EFFICACY AND SAFETY OF VASOACTIVE BETA-BLOCKERS IN ACUTE PHARMACOLOGICAL TEST IN HYPERTENSIVE PATIENTS OF DIFFERENT AGES
Aim. To evaluate a short-term efficacy and safety of nebivolol and carvedilol in hypertensive patients of different ages in acute pharmacological test (APT).Material and methods. 119 patients with arterial hypertension (HT) 2-3 degrees aged 33-89 y.o. were involved into the study. Patients were spli...
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Столичная издательская компания
2016-01-01
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| Series: | Рациональная фармакотерапия в кардиологии |
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| Online Access: | https://www.rpcardio.online/jour/article/view/716 |
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| author | O. V. Fedorishina A. A. Dzizinsky K. V. Protasov V. A. Protasova T. I. Kucherova E. G. Zakharova D. D. Baskhaeva T. S. Sukhoroslova O. V. Perkova |
| author_facet | O. V. Fedorishina A. A. Dzizinsky K. V. Protasov V. A. Protasova T. I. Kucherova E. G. Zakharova D. D. Baskhaeva T. S. Sukhoroslova O. V. Perkova |
| author_sort | O. V. Fedorishina |
| collection | DOAJ |
| description | Aim. To evaluate a short-term efficacy and safety of nebivolol and carvedilol in hypertensive patients of different ages in acute pharmacological test (APT).Material and methods. 119 patients with arterial hypertension (HT) 2-3 degrees aged 33-89 y.o. were involved into the study. Patients were split into 2 groups according to age: young and middle-aged patients (30-59 y.o.); elderly and senile patients (≥60 y.o.). All patients were randomized for carvedilol (12.5 mg once daily) or nebivolol (5 mg once daily) therapy after wash-out period (3-10 days). Ambulatory blood pressure monitoring (ABPM) was performed one day before and one day after first drug taking and ABPM indices were compared.Results. APT with carvedilol and nebivolol in patients of young and middle age showed significant antihypertensive effect on systolic (-6.9 and -6.0 mm Hg, resp.), diastolic (- 4.6 and -4.7 mm Hg, resp.) and pulse (-1.7 and -1.4 mm Hg, resp.) blood pressure (BP). In patients of elderly and senile age the first daily dose of nebivolol did not have influence on systolic and pulse BP (-2.73 and +0.50 mm Hg, resp., p>0.05), unlike carvedilol (-5.27 and -1.43 mm Hg, resp. p<0.05). Carvedilol and nebivolol increased of hypotension time index for diastolic BP in younger (7,6 and 7,7%, resp.) and elder (11 and 8,2% resp.) patients.Conclusion. Carvedilol in initial dose reduces systolic and pulse BP more significantly than nebivolol does in hypertensive elderly and senile patients. Increase of hypotension time index for diastolic BP revealed for both drugs can limit their use in patients with initially low diastolic BP. |
| format | Article |
| id | doaj-art-d93a78ac7cc74da1bfd9fad3fc277a6d |
| institution | Kabale University |
| issn | 1819-6446 2225-3653 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj-art-d93a78ac7cc74da1bfd9fad3fc277a6d2025-08-23T10:00:22ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532016-01-0155414510.20996/1819-6446-2009-5-5-41-45715EFFICACY AND SAFETY OF VASOACTIVE BETA-BLOCKERS IN ACUTE PHARMACOLOGICAL TEST IN HYPERTENSIVE PATIENTS OF DIFFERENT AGESO. V. Fedorishina0A. A. Dzizinsky1K. V. Protasov2V. A. Protasova3T. I. Kucherova4E. G. Zakharova5D. D. Baskhaeva6T. S. Sukhoroslova7O. V. Perkova8Irkutsk State Medical Institute for Postgraduate EducationIrkutsk State Medical Institute for Postgraduate EducationIrkutsk State Medical Institute for Postgraduate EducationAngarsk city hospital №1Angarsk city hospital №1Angarsk city hospital №1Angarsk city hospital №1Angarsk city hospital №1Angarsk city hospital №1Aim. To evaluate a short-term efficacy and safety of nebivolol and carvedilol in hypertensive patients of different ages in acute pharmacological test (APT).Material and methods. 119 patients with arterial hypertension (HT) 2-3 degrees aged 33-89 y.o. were involved into the study. Patients were split into 2 groups according to age: young and middle-aged patients (30-59 y.o.); elderly and senile patients (≥60 y.o.). All patients were randomized for carvedilol (12.5 mg once daily) or nebivolol (5 mg once daily) therapy after wash-out period (3-10 days). Ambulatory blood pressure monitoring (ABPM) was performed one day before and one day after first drug taking and ABPM indices were compared.Results. APT with carvedilol and nebivolol in patients of young and middle age showed significant antihypertensive effect on systolic (-6.9 and -6.0 mm Hg, resp.), diastolic (- 4.6 and -4.7 mm Hg, resp.) and pulse (-1.7 and -1.4 mm Hg, resp.) blood pressure (BP). In patients of elderly and senile age the first daily dose of nebivolol did not have influence on systolic and pulse BP (-2.73 and +0.50 mm Hg, resp., p>0.05), unlike carvedilol (-5.27 and -1.43 mm Hg, resp. p<0.05). Carvedilol and nebivolol increased of hypotension time index for diastolic BP in younger (7,6 and 7,7%, resp.) and elder (11 and 8,2% resp.) patients.Conclusion. Carvedilol in initial dose reduces systolic and pulse BP more significantly than nebivolol does in hypertensive elderly and senile patients. Increase of hypotension time index for diastolic BP revealed for both drugs can limit their use in patients with initially low diastolic BP.https://www.rpcardio.online/jour/article/view/716arterial hypertensioncarvedilolnebivololambulatory blood pressure monitoringacute pharmacological test |
| spellingShingle | O. V. Fedorishina A. A. Dzizinsky K. V. Protasov V. A. Protasova T. I. Kucherova E. G. Zakharova D. D. Baskhaeva T. S. Sukhoroslova O. V. Perkova EFFICACY AND SAFETY OF VASOACTIVE BETA-BLOCKERS IN ACUTE PHARMACOLOGICAL TEST IN HYPERTENSIVE PATIENTS OF DIFFERENT AGES Рациональная фармакотерапия в кардиологии arterial hypertension carvedilol nebivolol ambulatory blood pressure monitoring acute pharmacological test |
| title | EFFICACY AND SAFETY OF VASOACTIVE BETA-BLOCKERS IN ACUTE PHARMACOLOGICAL TEST IN HYPERTENSIVE PATIENTS OF DIFFERENT AGES |
| title_full | EFFICACY AND SAFETY OF VASOACTIVE BETA-BLOCKERS IN ACUTE PHARMACOLOGICAL TEST IN HYPERTENSIVE PATIENTS OF DIFFERENT AGES |
| title_fullStr | EFFICACY AND SAFETY OF VASOACTIVE BETA-BLOCKERS IN ACUTE PHARMACOLOGICAL TEST IN HYPERTENSIVE PATIENTS OF DIFFERENT AGES |
| title_full_unstemmed | EFFICACY AND SAFETY OF VASOACTIVE BETA-BLOCKERS IN ACUTE PHARMACOLOGICAL TEST IN HYPERTENSIVE PATIENTS OF DIFFERENT AGES |
| title_short | EFFICACY AND SAFETY OF VASOACTIVE BETA-BLOCKERS IN ACUTE PHARMACOLOGICAL TEST IN HYPERTENSIVE PATIENTS OF DIFFERENT AGES |
| title_sort | efficacy and safety of vasoactive beta blockers in acute pharmacological test in hypertensive patients of different ages |
| topic | arterial hypertension carvedilol nebivolol ambulatory blood pressure monitoring acute pharmacological test |
| url | https://www.rpcardio.online/jour/article/view/716 |
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