Epigenetic modification regulates the ligamentum flavum hypertrophy through miR-335-3p/SERPINE2/β-catenin signaling pathway

Epigenetic modification regulates the ligamentum flavum hypertrophy through miR-335-3p/SERPINE2/β-catenin signaling pathway

Abstract Background Epigenetic modifications have been proved to play important roles in the spinal degenerative diseases. As a type of noncoding RNA, the microRNA (miRNA) is a vital class of regulatory factor in the epigenetic modifications, while the role of miRNAs in the regulation of epigenetic...

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Bibliographic Details
Main Authors: Yongzhao Zhao, Shuai Jiang, Longting Chen, Qian Xiang, Jialiang Lin, Weishi Li
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Cellular & Molecular Biology Letters
Subjects:
Lumbar spinal stenosis
Ligamentum flavum hypertrophy
Fibrosis
Epigenetic modification
Online Access:https://doi.org/10.1186/s11658-024-00660-z
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