Prognostic accuracy of Whole Lung Perfusion Blood Volume as a predictor of 28-day Mortality in Acute Pulmonary Thromboembolism – A prospective study
Background: The estimated incidence of pulmonary embolism (PE) is around 60–70 cases per 100,000 people annually. The overall mortality rate for massive PE is substantial, ranging from 18% to 65%. We can utilise changes in lung perfusion to stratify patients with PE acutely based on risk, highlighti...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-01-01
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| Series: | Lung India |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/lungindia.lungindia_185_24 |
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| Summary: | Background:
The estimated incidence of pulmonary embolism (PE) is around 60–70 cases per 100,000 people annually. The overall mortality rate for massive PE is substantial, ranging from 18% to 65%. We can utilise changes in lung perfusion to stratify patients with PE acutely based on risk, highlighting its diagnostic and prognostic value.
Objectives:
To calculate the whole-lung perfused blood volume (PBV) and right-to-left ventricular diameter ratio from dual-energy computed tomography thorax in patients with acute PE and find its association with 28-day all-cause mortality.
Methods:
This was a prospective diagnostic accuracy study at the Jawaharlal Institute of Post-Graduate Medical Education and Research. We included suspected acute PE patients. A dual-energy chest CT was performed on all these patients, and iodine maps were generated using the Syngo dual-energy workstation. Whole-lung PBVs were then calculated. Patients were followed up for 28 days, and all-cause mortality data were collected. The prognostic accuracy of PBVs in predicting mortality among acute PE patients was analysed using the ROC curve using SPSS version 19.0.
Results:
The area under the curve (AUC) was 0.696, indicating a moderate discriminatory power in distinguishing between patients who experienced mortality and those who did not. An empirical cut-off value of 0.945 corresponds to a sensitivity of 63.2% and a specificity of 67.6%.
Conclusion:
The prognostic accuracy of total perfused lung volume/total lung volume revealed a moderate discriminatory power, indicating 70% accuracy in predicting 28-day mortality based on standardised total PBVs. |
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| ISSN: | 0970-2113 0974-598X |