Alone or in combination, hyaluronic acid and chondroitin sulfate alleviate ECM degradation in osteoarthritis by inhibiting the NF-κB pathway

Alone or in combination, hyaluronic acid and chondroitin sulfate alleviate ECM degradation in osteoarthritis by inhibiting the NF-κB pathway

Abstract Backgrounds Osteoarthritis (OA) significantly impacts the elderly, leading to disability and decreased quality of life. While hyaluronic acid (HA) and chondroitin sulfate (CS) are recognized for their therapeutic potential in OA, their effects on extracellular matrix (ECM) degradation are n...

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Bibliographic Details
Main Authors: Yiran Ma, Xin Yang, Min Jiang, Wangjuan Ye, Hong Qin, Songwen Tan
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Hyaluronic acid
Chondroitin sulfate
NF-κB
Osteoarthritis
Extracellular matrix
Online Access:https://doi.org/10.1186/s13018-024-05411-6
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