Identification of ANXA1 as a Novel Upstream Negative Regulator of Notch1 Function in AML

Identification of ANXA1 as a Novel Upstream Negative Regulator of Notch1 Function in AML

Abstract Abnormal Notch1 expression has an important role in tumorigenesis. However, upstream control mechanisms for Notch1 are still insufficiently understood. Acute myeloid leukemia (AML) is one of the most common and lethal blood malignancies with limited possibilities for treatment. Thus, new th...

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Main Authors: Gang Shao, Xi Wang, Yiting Zheng, Junjie Ma, Lei Wang, Zhibin Yan, Zeyu Sun, Shuyuan Zhang, Hongzhang Wu, Yudie Lv, Hemiao Huang, Jianhu Li, Tianyi Zhu, Bing Yang, Nanxi Wang, Tao Chen, Xuancheng Guo, Yuanting Jin, Jian Kang, Huafeng Wang, Yihai Cao, Caiyun Fu
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Advanced Science
Subjects:
acute myeloid leukemia
annexin a1
anxa1‐notch1‐p15 signal axis
notch1
peptide inhibitors
protein‐protein interaction
Online Access:https://doi.org/10.1002/advs.202409726
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