Potassium binding by carbonyl clusters, halophilic adaptation and catalysis of Haloferax mediterranei D-2-hydroxyacid dehydrogenase

Potassium binding by carbonyl clusters, halophilic adaptation and catalysis of Haloferax mediterranei D-2-hydroxyacid dehydrogenase

Abstract Enzymes from salt-in halophiles are stable in conditions of low water activity with applications in chiral synthesis requiring organic solvents, yet the origins of such stability remains poorly understood. Here we describe the molecular basis of the reaction mechanism and dual NADH/NADPH-sp...

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Main Authors: Jessica Domenech, Nuttawan Pramanpol, Claudine Bisson, Sveta E. Sedelnikova, Joshua R. Barrett, Abdul A. A. B. Dakhil, Vitaliy Mykhaylyk, Ali S. Abdelhameed, Stephen E. Harding, David W. Rice, Patrick J. Baker, Juan Ferrer
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08587-7
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https://doi.org/10.1038/s42003-025-08587-7

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