Capturing the Heterogeneity of the PDAC Tumor Microenvironment: Novel Triple Co-Culture Spheroids for Drug Screening and Angiogenic Evaluation

Capturing the Heterogeneity of the PDAC Tumor Microenvironment: Novel Triple Co-Culture Spheroids for Drug Screening and Angiogenic Evaluation

Pancreatic ductal adenocarcinoma (PDAC) presents significant treatment challenges due to its desmoplastic reaction, which impedes therapeutic effectiveness, highlighting the need for advanced vitro models to better mimic the complex tumor environment. The current three-dimensional co-culture models...

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Bibliographic Details
Main Authors: Ruben Verloy, Angela Privat-Maldonado, Jonas Van Audenaerde, Sophie Rovers, Hannah Zaryouh, Jorrit De Waele, Delphine Quatannens, Dieter Peeters, Geert Roeyen, Christophe Deben, Evelien Smits, Annemie Bogaerts
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Cells
Subjects:
pancreatic ductal adenocarcinoma
triple co-culture spheroids
tumor microenvironment
drug resistance
heterogeneity
angiogenesis
Online Access:https://www.mdpi.com/2073-4409/14/6/450
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