The characteristic expression of circulating MicroRNAs in osteoporosis: a systematic review and meta-analysis
ObjectiveTo evaluate the characteristics of the circulating microRNA expression profiles in patients with osteoporosis.MethodsA systematic literature search was performed using the Web of Science, PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), VIP, and WANFANG data...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1481649/full |
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| author | Jie Gao Xiuzhen Zhang Jing Ding Houli Zhang Xu Zhang Juan Jiang Wenwen Chen |
| author_facet | Jie Gao Xiuzhen Zhang Jing Ding Houli Zhang Xu Zhang Juan Jiang Wenwen Chen |
| author_sort | Jie Gao |
| collection | DOAJ |
| description | ObjectiveTo evaluate the characteristics of the circulating microRNA expression profiles in patients with osteoporosis.MethodsA systematic literature search was performed using the Web of Science, PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), VIP, and WANFANG databases from inception until 1 March 2024. The search strategy employed keywords, encompassing “osteoporosis”, “bone loss”, or “osteopenia” and “miRNA” or “microRNA”. The Newcastle-Ottawa Scale (NOS) quality assessment scale was used to evaluate the methodological quality. Heterogeneity tests and statistical analyses of all data were performed by Stata 16.0. The differences in microRNA levels between groups were illustrated by the weighted mean difference (WMD) and 95% confidence interval (95% CI).ResultsA total of 27 studies were included and analyzed in the meta-analysis, with 2,263 participants. The results showed that miR-21-5p (WMD 0.88, 95% CI: 0.22 to 1.55), miR-125b-5p (WMD 6.63, 95% CI: 0.19 to 13.08), miR-483-5p(WMD 6.43, 95% CI: 3.26 to 9.61), miR-133a (WMD 1.43, 95% CI: 1.39 to 1.47), miR-422a (WMD 1, 95% CI: 0.28 to 1.72), and miR-214-3p (WMD 2.03, 95% CI: 0.14 to 3.92) were significantly upregulated, and miR-497-5p (WMD -0.57, 95% CI: -0.98 to -0.17) was significantly downregulated.ConclusionmiR-21-5p, miR-125b-5p, miR-483-5p, miR-133a, miR-497-5p, miR-422a, and miR-214-3p might serve as potential diagnostic biomarkers for osteoporosis. In the future, integrating these miRNAs to build a diagnostic model might be a promising diagnosis strategy for osteoporosis.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42023481209. |
| format | Article |
| id | doaj-art-d9a0674de064496a9b136abcf1c2e0e2 |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-d9a0674de064496a9b136abcf1c2e0e22024-12-16T04:18:33ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-12-011510.3389/fendo.2024.14816491481649The characteristic expression of circulating MicroRNAs in osteoporosis: a systematic review and meta-analysisJie Gao0Xiuzhen Zhang1Jing Ding2Houli Zhang3Xu Zhang4Juan Jiang5Wenwen Chen6Department of Pharmacy, the Second Affiliated Hospital of Shandong First Medical University, Tai’an, ChinaDepartment of Pharmacy, the Second Affiliated Hospital of Shandong First Medical University, Tai’an, ChinaDepartment of Pharmacy, the Second Affiliated Hospital of Shandong First Medical University, Tai’an, ChinaDepartment of Pharmacy, the Second Affiliated Hospital of Shandong First Medical University, Tai’an, ChinaDepartment of Pharmacy, the Second Affiliated Hospital of Shandong First Medical University, Tai’an, ChinaDepartment of Stomatology, the Second Affiliated Hospital of Shandong First Medical University, Tai’an, ChinaDepartment of Pharmacy, the Second Affiliated Hospital of Shandong First Medical University, Tai’an, ChinaObjectiveTo evaluate the characteristics of the circulating microRNA expression profiles in patients with osteoporosis.MethodsA systematic literature search was performed using the Web of Science, PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), VIP, and WANFANG databases from inception until 1 March 2024. The search strategy employed keywords, encompassing “osteoporosis”, “bone loss”, or “osteopenia” and “miRNA” or “microRNA”. The Newcastle-Ottawa Scale (NOS) quality assessment scale was used to evaluate the methodological quality. Heterogeneity tests and statistical analyses of all data were performed by Stata 16.0. The differences in microRNA levels between groups were illustrated by the weighted mean difference (WMD) and 95% confidence interval (95% CI).ResultsA total of 27 studies were included and analyzed in the meta-analysis, with 2,263 participants. The results showed that miR-21-5p (WMD 0.88, 95% CI: 0.22 to 1.55), miR-125b-5p (WMD 6.63, 95% CI: 0.19 to 13.08), miR-483-5p(WMD 6.43, 95% CI: 3.26 to 9.61), miR-133a (WMD 1.43, 95% CI: 1.39 to 1.47), miR-422a (WMD 1, 95% CI: 0.28 to 1.72), and miR-214-3p (WMD 2.03, 95% CI: 0.14 to 3.92) were significantly upregulated, and miR-497-5p (WMD -0.57, 95% CI: -0.98 to -0.17) was significantly downregulated.ConclusionmiR-21-5p, miR-125b-5p, miR-483-5p, miR-133a, miR-497-5p, miR-422a, and miR-214-3p might serve as potential diagnostic biomarkers for osteoporosis. In the future, integrating these miRNAs to build a diagnostic model might be a promising diagnosis strategy for osteoporosis.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42023481209.https://www.frontiersin.org/articles/10.3389/fendo.2024.1481649/fullmicroRNAexpressiondiagnosisosteoporosismeta-analysis |
| spellingShingle | Jie Gao Xiuzhen Zhang Jing Ding Houli Zhang Xu Zhang Juan Jiang Wenwen Chen The characteristic expression of circulating MicroRNAs in osteoporosis: a systematic review and meta-analysis Frontiers in Endocrinology microRNA expression diagnosis osteoporosis meta-analysis |
| title | The characteristic expression of circulating MicroRNAs in osteoporosis: a systematic review and meta-analysis |
| title_full | The characteristic expression of circulating MicroRNAs in osteoporosis: a systematic review and meta-analysis |
| title_fullStr | The characteristic expression of circulating MicroRNAs in osteoporosis: a systematic review and meta-analysis |
| title_full_unstemmed | The characteristic expression of circulating MicroRNAs in osteoporosis: a systematic review and meta-analysis |
| title_short | The characteristic expression of circulating MicroRNAs in osteoporosis: a systematic review and meta-analysis |
| title_sort | characteristic expression of circulating micrornas in osteoporosis a systematic review and meta analysis |
| topic | microRNA expression diagnosis osteoporosis meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1481649/full |
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