The oral-gut microbiome axis in breast cancer: from basic research to therapeutic applications
As a complicated and heterogeneous condition, breast cancer (BC) has posed a tremendous public health challenge across the world. Recent studies have uncovered the crucial effect of human microbiota on various perspectives of health and disease, which include cancer. The oral-gut microbiome axis, pa...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2024.1413266/full |
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| author | Lan Huang Chun Jiang Meina Yan Weimin Wan Shuxiang Li Ze Xiang Jian Wu |
| author_facet | Lan Huang Chun Jiang Meina Yan Weimin Wan Shuxiang Li Ze Xiang Jian Wu |
| author_sort | Lan Huang |
| collection | DOAJ |
| description | As a complicated and heterogeneous condition, breast cancer (BC) has posed a tremendous public health challenge across the world. Recent studies have uncovered the crucial effect of human microbiota on various perspectives of health and disease, which include cancer. The oral-gut microbiome axis, particularly, have been implicated in the occurrence and development of colorectal cancer through their intricate interactions with host immune system and modulation of systemic inflammation. However, the research concerning the impact of oral-gut microbiome axis on BC remains scarce. This study focused on comprehensively reviewing and summarizing the latest ideas about the potential bidirectional relation of the gut with oral microbiota in BC, emphasizing their potential impact on tumorigenesis, treatment response, and overall patient outcomes. This review can reveal the prospect of tumor microecology and propose a novel viewpoint that the oral-gut microbiome axis can be a breakthrough point in future BC studies. |
| format | Article |
| id | doaj-art-d9213873b9d04e71afedf9653683c3d0 |
| institution | Kabale University |
| issn | 2235-2988 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj-art-d9213873b9d04e71afedf9653683c3d02024-11-21T06:23:40ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882024-11-011410.3389/fcimb.2024.14132661413266The oral-gut microbiome axis in breast cancer: from basic research to therapeutic applicationsLan Huang0Chun Jiang1Meina Yan2Weimin Wan3Shuxiang Li4Ze Xiang5Jian Wu6Department of Clinical Laboratory, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, Jiangsu, ChinaDepartment of Clinical Laboratory, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, Jiangsu, ChinaDepartment of Clinical Laboratory, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, Jiangsu, ChinaDepartment of Clinical Laboratory, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, Jiangsu, ChinaDepartment of Clinical Laboratory, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, Jiangsu, ChinaZhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaDepartment of Clinical Laboratory, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, Jiangsu, ChinaAs a complicated and heterogeneous condition, breast cancer (BC) has posed a tremendous public health challenge across the world. Recent studies have uncovered the crucial effect of human microbiota on various perspectives of health and disease, which include cancer. The oral-gut microbiome axis, particularly, have been implicated in the occurrence and development of colorectal cancer through their intricate interactions with host immune system and modulation of systemic inflammation. However, the research concerning the impact of oral-gut microbiome axis on BC remains scarce. This study focused on comprehensively reviewing and summarizing the latest ideas about the potential bidirectional relation of the gut with oral microbiota in BC, emphasizing their potential impact on tumorigenesis, treatment response, and overall patient outcomes. This review can reveal the prospect of tumor microecology and propose a novel viewpoint that the oral-gut microbiome axis can be a breakthrough point in future BC studies.https://www.frontiersin.org/articles/10.3389/fcimb.2024.1413266/fulloral-gut microbiome axisgut microbiotaoral microbiotaBCtumor microecology |
| spellingShingle | Lan Huang Chun Jiang Meina Yan Weimin Wan Shuxiang Li Ze Xiang Jian Wu The oral-gut microbiome axis in breast cancer: from basic research to therapeutic applications Frontiers in Cellular and Infection Microbiology oral-gut microbiome axis gut microbiota oral microbiota BC tumor microecology |
| title | The oral-gut microbiome axis in breast cancer: from basic research to therapeutic applications |
| title_full | The oral-gut microbiome axis in breast cancer: from basic research to therapeutic applications |
| title_fullStr | The oral-gut microbiome axis in breast cancer: from basic research to therapeutic applications |
| title_full_unstemmed | The oral-gut microbiome axis in breast cancer: from basic research to therapeutic applications |
| title_short | The oral-gut microbiome axis in breast cancer: from basic research to therapeutic applications |
| title_sort | oral gut microbiome axis in breast cancer from basic research to therapeutic applications |
| topic | oral-gut microbiome axis gut microbiota oral microbiota BC tumor microecology |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2024.1413266/full |
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