GPX4 expression changes in proximal tubule cells highlight the role of ferroptosis in IgAN

GPX4 expression changes in proximal tubule cells highlight the role of ferroptosis in IgAN

Abstract As an important mechanism of renal injury, oxidative stress (OS) is inseparable from the occurrence of renal fibrosis and the rapid progression of renal failure. However, the contribution of OS to IgA nephropathy (IgAN), the primary driver of chronic kidney disease remains uncertain. To inv...

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Bibliographic Details
Main Authors: Jianbo Qing, Lijuan Zhang, Ru Fan, Huiwen Zhi, Changqun Li, Yaheng Li, Junnan Wu, Chongyang Han, Yafeng Li
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
IgA nephropathy
Proximal tubule cell
Tubulointerstitium
Oxidative stress
Ferroptosis
Online Access:https://doi.org/10.1038/s41598-025-87228-9
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