The real-world association between digital markers of circadian disruption and mental health risks
Abstract While circadian disruption is recognized as a potential driver of depression, its real-world impact is poorly understood. A critical step to addressing this is the noninvasive collection of physiological time-series data outside laboratory settings in large populations. Digital tools offer...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-12-01
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| Series: | npj Digital Medicine |
| Online Access: | https://doi.org/10.1038/s41746-024-01348-6 |
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| author | Minki P. Lee Dae Wook Kim Yu Fang Ruby Kim Amy S. B. Bohnert Srijan Sen Daniel B. Forger |
| author_facet | Minki P. Lee Dae Wook Kim Yu Fang Ruby Kim Amy S. B. Bohnert Srijan Sen Daniel B. Forger |
| author_sort | Minki P. Lee |
| collection | DOAJ |
| description | Abstract While circadian disruption is recognized as a potential driver of depression, its real-world impact is poorly understood. A critical step to addressing this is the noninvasive collection of physiological time-series data outside laboratory settings in large populations. Digital tools offer promise in this endeavor. Here, using wearable data, we first quantify the degrees of circadian disruption, both between different internal rhythms and between each internal rhythm and the sleep-wake cycle. Our analysis, based on over 50,000 days of data from over 800 first-year training physicians, reveals bidirectional links between digital markers of circadian disruption and mood both before and after they began shift work, while accounting for confounders such as demographic and geographic variables. We further validate this by finding clinically relevant changes in the 9-item Patient Health Questionnaire score. Our findings validate a scalable digital measure of circadian disruption that could serve as a marker for psychiatric intervention. |
| format | Article |
| id | doaj-art-d9b144db3c824dc18ba4b2fe8ae91d25 |
| institution | Kabale University |
| issn | 2398-6352 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Digital Medicine |
| spelling | doaj-art-d9b144db3c824dc18ba4b2fe8ae91d252024-12-08T12:46:49ZengNature Portfolionpj Digital Medicine2398-63522024-12-017111510.1038/s41746-024-01348-6The real-world association between digital markers of circadian disruption and mental health risksMinki P. Lee0Dae Wook Kim1Yu Fang2Ruby Kim3Amy S. B. Bohnert4Srijan Sen5Daniel B. Forger6Department of Mathematics, University of MichiganDepartment of Mathematics, University of MichiganMichigan Neuroscience Institute, University of MichiganDepartment of Mathematics, University of MichiganDepartment of Psychiatry, University of MichiganMichigan Neuroscience Institute, University of MichiganDepartment of Mathematics, University of MichiganAbstract While circadian disruption is recognized as a potential driver of depression, its real-world impact is poorly understood. A critical step to addressing this is the noninvasive collection of physiological time-series data outside laboratory settings in large populations. Digital tools offer promise in this endeavor. Here, using wearable data, we first quantify the degrees of circadian disruption, both between different internal rhythms and between each internal rhythm and the sleep-wake cycle. Our analysis, based on over 50,000 days of data from over 800 first-year training physicians, reveals bidirectional links between digital markers of circadian disruption and mood both before and after they began shift work, while accounting for confounders such as demographic and geographic variables. We further validate this by finding clinically relevant changes in the 9-item Patient Health Questionnaire score. Our findings validate a scalable digital measure of circadian disruption that could serve as a marker for psychiatric intervention.https://doi.org/10.1038/s41746-024-01348-6 |
| spellingShingle | Minki P. Lee Dae Wook Kim Yu Fang Ruby Kim Amy S. B. Bohnert Srijan Sen Daniel B. Forger The real-world association between digital markers of circadian disruption and mental health risks npj Digital Medicine |
| title | The real-world association between digital markers of circadian disruption and mental health risks |
| title_full | The real-world association between digital markers of circadian disruption and mental health risks |
| title_fullStr | The real-world association between digital markers of circadian disruption and mental health risks |
| title_full_unstemmed | The real-world association between digital markers of circadian disruption and mental health risks |
| title_short | The real-world association between digital markers of circadian disruption and mental health risks |
| title_sort | real world association between digital markers of circadian disruption and mental health risks |
| url | https://doi.org/10.1038/s41746-024-01348-6 |
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