Polyomaviruses and the risk of oral cancer: a systematic review and meta-analysis
Abstract Objectives Oral cancer (OC) is the most common malignant tumor of the head and neck (HN) and ranks 16th among the most frequently diagnosed cancers worldwide. A systematic review and meta-analysis aimed to provide an evidence-based analysis of the relationship between polyomaviruses and ora...
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| Format: | Article |
| Language: | English |
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BMC
2024-12-01
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| Series: | BMC Oral Health |
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| Online Access: | https://doi.org/10.1186/s12903-024-05330-2 |
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| _version_ | 1846112079082160128 |
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| author | Tahoora Mousavi Fatemeh Shokoohy Mahmood Moosazadeh |
| author_facet | Tahoora Mousavi Fatemeh Shokoohy Mahmood Moosazadeh |
| author_sort | Tahoora Mousavi |
| collection | DOAJ |
| description | Abstract Objectives Oral cancer (OC) is the most common malignant tumor of the head and neck (HN) and ranks 16th among the most frequently diagnosed cancers worldwide. A systematic review and meta-analysis aimed to provide an evidence-based analysis of the relationship between polyomaviruses and oral cancer. Methods The global online databases was used to identify relevant studies published between January 2000 and September 2024. The quality of each article was assessed using the Newcastle-Ottawa Scale (NOS) checklist. Data analysis was performed using STATA Ver. 11 software, and the standard error was calculated using the binomial distribution formula. The heterogeneity of the study results was assessed using the I-square and Q index, while publication bias was examined using the Begg’s test. In addition, a random effects model was used to determine the risk difference (RD), and a forest plot diagram was used to present the results with 95% confidence intervals. The Trim and Fill test was applied to estimate publication bias, and sensitivity analysis was performed to assess the influence of individual studies on the overall estimate. Results Of the nine studies, the relationship between BK virus (BKV) and the Merkel cell polyomavirus (MCV) and oral cancer was investigated. In five primary studies, and by combining the results of these studies, the risk of oral cancer in MCV and BKV-positive individuals was significantly higher than in the negative groups by 13% (RD: 0.13, 95% CI: 0.00, 0.26) and 2% (RD: 0.02, 95% CI: -0.03, 0.07), respectively. In addition, the association between JC virus (JCV) and oral cancer was investigated in six primary studies. By combining the results of these studies, the risk of oral cancer in JCV-positive individuals was 1% higher than that in JCV-negative individuals (RD: 0.01, 95% CI: -0.02, 0.06). Discussion This meta-analysis showed that there was a significant association between MCV and oral cancer, and the risk of oral cancer in MCV- positive individuals was 13% higher than that in MCV- negative individuals. More preliminary studies are needed on the association between BKV and JCV and the risk of oral cancer. |
| format | Article |
| id | doaj-art-d9bc2b4bd47e4efc950f2d7f031bd56f |
| institution | Kabale University |
| issn | 1472-6831 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Oral Health |
| spelling | doaj-art-d9bc2b4bd47e4efc950f2d7f031bd56f2024-12-22T12:51:37ZengBMCBMC Oral Health1472-68312024-12-0124111010.1186/s12903-024-05330-2Polyomaviruses and the risk of oral cancer: a systematic review and meta-analysisTahoora Mousavi0Fatemeh Shokoohy1Mahmood Moosazadeh2Molecular and Cell Biology Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical SciencesNon-communicable Diseases Institute, Molecular and Cellular Biology Research Center, Mazandaran University of Medical SciencesGastrointestinal Cancer Research Center, Non-Communicable Diseases Institute, Mazandaran University of Medical SciencesAbstract Objectives Oral cancer (OC) is the most common malignant tumor of the head and neck (HN) and ranks 16th among the most frequently diagnosed cancers worldwide. A systematic review and meta-analysis aimed to provide an evidence-based analysis of the relationship between polyomaviruses and oral cancer. Methods The global online databases was used to identify relevant studies published between January 2000 and September 2024. The quality of each article was assessed using the Newcastle-Ottawa Scale (NOS) checklist. Data analysis was performed using STATA Ver. 11 software, and the standard error was calculated using the binomial distribution formula. The heterogeneity of the study results was assessed using the I-square and Q index, while publication bias was examined using the Begg’s test. In addition, a random effects model was used to determine the risk difference (RD), and a forest plot diagram was used to present the results with 95% confidence intervals. The Trim and Fill test was applied to estimate publication bias, and sensitivity analysis was performed to assess the influence of individual studies on the overall estimate. Results Of the nine studies, the relationship between BK virus (BKV) and the Merkel cell polyomavirus (MCV) and oral cancer was investigated. In five primary studies, and by combining the results of these studies, the risk of oral cancer in MCV and BKV-positive individuals was significantly higher than in the negative groups by 13% (RD: 0.13, 95% CI: 0.00, 0.26) and 2% (RD: 0.02, 95% CI: -0.03, 0.07), respectively. In addition, the association between JC virus (JCV) and oral cancer was investigated in six primary studies. By combining the results of these studies, the risk of oral cancer in JCV-positive individuals was 1% higher than that in JCV-negative individuals (RD: 0.01, 95% CI: -0.02, 0.06). Discussion This meta-analysis showed that there was a significant association between MCV and oral cancer, and the risk of oral cancer in MCV- positive individuals was 13% higher than that in MCV- negative individuals. More preliminary studies are needed on the association between BKV and JCV and the risk of oral cancer.https://doi.org/10.1186/s12903-024-05330-2PolyomavirusMerkel cell polyomavirusMouth NeoplasmsBK Virusand JC VirusSimian virus 40 |
| spellingShingle | Tahoora Mousavi Fatemeh Shokoohy Mahmood Moosazadeh Polyomaviruses and the risk of oral cancer: a systematic review and meta-analysis BMC Oral Health Polyomavirus Merkel cell polyomavirus Mouth Neoplasms BK Virus and JC Virus Simian virus 40 |
| title | Polyomaviruses and the risk of oral cancer: a systematic review and meta-analysis |
| title_full | Polyomaviruses and the risk of oral cancer: a systematic review and meta-analysis |
| title_fullStr | Polyomaviruses and the risk of oral cancer: a systematic review and meta-analysis |
| title_full_unstemmed | Polyomaviruses and the risk of oral cancer: a systematic review and meta-analysis |
| title_short | Polyomaviruses and the risk of oral cancer: a systematic review and meta-analysis |
| title_sort | polyomaviruses and the risk of oral cancer a systematic review and meta analysis |
| topic | Polyomavirus Merkel cell polyomavirus Mouth Neoplasms BK Virus and JC Virus Simian virus 40 |
| url | https://doi.org/10.1186/s12903-024-05330-2 |
| work_keys_str_mv | AT tahooramousavi polyomavirusesandtheriskoforalcancerasystematicreviewandmetaanalysis AT fatemehshokoohy polyomavirusesandtheriskoforalcancerasystematicreviewandmetaanalysis AT mahmoodmoosazadeh polyomavirusesandtheriskoforalcancerasystematicreviewandmetaanalysis |