Forearm elevation impairs local static handgrip endurance likely through reduction in vascular conductance and perfusion pressure: revisiting Rohmert’s curve
Abstract Maximal isometric contraction time (MICT) is critical for most motor tasks and depends on skeletal muscle blood flow at < 40% of maximal voluntary strength (MVC). Whether limb work positions associated with reduced perfusion pressure and facilitated vessel compression affect MICT is larg...
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Nature Portfolio
2025-01-01
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| author | L. Heinzl S. Risse H. Schwarzbach O. Hildebrandt U. Koehler A. M. Koenig A. H. Mahnken R. Kinscherf W. Hildebrandt |
| author_facet | L. Heinzl S. Risse H. Schwarzbach O. Hildebrandt U. Koehler A. M. Koenig A. H. Mahnken R. Kinscherf W. Hildebrandt |
| author_sort | L. Heinzl |
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| description | Abstract Maximal isometric contraction time (MICT) is critical for most motor tasks and depends on skeletal muscle blood flow at < 40% of maximal voluntary strength (MVC). Whether limb work positions associated with reduced perfusion pressure and facilitated vessel compression affect MICT is largely unknown. In 14 healthy young men we therefore assessed bilateral handgrip MICT at 15, 20, 30, 40, and 70% of MVC in horizontal forearm positions of 0.0, + 27.5 or − 27.5 cm relative to heart level. Forearm blood flow (FBF, venous occlusion plethysmography) and brachial blood pressure were measured repetitively. MICT at 15% MVC was significantly shorter by 66.3 and 86.2 s with forearm position + 27.5 cm (389.6 ± 23.3 s) as compared to 0.0 cm (455.9 ± 34.1 s) and − 27.5 cm (475.8 ± 35.0 s) while MICT at 20–70% MVC was unaffected. Peak FBF at 15% MVC was significantly lower in position + 27.5 cm (11.11 ± 0.92 ml/min/100 ml) compared to 0.0 cm (15.55 ± 0.91 ml/min/100 ml) or − 27.5 cm (14.21 ± 0.59 ml/min/100 ml) and vascular resistance significantly higher in position + 27.5 vs 0.0 or − 27.5 cm. Working position above, but not below heart level may limit MICT at 15% MVC possibly through blood flow reduction arising from increased vascular resistance beside reduced perfusion pressure. Local isometric endurance warrants (re)evaluation regarding hydrostatic/gravitational or other hemodynamic limitations. |
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| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
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| spelling | doaj-art-d9e0767b9d8844e89d8731260ff134c02025-01-12T12:17:14ZengNature PortfolioScientific Reports2045-23222025-01-0115111510.1038/s41598-024-83939-7Forearm elevation impairs local static handgrip endurance likely through reduction in vascular conductance and perfusion pressure: revisiting Rohmert’s curveL. Heinzl0S. Risse1H. Schwarzbach2O. Hildebrandt3U. Koehler4A. M. Koenig5A. H. Mahnken6R. Kinscherf7W. Hildebrandt8Institute for Anatomy und Cell Biology, Department of Medical Cell Biology, Philipps-Universität MarburgInstitute for Anatomy und Cell Biology, Department of Medical Cell Biology, Philipps-Universität MarburgInstitute for Anatomy und Cell Biology, Department of Medical Cell Biology, Philipps-Universität MarburgDepartment of Sleep Medicine, Division of Pneumology, Internal Medicine, University Hospital of Marburg, Philipps-Universität MarburgDepartment of Sleep Medicine, Division of Pneumology, Internal Medicine, University Hospital of Marburg, Philipps-Universität MarburgDepartment of Diagnostic and Interventional Radiology, University Hospital of Marburg, Philipps-UniversityDepartment of Diagnostic and Interventional Radiology, University Hospital of Marburg, Philipps-UniversityInstitute for Anatomy und Cell Biology, Department of Medical Cell Biology, Philipps-Universität MarburgInstitute for Anatomy und Cell Biology, Department of Medical Cell Biology, Philipps-Universität MarburgAbstract Maximal isometric contraction time (MICT) is critical for most motor tasks and depends on skeletal muscle blood flow at < 40% of maximal voluntary strength (MVC). Whether limb work positions associated with reduced perfusion pressure and facilitated vessel compression affect MICT is largely unknown. In 14 healthy young men we therefore assessed bilateral handgrip MICT at 15, 20, 30, 40, and 70% of MVC in horizontal forearm positions of 0.0, + 27.5 or − 27.5 cm relative to heart level. Forearm blood flow (FBF, venous occlusion plethysmography) and brachial blood pressure were measured repetitively. MICT at 15% MVC was significantly shorter by 66.3 and 86.2 s with forearm position + 27.5 cm (389.6 ± 23.3 s) as compared to 0.0 cm (455.9 ± 34.1 s) and − 27.5 cm (475.8 ± 35.0 s) while MICT at 20–70% MVC was unaffected. Peak FBF at 15% MVC was significantly lower in position + 27.5 cm (11.11 ± 0.92 ml/min/100 ml) compared to 0.0 cm (15.55 ± 0.91 ml/min/100 ml) or − 27.5 cm (14.21 ± 0.59 ml/min/100 ml) and vascular resistance significantly higher in position + 27.5 vs 0.0 or − 27.5 cm. Working position above, but not below heart level may limit MICT at 15% MVC possibly through blood flow reduction arising from increased vascular resistance beside reduced perfusion pressure. Local isometric endurance warrants (re)evaluation regarding hydrostatic/gravitational or other hemodynamic limitations.https://doi.org/10.1038/s41598-024-83939-7Skeletal muscleStatic exerciseFatigueBlood flowGravitationHydrostatic pressure |
| spellingShingle | L. Heinzl S. Risse H. Schwarzbach O. Hildebrandt U. Koehler A. M. Koenig A. H. Mahnken R. Kinscherf W. Hildebrandt Forearm elevation impairs local static handgrip endurance likely through reduction in vascular conductance and perfusion pressure: revisiting Rohmert’s curve Scientific Reports Skeletal muscle Static exercise Fatigue Blood flow Gravitation Hydrostatic pressure |
| title | Forearm elevation impairs local static handgrip endurance likely through reduction in vascular conductance and perfusion pressure: revisiting Rohmert’s curve |
| title_full | Forearm elevation impairs local static handgrip endurance likely through reduction in vascular conductance and perfusion pressure: revisiting Rohmert’s curve |
| title_fullStr | Forearm elevation impairs local static handgrip endurance likely through reduction in vascular conductance and perfusion pressure: revisiting Rohmert’s curve |
| title_full_unstemmed | Forearm elevation impairs local static handgrip endurance likely through reduction in vascular conductance and perfusion pressure: revisiting Rohmert’s curve |
| title_short | Forearm elevation impairs local static handgrip endurance likely through reduction in vascular conductance and perfusion pressure: revisiting Rohmert’s curve |
| title_sort | forearm elevation impairs local static handgrip endurance likely through reduction in vascular conductance and perfusion pressure revisiting rohmert s curve |
| topic | Skeletal muscle Static exercise Fatigue Blood flow Gravitation Hydrostatic pressure |
| url | https://doi.org/10.1038/s41598-024-83939-7 |
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