Origin and cross-species transmission of bat coronaviruses in China
Abstract Bats are presumed reservoirs of diverse coronaviruses (CoVs) including progenitors of Severe Acute Respiratory Syndrome (SARS)-CoV and SARS-CoV-2, the causative agent of COVID-19. However, the evolution and diversification of these coronaviruses remains poorly understood. Here we use a Baye...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-12-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-55384-7 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846112446498996224 |
|---|---|
| author | Alice Latinne Ben Hu Kevin J. Olival Guangjian Zhu Li-Biao Zhang Hongying Li Aleksei A. Chmura Hume E. Field Carlos Zambrana-Torrelio Jonathan H. Epstein Bei Li Wei Zhang Lin-Fa Wang Zheng-Li Shi Peter Daszak |
| author_facet | Alice Latinne Ben Hu Kevin J. Olival Guangjian Zhu Li-Biao Zhang Hongying Li Aleksei A. Chmura Hume E. Field Carlos Zambrana-Torrelio Jonathan H. Epstein Bei Li Wei Zhang Lin-Fa Wang Zheng-Li Shi Peter Daszak |
| author_sort | Alice Latinne |
| collection | DOAJ |
| description | Abstract Bats are presumed reservoirs of diverse coronaviruses (CoVs) including progenitors of Severe Acute Respiratory Syndrome (SARS)-CoV and SARS-CoV-2, the causative agent of COVID-19. However, the evolution and diversification of these coronaviruses remains poorly understood. Here we use a Bayesian statistical framework and a large sequence data set from bat-CoVs (including 589 novel CoV sequences) in China to study their macroevolution, cross-species transmission and dispersal. We find that host-switching occurs more frequently and across more distantly related host taxa in alpha- than beta-CoVs, and is more highly constrained by phylogenetic distance for beta-CoVs. We show that inter-family and -genus switching is most common in Rhinolophidae and the genus Rhinolophus. Our analyses identify the host taxa and geographic regions that define hotspots of CoV evolutionary diversity in China that could help target bat-CoV discovery for proactive zoonotic disease surveillance. Finally, we present a phylogenetic analysis suggesting a likely origin for SARS-CoV-2 in Rhinolophus spp. bats. |
| format | Article |
| id | doaj-art-d9a268ffde4941cf8541dbb7f36836b4 |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-d9a268ffde4941cf8541dbb7f36836b42024-12-22T12:36:05ZengNature PortfolioNature Communications2041-17232024-12-0115111610.1038/s41467-024-55384-7Origin and cross-species transmission of bat coronaviruses in ChinaAlice Latinne0Ben Hu1Kevin J. Olival2Guangjian Zhu3Li-Biao Zhang4Hongying Li5Aleksei A. Chmura6Hume E. Field7Carlos Zambrana-Torrelio8Jonathan H. Epstein9Bei Li10Wei Zhang11Lin-Fa Wang12Zheng-Li Shi13Peter Daszak14EcoHealth AllianceWuhan Institute of Virology, Chinese Academy of SciencesEcoHealth AllianceEcoHealth AllianceGuangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Institute of Zoology, Guangdong Academy of SciencesEcoHealth AllianceEcoHealth AllianceEcoHealth AllianceEcoHealth AllianceEcoHealth AllianceWuhan Institute of Virology, Chinese Academy of SciencesWuhan Institute of Virology, Chinese Academy of SciencesProgramme in Emerging Infectious Disease, Duke-NUS Medical SchoolWuhan Institute of Virology, Chinese Academy of SciencesEcoHealth AllianceAbstract Bats are presumed reservoirs of diverse coronaviruses (CoVs) including progenitors of Severe Acute Respiratory Syndrome (SARS)-CoV and SARS-CoV-2, the causative agent of COVID-19. However, the evolution and diversification of these coronaviruses remains poorly understood. Here we use a Bayesian statistical framework and a large sequence data set from bat-CoVs (including 589 novel CoV sequences) in China to study their macroevolution, cross-species transmission and dispersal. We find that host-switching occurs more frequently and across more distantly related host taxa in alpha- than beta-CoVs, and is more highly constrained by phylogenetic distance for beta-CoVs. We show that inter-family and -genus switching is most common in Rhinolophidae and the genus Rhinolophus. Our analyses identify the host taxa and geographic regions that define hotspots of CoV evolutionary diversity in China that could help target bat-CoV discovery for proactive zoonotic disease surveillance. Finally, we present a phylogenetic analysis suggesting a likely origin for SARS-CoV-2 in Rhinolophus spp. bats.https://doi.org/10.1038/s41467-024-55384-7 |
| spellingShingle | Alice Latinne Ben Hu Kevin J. Olival Guangjian Zhu Li-Biao Zhang Hongying Li Aleksei A. Chmura Hume E. Field Carlos Zambrana-Torrelio Jonathan H. Epstein Bei Li Wei Zhang Lin-Fa Wang Zheng-Li Shi Peter Daszak Origin and cross-species transmission of bat coronaviruses in China Nature Communications |
| title | Origin and cross-species transmission of bat coronaviruses in China |
| title_full | Origin and cross-species transmission of bat coronaviruses in China |
| title_fullStr | Origin and cross-species transmission of bat coronaviruses in China |
| title_full_unstemmed | Origin and cross-species transmission of bat coronaviruses in China |
| title_short | Origin and cross-species transmission of bat coronaviruses in China |
| title_sort | origin and cross species transmission of bat coronaviruses in china |
| url | https://doi.org/10.1038/s41467-024-55384-7 |
| work_keys_str_mv | AT alicelatinne originandcrossspeciestransmissionofbatcoronavirusesinchina AT benhu originandcrossspeciestransmissionofbatcoronavirusesinchina AT kevinjolival originandcrossspeciestransmissionofbatcoronavirusesinchina AT guangjianzhu originandcrossspeciestransmissionofbatcoronavirusesinchina AT libiaozhang originandcrossspeciestransmissionofbatcoronavirusesinchina AT hongyingli originandcrossspeciestransmissionofbatcoronavirusesinchina AT alekseiachmura originandcrossspeciestransmissionofbatcoronavirusesinchina AT humeefield originandcrossspeciestransmissionofbatcoronavirusesinchina AT carloszambranatorrelio originandcrossspeciestransmissionofbatcoronavirusesinchina AT jonathanhepstein originandcrossspeciestransmissionofbatcoronavirusesinchina AT beili originandcrossspeciestransmissionofbatcoronavirusesinchina AT weizhang originandcrossspeciestransmissionofbatcoronavirusesinchina AT linfawang originandcrossspeciestransmissionofbatcoronavirusesinchina AT zhenglishi originandcrossspeciestransmissionofbatcoronavirusesinchina AT peterdaszak originandcrossspeciestransmissionofbatcoronavirusesinchina |