Caribbean Consortium for Research in Environmental and Occupational Health (CCREOH) Cohort Study: influences of complex environmental exposures on maternal and child health in Suriname
Purpose The Caribbean Consortium for Research in Environmental and Occupational Health prospective environmental epidemiologic cohort study addresses the impact of chemical and non-chemical environmental exposures on mother/child dyads in Suriname. The study determines associations between levels of...
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BMJ Publishing Group
2020-09-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/10/9/e034702.full |
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| author | Antoon W Grünberg William Hawkins Wilco Zijlmans Jeffrey Wickliffe Ashna Hindori-Mohangoo Sigrid MacDonald-Ottevanger Paul Ouboter Gwendolyn Landburg John Codrington Jimmy Roosblad Gaitree Baldewsingh Radha Ramjatan Anisma Gokoel Firoz Abdoel Wahid Lissa Fortes Soares Cecilia Alcala Esther Boedhoe Arti Shankar Emily Harville S S Drury Hannah Covert Maureen Lichtveld |
| author_facet | Antoon W Grünberg William Hawkins Wilco Zijlmans Jeffrey Wickliffe Ashna Hindori-Mohangoo Sigrid MacDonald-Ottevanger Paul Ouboter Gwendolyn Landburg John Codrington Jimmy Roosblad Gaitree Baldewsingh Radha Ramjatan Anisma Gokoel Firoz Abdoel Wahid Lissa Fortes Soares Cecilia Alcala Esther Boedhoe Arti Shankar Emily Harville S S Drury Hannah Covert Maureen Lichtveld |
| author_sort | Antoon W Grünberg |
| collection | DOAJ |
| description | Purpose The Caribbean Consortium for Research in Environmental and Occupational Health prospective environmental epidemiologic cohort study addresses the impact of chemical and non-chemical environmental exposures on mother/child dyads in Suriname. The study determines associations between levels of environmental elements and toxicants in pregnant women, and birth outcomes and neurodevelopment in their children.Participants Pregnant women (N=1143) were enrolled from December 2016 to July 2019 from three regions of Suriname: Paramaribo (N=738), Nickerie (N=204) and the tropical rainforest interior (N=201). Infants (N=992) were enrolled at birth. Follow-up will take place until children are 48 months old.Findings to date Biospecimens and questionnaire data on physiological and psychosocial health in pregnant women have been analysed. 39.1% had hair mercury (Hg) levels exceeding values considered safe by international standards. Median hair Hg concentrations in women from Paramaribo (N=522) were 0.64 µg/g hair (IQRs 0.36–1.09; range 0.00–7.12), from Nickerie (N=176) 0.73 µg/g (IQR 0.45–1.05; range 0.00–5.79) and the interior (N=178) 3.48 µg/g (IQR 1.92–7.39; range 0.38–18.20). 96.1% of women ate fish, respective consumption of the three most consumed carnivorous species, Hoplias aimara, Serrasalmus rhombeus and Cichla ocellaris, known to have high Hg levels, was 44.4%, 19.3% and 26.3%, respectively, and was greater among the interior subcohort. 89% frequently consumed the vegetable tannia, samples of which showed presence of worldwide banned pesticides. 24.9% of pregnant women had Edinburgh Depression Scale scores indicative of probable depression.Future plans Fish consumption advisories are in development, especially relevant to interior women for whom fish consumption is likely to be the primary source of Hg exposure. Effects of potentially beneficial neuroprotective factors in fish that may counter neurotoxic effects of Hg are being examined. A pesticide literacy assessment in pregnant women is in progress. Neurodevelopmental assessments and telomere length measurements of the children to evaluate long-term effects of prenatal exposures to toxicant mixtures are ongoing. |
| format | Article |
| id | doaj-art-da29ee5559074887b69589580ca22f9e |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2020-09-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-da29ee5559074887b69589580ca22f9e2025-01-08T06:50:08ZengBMJ Publishing GroupBMJ Open2044-60552020-09-0110910.1136/bmjopen-2019-034702Caribbean Consortium for Research in Environmental and Occupational Health (CCREOH) Cohort Study: influences of complex environmental exposures on maternal and child health in SurinameAntoon W Grünberg0William Hawkins1Wilco Zijlmans2Jeffrey Wickliffe3Ashna Hindori-Mohangoo4Sigrid MacDonald-Ottevanger5Paul Ouboter6Gwendolyn Landburg7John Codrington8Jimmy Roosblad9Gaitree Baldewsingh10Radha Ramjatan11Anisma Gokoel12Firoz Abdoel Wahid13Lissa Fortes Soares14Cecilia Alcala15Esther Boedhoe16Arti Shankar17Emily Harville18S S Drury19Hannah Covert20Maureen Lichtveld212Department of Public Health, Ministry of Health, Paramaribo, SurinameDepartment of Environmental Health Sciences, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, United States of AmericaFaculty of Medical Sciences, Pediatrics, Anton de Kom University of Suriname, Paramaribo, SurinameDepartment of Environmental Health Sciences, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, United States of AmericaDepartment of Environmental Health Sciences, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, United States of AmericaScientific Research Center Suriname, Academic Hospital Paramaribo, Paramaribo, SurinameInstitute for Neotropical Wildlife & Environmental Studies, Paramaribo, SurinameNational Zoological Collection of Suriname/Center for Environmental Research, Anton de Kom University of Suriname, Paramaribo, SurinameDepartment of Clinical Chemistry, Academic Hospital Paramaribo, Paramaribo, SurinameFaculty of Medical Sciences, Pediatrics, Anton de Kom University of Suriname, Paramaribo, SurinameFaculty of Medical Sciences, Pediatrics, Anton de Kom University of Suriname, Paramaribo, SurinameFaculty of Medical Sciences, Pediatrics, Anton de Kom University of Suriname, Paramaribo, SurinameFaculty of Medical Sciences, Pediatrics, Anton de Kom University of Suriname, Paramaribo, SurinameDepartment of Environmental Health Sciences, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, United States of AmericaDepartment of Environmental Health Sciences, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, United States of AmericaDepartment of Environmental Health Sciences, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, United States of AmericaScientific Research Center Suriname, Academic Hospital Paramaribo, Paramaribo, SurinameDepartment of Environmental Health Sciences, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, United States of AmericaEpidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USADepartment of Psychiatry and Behavioral Sciences, Tulane University, New Orleans, Louisiana, USADepartment of Environmental Health Sciences, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, United States of AmericaDepartment of Environmental Health Sciences, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, United States of AmericaPurpose The Caribbean Consortium for Research in Environmental and Occupational Health prospective environmental epidemiologic cohort study addresses the impact of chemical and non-chemical environmental exposures on mother/child dyads in Suriname. The study determines associations between levels of environmental elements and toxicants in pregnant women, and birth outcomes and neurodevelopment in their children.Participants Pregnant women (N=1143) were enrolled from December 2016 to July 2019 from three regions of Suriname: Paramaribo (N=738), Nickerie (N=204) and the tropical rainforest interior (N=201). Infants (N=992) were enrolled at birth. Follow-up will take place until children are 48 months old.Findings to date Biospecimens and questionnaire data on physiological and psychosocial health in pregnant women have been analysed. 39.1% had hair mercury (Hg) levels exceeding values considered safe by international standards. Median hair Hg concentrations in women from Paramaribo (N=522) were 0.64 µg/g hair (IQRs 0.36–1.09; range 0.00–7.12), from Nickerie (N=176) 0.73 µg/g (IQR 0.45–1.05; range 0.00–5.79) and the interior (N=178) 3.48 µg/g (IQR 1.92–7.39; range 0.38–18.20). 96.1% of women ate fish, respective consumption of the three most consumed carnivorous species, Hoplias aimara, Serrasalmus rhombeus and Cichla ocellaris, known to have high Hg levels, was 44.4%, 19.3% and 26.3%, respectively, and was greater among the interior subcohort. 89% frequently consumed the vegetable tannia, samples of which showed presence of worldwide banned pesticides. 24.9% of pregnant women had Edinburgh Depression Scale scores indicative of probable depression.Future plans Fish consumption advisories are in development, especially relevant to interior women for whom fish consumption is likely to be the primary source of Hg exposure. Effects of potentially beneficial neuroprotective factors in fish that may counter neurotoxic effects of Hg are being examined. A pesticide literacy assessment in pregnant women is in progress. Neurodevelopmental assessments and telomere length measurements of the children to evaluate long-term effects of prenatal exposures to toxicant mixtures are ongoing.https://bmjopen.bmj.com/content/10/9/e034702.full |
| spellingShingle | Antoon W Grünberg William Hawkins Wilco Zijlmans Jeffrey Wickliffe Ashna Hindori-Mohangoo Sigrid MacDonald-Ottevanger Paul Ouboter Gwendolyn Landburg John Codrington Jimmy Roosblad Gaitree Baldewsingh Radha Ramjatan Anisma Gokoel Firoz Abdoel Wahid Lissa Fortes Soares Cecilia Alcala Esther Boedhoe Arti Shankar Emily Harville S S Drury Hannah Covert Maureen Lichtveld Caribbean Consortium for Research in Environmental and Occupational Health (CCREOH) Cohort Study: influences of complex environmental exposures on maternal and child health in Suriname BMJ Open |
| title | Caribbean Consortium for Research in Environmental and Occupational Health (CCREOH) Cohort Study: influences of complex environmental exposures on maternal and child health in Suriname |
| title_full | Caribbean Consortium for Research in Environmental and Occupational Health (CCREOH) Cohort Study: influences of complex environmental exposures on maternal and child health in Suriname |
| title_fullStr | Caribbean Consortium for Research in Environmental and Occupational Health (CCREOH) Cohort Study: influences of complex environmental exposures on maternal and child health in Suriname |
| title_full_unstemmed | Caribbean Consortium for Research in Environmental and Occupational Health (CCREOH) Cohort Study: influences of complex environmental exposures on maternal and child health in Suriname |
| title_short | Caribbean Consortium for Research in Environmental and Occupational Health (CCREOH) Cohort Study: influences of complex environmental exposures on maternal and child health in Suriname |
| title_sort | caribbean consortium for research in environmental and occupational health ccreoh cohort study influences of complex environmental exposures on maternal and child health in suriname |
| url | https://bmjopen.bmj.com/content/10/9/e034702.full |
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