Effect of Antibiotic on Men with Raised Prostatic-Specific Antigen (4-10 ng/ml)
Background: The managing of raised Prostate-Specific Antigen (PSA) in a range of 4 to 10 ng/ml is still controversial among urologists. In addition to prostatic cancer, benign prostatic hyperplasia, and prostatitis is established to increase PSA. PSA reduction after antibiotic therapy might detect t...
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University of Anbar
2020-12-01
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| Series: | Al-Anbar Medical Journal |
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| Online Access: | https://amj.uoanbar.edu.iq/article_170952_55ed86b3168441e84a1e5f1806a1f804.pdf |
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| author | Abdulsattar J. Ali Thaker Thiab |
| author_facet | Abdulsattar J. Ali Thaker Thiab |
| author_sort | Abdulsattar J. Ali |
| collection | DOAJ |
| description | Background: The managing of raised Prostate-Specific Antigen (PSA) in a range of 4 to 10 ng/ml is still controversial among urologists. In addition to prostatic cancer, benign prostatic hyperplasia, and prostatitis is established to increase PSA. PSA reduction after antibiotic therapy might detect those patients in whom biopsy can be avoided or postponed. Objectives: To evaluate the effectiveness of a 6 weeks levofloxacin course on the serum total PSA level and PSA density (PSAD) in patients with PSA 4 -10 ng/ml and ordinary digital rectal examination and ultrasonography results. Materials and Methods: The study conducted at Al-Ramadi Teaching Hospital from February 2016 to December 2019. A total of 177 men with benign prostatic hyperplasia or lower urinary tract symptoms were with a normal digital rectal examination, chronic prostatitis (Expressed prostatic secretion was done before treatment), total PSA 4-10 ng/ml, and ultrasonography findings that did not reveal a hypoechoic lesion in the prostate will be included in this study. Serum PSA and PSAD were measured before, and after treatment with a 6 weeks course of levofloxacin. Results: The age of our 177 men was ranged from 40-80 years with a mean age of 56.52 years ± 7.253. The mean prostatic size was 49.5 ± 28.5 g (range, 23-150 g). In 89 (50.2%) patients of the 177 men, total PSA has normalized to less than 4 ng/ml after antibiotics treatment. In 56 patients of 89 men had a high level of PSAD. PSAD was normalized (less than 0.15 ng/ml/cm3) after treatment in 49 patients of the 56 patients. A significant reduction in total PSA and PSAD after treatment (p <0.05). |
| format | Article |
| id | doaj-art-d95516b9221d4e3691aed2f5b4b8e033 |
| institution | Kabale University |
| issn | 2706-6207 2664-3154 |
| language | English |
| publishDate | 2020-12-01 |
| publisher | University of Anbar |
| record_format | Article |
| series | Al-Anbar Medical Journal |
| spelling | doaj-art-d95516b9221d4e3691aed2f5b4b8e0332024-12-01T20:13:12ZengUniversity of AnbarAl-Anbar Medical Journal2706-62072664-31542020-12-01162313410.33091/amj.2020.170952170952Effect of Antibiotic on Men with Raised Prostatic-Specific Antigen (4-10 ng/ml)Abdulsattar J. Ali0Thaker Thiab1Department of Surgery (Urology), Al-Ramadi Teaching Hospital, Anbar Health Directorate, Ramadi, Anbar, IraDepartment of Surgery (General Surgery), Al-Ramadi Teaching Hospital, Anbar Health Directorate, Ramadi, Anbar, Iraq.Background: The managing of raised Prostate-Specific Antigen (PSA) in a range of 4 to 10 ng/ml is still controversial among urologists. In addition to prostatic cancer, benign prostatic hyperplasia, and prostatitis is established to increase PSA. PSA reduction after antibiotic therapy might detect those patients in whom biopsy can be avoided or postponed. Objectives: To evaluate the effectiveness of a 6 weeks levofloxacin course on the serum total PSA level and PSA density (PSAD) in patients with PSA 4 -10 ng/ml and ordinary digital rectal examination and ultrasonography results. Materials and Methods: The study conducted at Al-Ramadi Teaching Hospital from February 2016 to December 2019. A total of 177 men with benign prostatic hyperplasia or lower urinary tract symptoms were with a normal digital rectal examination, chronic prostatitis (Expressed prostatic secretion was done before treatment), total PSA 4-10 ng/ml, and ultrasonography findings that did not reveal a hypoechoic lesion in the prostate will be included in this study. Serum PSA and PSAD were measured before, and after treatment with a 6 weeks course of levofloxacin. Results: The age of our 177 men was ranged from 40-80 years with a mean age of 56.52 years ± 7.253. The mean prostatic size was 49.5 ± 28.5 g (range, 23-150 g). In 89 (50.2%) patients of the 177 men, total PSA has normalized to less than 4 ng/ml after antibiotics treatment. In 56 patients of 89 men had a high level of PSAD. PSAD was normalized (less than 0.15 ng/ml/cm3) after treatment in 49 patients of the 56 patients. A significant reduction in total PSA and PSAD after treatment (p <0.05). https://amj.uoanbar.edu.iq/article_170952_55ed86b3168441e84a1e5f1806a1f804.pdfprostate-specific antigenantibioticsprostate cancerprostatitis |
| spellingShingle | Abdulsattar J. Ali Thaker Thiab Effect of Antibiotic on Men with Raised Prostatic-Specific Antigen (4-10 ng/ml) Al-Anbar Medical Journal prostate-specific antigen antibiotics prostate cancer prostatitis |
| title | Effect of Antibiotic on Men with Raised Prostatic-Specific Antigen (4-10 ng/ml) |
| title_full | Effect of Antibiotic on Men with Raised Prostatic-Specific Antigen (4-10 ng/ml) |
| title_fullStr | Effect of Antibiotic on Men with Raised Prostatic-Specific Antigen (4-10 ng/ml) |
| title_full_unstemmed | Effect of Antibiotic on Men with Raised Prostatic-Specific Antigen (4-10 ng/ml) |
| title_short | Effect of Antibiotic on Men with Raised Prostatic-Specific Antigen (4-10 ng/ml) |
| title_sort | effect of antibiotic on men with raised prostatic specific antigen 4 10 ng ml |
| topic | prostate-specific antigen antibiotics prostate cancer prostatitis |
| url | https://amj.uoanbar.edu.iq/article_170952_55ed86b3168441e84a1e5f1806a1f804.pdf |
| work_keys_str_mv | AT abdulsattarjali effectofantibioticonmenwithraisedprostaticspecificantigen410ngml AT thakerthiab effectofantibioticonmenwithraisedprostaticspecificantigen410ngml |