Gene-vegetarianism interactions in calcium, estimated glomerular filtration rate, and testosterone identified in genome-wide analysis across 30 biomarkers.
We examined the associations of vegetarianism with metabolic biomarkers using traditional and genetic epidemiology. First, we addressed inconsistencies in self-reported vegetarianism among UK Biobank participants by utilizing data from two dietary surveys to find a cohort of strict European vegetari...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2024-07-01
|
| Series: | PLoS Genetics |
| Online Access: | https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1011288&type=printable |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849329573527814144 |
|---|---|
| author | Michael Francis Kenneth E Westerman Alisa K Manning Kaixiong Ye |
| author_facet | Michael Francis Kenneth E Westerman Alisa K Manning Kaixiong Ye |
| author_sort | Michael Francis |
| collection | DOAJ |
| description | We examined the associations of vegetarianism with metabolic biomarkers using traditional and genetic epidemiology. First, we addressed inconsistencies in self-reported vegetarianism among UK Biobank participants by utilizing data from two dietary surveys to find a cohort of strict European vegetarians (N = 2,312). Vegetarians were matched 1:4 with nonvegetarians for non-genetic association analyses, revealing significant effects of vegetarianism in 15 of 30 biomarkers. Cholesterol measures plus vitamin D were significantly lower in vegetarians, while triglycerides were higher. A genome-wide association study revealed no genome-wide significant (GWS; 5×10-8) associations with vegetarian behavior. We performed genome-wide gene-vegetarianism interaction analyses for the biomarkers, and detected a GWS interaction impacting calcium at rs72952628 (P = 4.47×10-8). rs72952628 is in MMAA, a B12 metabolic pathway gene; B12 has major deficiency potential in vegetarians. Gene-based interaction tests revealed two significant genes, RNF168 in testosterone (P = 1.45×10-6) and DOCK4 in estimated glomerular filtration rate (eGFR) (P = 6.76×10-7), which have previously been associated with testicular and renal traits, respectively. These nutrigenetic findings indicate genotype can modify the associations between vegetarianism and health outcomes. |
| format | Article |
| id | doaj-art-d9399f1fdfca40e5bb9f1b6d13f6ad81 |
| institution | Kabale University |
| issn | 1553-7390 1553-7404 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Genetics |
| spelling | doaj-art-d9399f1fdfca40e5bb9f1b6d13f6ad812025-08-20T03:47:13ZengPublic Library of Science (PLoS)PLoS Genetics1553-73901553-74042024-07-01207e101128810.1371/journal.pgen.1011288Gene-vegetarianism interactions in calcium, estimated glomerular filtration rate, and testosterone identified in genome-wide analysis across 30 biomarkers.Michael FrancisKenneth E WestermanAlisa K ManningKaixiong YeWe examined the associations of vegetarianism with metabolic biomarkers using traditional and genetic epidemiology. First, we addressed inconsistencies in self-reported vegetarianism among UK Biobank participants by utilizing data from two dietary surveys to find a cohort of strict European vegetarians (N = 2,312). Vegetarians were matched 1:4 with nonvegetarians for non-genetic association analyses, revealing significant effects of vegetarianism in 15 of 30 biomarkers. Cholesterol measures plus vitamin D were significantly lower in vegetarians, while triglycerides were higher. A genome-wide association study revealed no genome-wide significant (GWS; 5×10-8) associations with vegetarian behavior. We performed genome-wide gene-vegetarianism interaction analyses for the biomarkers, and detected a GWS interaction impacting calcium at rs72952628 (P = 4.47×10-8). rs72952628 is in MMAA, a B12 metabolic pathway gene; B12 has major deficiency potential in vegetarians. Gene-based interaction tests revealed two significant genes, RNF168 in testosterone (P = 1.45×10-6) and DOCK4 in estimated glomerular filtration rate (eGFR) (P = 6.76×10-7), which have previously been associated with testicular and renal traits, respectively. These nutrigenetic findings indicate genotype can modify the associations between vegetarianism and health outcomes.https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1011288&type=printable |
| spellingShingle | Michael Francis Kenneth E Westerman Alisa K Manning Kaixiong Ye Gene-vegetarianism interactions in calcium, estimated glomerular filtration rate, and testosterone identified in genome-wide analysis across 30 biomarkers. PLoS Genetics |
| title | Gene-vegetarianism interactions in calcium, estimated glomerular filtration rate, and testosterone identified in genome-wide analysis across 30 biomarkers. |
| title_full | Gene-vegetarianism interactions in calcium, estimated glomerular filtration rate, and testosterone identified in genome-wide analysis across 30 biomarkers. |
| title_fullStr | Gene-vegetarianism interactions in calcium, estimated glomerular filtration rate, and testosterone identified in genome-wide analysis across 30 biomarkers. |
| title_full_unstemmed | Gene-vegetarianism interactions in calcium, estimated glomerular filtration rate, and testosterone identified in genome-wide analysis across 30 biomarkers. |
| title_short | Gene-vegetarianism interactions in calcium, estimated glomerular filtration rate, and testosterone identified in genome-wide analysis across 30 biomarkers. |
| title_sort | gene vegetarianism interactions in calcium estimated glomerular filtration rate and testosterone identified in genome wide analysis across 30 biomarkers |
| url | https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1011288&type=printable |
| work_keys_str_mv | AT michaelfrancis genevegetarianisminteractionsincalciumestimatedglomerularfiltrationrateandtestosteroneidentifiedingenomewideanalysisacross30biomarkers AT kennethewesterman genevegetarianisminteractionsincalciumestimatedglomerularfiltrationrateandtestosteroneidentifiedingenomewideanalysisacross30biomarkers AT alisakmanning genevegetarianisminteractionsincalciumestimatedglomerularfiltrationrateandtestosteroneidentifiedingenomewideanalysisacross30biomarkers AT kaixiongye genevegetarianisminteractionsincalciumestimatedglomerularfiltrationrateandtestosteroneidentifiedingenomewideanalysisacross30biomarkers |