Ion-Pair Complex of Trimethoprim with Alizarin Yellow and its Determination and Extraction by LLE and DLLME
For the analysis of trimethoprim medication in its pure form and pharmaceutical formulations, precise and accurate microextraction techniques with UV-Vis measurement have been developed and confirmed. In this study, LLE and DLLME procedures were utilized for the separation, pre-concentration, and e...
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| Language: | English |
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Tikrit University
2023-06-01
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| Series: | Tikrit Journal of Pure Science |
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| Online Access: | https://tjpsj.org/index.php/tjps/article/view/1422 |
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| author | Araf I. Jabbar Mohammed Z. Thani Ali I. Khaleel |
| author_facet | Araf I. Jabbar Mohammed Z. Thani Ali I. Khaleel |
| author_sort | Araf I. Jabbar |
| collection | DOAJ |
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For the analysis of trimethoprim medication in its pure form and pharmaceutical formulations, precise and accurate microextraction techniques with UV-Vis measurement have been developed and confirmed. In this study, LLE and DLLME procedures were utilized for the separation, pre-concentration, and evaluation of trimethoprim in pure form and pharmaceutical preparations by UV-Vis spectroscopy at 390 nm. The method was validated and applied to the evaluation of trimethoprim in pharmaceutical formulations. Several experimental factors containing the type of dispersive and extraction solvents and their volumes, pH, temperature, and centrifuging time were carried out. Under the ideal conditions, the procedures were linear in the range of 2–45 and 1-10 mg/L, with a coefficient of determination (R2) of 0.9961 and 0.9992 for LLE and DLLME, respectively. The limit of detection (LOD) was 1.52 and 0.21 mg/L. Recovery of the target analyte in pharmaceutical formulations was 99.3%-104.9%.
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| format | Article |
| id | doaj-art-d9208c2a0f4c42d08fa9bb81d3b7c9b4 |
| institution | Kabale University |
| issn | 1813-1662 2415-1726 |
| language | English |
| publishDate | 2023-06-01 |
| publisher | Tikrit University |
| record_format | Article |
| series | Tikrit Journal of Pure Science |
| spelling | doaj-art-d9208c2a0f4c42d08fa9bb81d3b7c9b42025-08-20T03:50:20ZengTikrit UniversityTikrit Journal of Pure Science1813-16622415-17262023-06-0128310.25130/tjps.v28i3.1422Ion-Pair Complex of Trimethoprim with Alizarin Yellow and its Determination and Extraction by LLE and DLLMEAraf I. JabbarMohammed Z. ThaniAli I. Khaleel For the analysis of trimethoprim medication in its pure form and pharmaceutical formulations, precise and accurate microextraction techniques with UV-Vis measurement have been developed and confirmed. In this study, LLE and DLLME procedures were utilized for the separation, pre-concentration, and evaluation of trimethoprim in pure form and pharmaceutical preparations by UV-Vis spectroscopy at 390 nm. The method was validated and applied to the evaluation of trimethoprim in pharmaceutical formulations. Several experimental factors containing the type of dispersive and extraction solvents and their volumes, pH, temperature, and centrifuging time were carried out. Under the ideal conditions, the procedures were linear in the range of 2–45 and 1-10 mg/L, with a coefficient of determination (R2) of 0.9961 and 0.9992 for LLE and DLLME, respectively. The limit of detection (LOD) was 1.52 and 0.21 mg/L. Recovery of the target analyte in pharmaceutical formulations was 99.3%-104.9%. https://tjpsj.org/index.php/tjps/article/view/1422TrimethoprimIon-pair complexliquid-liquid extraction (LLE)dispersive liquid-liquid extraction (DLLME)Microextraction |
| spellingShingle | Araf I. Jabbar Mohammed Z. Thani Ali I. Khaleel Ion-Pair Complex of Trimethoprim with Alizarin Yellow and its Determination and Extraction by LLE and DLLME Tikrit Journal of Pure Science Trimethoprim Ion-pair complex liquid-liquid extraction (LLE) dispersive liquid-liquid extraction (DLLME) Microextraction |
| title | Ion-Pair Complex of Trimethoprim with Alizarin Yellow and its Determination and Extraction by LLE and DLLME |
| title_full | Ion-Pair Complex of Trimethoprim with Alizarin Yellow and its Determination and Extraction by LLE and DLLME |
| title_fullStr | Ion-Pair Complex of Trimethoprim with Alizarin Yellow and its Determination and Extraction by LLE and DLLME |
| title_full_unstemmed | Ion-Pair Complex of Trimethoprim with Alizarin Yellow and its Determination and Extraction by LLE and DLLME |
| title_short | Ion-Pair Complex of Trimethoprim with Alizarin Yellow and its Determination and Extraction by LLE and DLLME |
| title_sort | ion pair complex of trimethoprim with alizarin yellow and its determination and extraction by lle and dllme |
| topic | Trimethoprim Ion-pair complex liquid-liquid extraction (LLE) dispersive liquid-liquid extraction (DLLME) Microextraction |
| url | https://tjpsj.org/index.php/tjps/article/view/1422 |
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