Progress in the Application of Organoids-On-A-Chip in Diseases
With the rapid development of the field of life sciences, traditional 2D cell culture and animal models have long been unable to meet the urgent needs of modern biomedical research and new drug development. Establishing a new generation of experimental models and research models is of great signific...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2024-12-01
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| Series: | Organogenesis |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/15476278.2024.2386727 |
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| _version_ | 1846119874140569600 |
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| author | Qiao Geng Yanyan Xu Yang Hu Lu Wang Yi Wang Zhimin Fan Desong Kong |
| author_facet | Qiao Geng Yanyan Xu Yang Hu Lu Wang Yi Wang Zhimin Fan Desong Kong |
| author_sort | Qiao Geng |
| collection | DOAJ |
| description | With the rapid development of the field of life sciences, traditional 2D cell culture and animal models have long been unable to meet the urgent needs of modern biomedical research and new drug development. Establishing a new generation of experimental models and research models is of great significance for deeply understanding human health and disease processes, and developing effective treatment measures. As is well known, long research and development cycles, high risks, and high costs are the “three mountains” facing the development of new drugs today. Organoids and organ-on-chips technology can highly simulate and reproduce the human physiological environment and complex reactions in vitro, greatly improving the accuracy of drug clinical efficacy prediction, reducing drug development costs, and avoiding the defects of drug testing animal models. Therefore, organ-on-chips have enormous potential in medical diagnosis and treatment. |
| format | Article |
| id | doaj-art-d8c99d0494e64d79a3676cbe29bfb02c |
| institution | Kabale University |
| issn | 1547-6278 1555-8592 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Organogenesis |
| spelling | doaj-art-d8c99d0494e64d79a3676cbe29bfb02c2024-12-16T16:20:17ZengTaylor & Francis GroupOrganogenesis1547-62781555-85922024-12-0120110.1080/15476278.2024.2386727Progress in the Application of Organoids-On-A-Chip in DiseasesQiao Geng0Yanyan Xu1Yang Hu2Lu Wang3Yi Wang4Zhimin Fan5Desong Kong6Chinese Medicine Modernization and Big Data Research Center, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, ChinaDepartment of Anoenterology, Nanjing Hospital of Chinese Medicine affiliated to Nanjing University of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, ChinaChinese Medicine Modernization and Big Data Research Center, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, ChinaDepartment of colorectal surgery, The Second Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, ChinaDepartment of colorectal surgery, The Second Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, ChinaDepartment of colorectal surgery, The Second Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, ChinaChinese Medicine Modernization and Big Data Research Center, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, ChinaWith the rapid development of the field of life sciences, traditional 2D cell culture and animal models have long been unable to meet the urgent needs of modern biomedical research and new drug development. Establishing a new generation of experimental models and research models is of great significance for deeply understanding human health and disease processes, and developing effective treatment measures. As is well known, long research and development cycles, high risks, and high costs are the “three mountains” facing the development of new drugs today. Organoids and organ-on-chips technology can highly simulate and reproduce the human physiological environment and complex reactions in vitro, greatly improving the accuracy of drug clinical efficacy prediction, reducing drug development costs, and avoiding the defects of drug testing animal models. Therefore, organ-on-chips have enormous potential in medical diagnosis and treatment.https://www.tandfonline.com/doi/10.1080/15476278.2024.2386727Disease modelmicrofluidicslorgan-on-a-chiporganoid |
| spellingShingle | Qiao Geng Yanyan Xu Yang Hu Lu Wang Yi Wang Zhimin Fan Desong Kong Progress in the Application of Organoids-On-A-Chip in Diseases Organogenesis Disease model microfluidics lorgan-on-a-chip organoid |
| title | Progress in the Application of Organoids-On-A-Chip in Diseases |
| title_full | Progress in the Application of Organoids-On-A-Chip in Diseases |
| title_fullStr | Progress in the Application of Organoids-On-A-Chip in Diseases |
| title_full_unstemmed | Progress in the Application of Organoids-On-A-Chip in Diseases |
| title_short | Progress in the Application of Organoids-On-A-Chip in Diseases |
| title_sort | progress in the application of organoids on a chip in diseases |
| topic | Disease model microfluidics lorgan-on-a-chip organoid |
| url | https://www.tandfonline.com/doi/10.1080/15476278.2024.2386727 |
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