Comparative study of the anti-tumour effects of the imipridone, ONC201 and its fluorinated analogues on pancreatic cancer cell line

Comparative study of the anti-tumour effects of the imipridone, ONC201 and its fluorinated analogues on pancreatic cancer cell line

Abstract Pancreatic ductal adenocarcinoma has a high mortality rate, with a 5-year survival rate of ~ 12%. Therefore, developing new targeted therapies is urgently needed. ONC-201, a promising candidate, is currently undergoing clinical trials. The main objective of the present work is to investigat...

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Main Authors: Zsófia Szász, Angéla Takács, Márton Kalabay, Péter Bárány, Tamás Czuczi, Antal Csámpai, Eszter Lajkó, László Kőhidai
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Pancreas adenocarcinoma
Imipridone
Apoptosis
ONC201
Drug development
Tumour selectivity
Online Access:https://doi.org/10.1038/s41598-025-00070-x
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https://doi.org/10.1038/s41598-025-00070-x

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