Neuroimmune signaling mediates astrocytic nucleocytoplasmic disruptions and stress granule formation associated with TDP-43 pathology

Neuroimmune signaling mediates astrocytic nucleocytoplasmic disruptions and stress granule formation associated with TDP-43 pathology

Alterations in transactivating response region DNA-binding protein 43 (TDP-43) are prevalent in amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and other neurological disorders. TDP-43 influences neuronal functions and might also affect glial cells. However, specific intracellula...

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Bibliographic Details
Main Authors: Constance Zhou, Evelyn J. Hardin, Till S. Zimmer, Stephanie Jackvony, Daniel Barnett, Noopur Khobrekar, Elisa Giacomelli, Lorenz Studer, Adam L. Orr, Anna G. Orr
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Neurobiology of Disease
Subjects:
Neurodegeneration
TDP-43
Astrocytes
Nuclear pore
Neuroimmune signaling
Stress granules
Online Access:http://www.sciencedirect.com/science/article/pii/S096999612500155X
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