Bi-Hormonal Endocrine Cell Presence Within the Islets of Langerhans of the Human Pancreas Throughout Life

Bi-Hormonal Endocrine Cell Presence Within the Islets of Langerhans of the Human Pancreas Throughout Life

Bi-hormonal islet endocrine cells have been proposed to represent an intermediate state of cellular transdifferentiation, enabling an increase in beta-cell mass in response to severe metabolic stress. Beta-cell plasticity and regenerative capacity are thought to decrease with age. We investigated th...

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Bibliographic Details
Main Authors: Jiwon Hahm, Dawn Kumar, Juan Andres Fernandez Andrade, Edith Arany, David J. Hill
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Cells
Subjects:
human
pancreas
islets of Langerhans
bi-hormonal cells
insulin
lifespan
Online Access:https://www.mdpi.com/2073-4409/14/1/34
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