Primary liposarcoma of the uterus with MDM2 negative
Liposarcoma is one of the most common soft-tissue sarcomas that originates from adipose tissue. Primary uterine liposarcoma is extremely rare. With the MDM2, negative is even rarer. We report a 37-year-old woman presented with lower abdominal discomfort and increase in vaginal secretions for more th...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Indian Journal of Pathology and Microbiology |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/ijpm.ijpm_263_23 |
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| _version_ | 1841550041095864320 |
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| author | Shufei Wei Lushun Zhang Yongliang Han Liangliang Wang |
| author_facet | Shufei Wei Lushun Zhang Yongliang Han Liangliang Wang |
| author_sort | Shufei Wei |
| collection | DOAJ |
| description | Liposarcoma is one of the most common soft-tissue sarcomas that originates from adipose tissue. Primary uterine liposarcoma is extremely rare. With the MDM2, negative is even rarer. We report a 37-year-old woman presented with lower abdominal discomfort and increase in vaginal secretions for more than 2 months. The ultrasonography revealed a hypoechoic mass sized 81 × 73 × 67 mm in the right adnexal area. Histopathologically, the neoplasm was mainly composed of mature adipose tissue, a small number of scattered lipoblasts, and the spindle cell which with mild atypia. Immunohistochemistry showed that the tumor cells were positive for CDK4 but negative for MDM2, and FISH analysis showed no MDM2 amplification. The patient only underwent tumor excision and is currently doing well. |
| format | Article |
| id | doaj-art-d9a3bd9705574b6baa7beac09aca0c1f |
| institution | Kabale University |
| issn | 0377-4929 0974-5130 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj-art-d9a3bd9705574b6baa7beac09aca0c1f2025-01-10T10:27:38ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49290974-51302024-12-0167490791010.4103/ijpm.ijpm_263_23Primary liposarcoma of the uterus with MDM2 negativeShufei WeiLushun ZhangYongliang HanLiangliang WangLiposarcoma is one of the most common soft-tissue sarcomas that originates from adipose tissue. Primary uterine liposarcoma is extremely rare. With the MDM2, negative is even rarer. We report a 37-year-old woman presented with lower abdominal discomfort and increase in vaginal secretions for more than 2 months. The ultrasonography revealed a hypoechoic mass sized 81 × 73 × 67 mm in the right adnexal area. Histopathologically, the neoplasm was mainly composed of mature adipose tissue, a small number of scattered lipoblasts, and the spindle cell which with mild atypia. Immunohistochemistry showed that the tumor cells were positive for CDK4 but negative for MDM2, and FISH analysis showed no MDM2 amplification. The patient only underwent tumor excision and is currently doing well.https://journals.lww.com/10.4103/ijpm.ijpm_263_23liposarcomamdm2uterine |
| spellingShingle | Shufei Wei Lushun Zhang Yongliang Han Liangliang Wang Primary liposarcoma of the uterus with MDM2 negative Indian Journal of Pathology and Microbiology liposarcoma mdm2 uterine |
| title | Primary liposarcoma of the uterus with MDM2 negative |
| title_full | Primary liposarcoma of the uterus with MDM2 negative |
| title_fullStr | Primary liposarcoma of the uterus with MDM2 negative |
| title_full_unstemmed | Primary liposarcoma of the uterus with MDM2 negative |
| title_short | Primary liposarcoma of the uterus with MDM2 negative |
| title_sort | primary liposarcoma of the uterus with mdm2 negative |
| topic | liposarcoma mdm2 uterine |
| url | https://journals.lww.com/10.4103/ijpm.ijpm_263_23 |
| work_keys_str_mv | AT shufeiwei primaryliposarcomaoftheuteruswithmdm2negative AT lushunzhang primaryliposarcomaoftheuteruswithmdm2negative AT yonglianghan primaryliposarcomaoftheuteruswithmdm2negative AT liangliangwang primaryliposarcomaoftheuteruswithmdm2negative |