology) antibiotic resistance black mahlab gentamicin maceration staphylococcus aureus |
| title | Water Maceration of Black Mahlab Effectively Inhibits the Growth of Staphylococcus aureus Associated with Skin Infections |
| title_full | Water Maceration of Black Mahlab Effectively Inhibits the Growth of Staphylococcus aureus Associated with Skin Infections |
| title_fullStr | Water Maceration of Black Mahlab Effectively Inhibits the Growth of Staphylococcus aureus Associated with Skin Infections |
| title_full_unstemmed | Water Maceration of Black Mahlab Effectively Inhibits the Growth of Staphylococcus aureus Associated with Skin Infections |
| title_short | Water Maceration of Black Mahlab Effectively Inhibits the Growth of Staphylococcus aureus Associated with Skin Infections |
| title_sort | water maceration of black mahlab effectively inhibits the growth of staphylococcus aureus associated with skin infections |
| topic | antibiotic resistance black mahlab gentamicin maceration staphylococcus aureus |
| url | https://e-journal.unair.ac.id/BIKK/article/view/57222 |
| work_keys_str_mv | AT murtadaahmedmohmmedoshi watermacerationofblackmahlabeffectivelyinhibitsthegrowthofstaphylococcusaureusassociatedwithskininfections |