Therapeutical properties of apigenin: a review on the experimental evidence and basic mechanisms
Apigenin (4,’5,7-trihydroxyflavone) is one of the most studied flavonoids with low toxicity and abundantly present phenolic compound in the plant kingdom. The main sources of apigenin are fruits, vegetables, nuts, herbs, honey, and plant-based drinks like tea. Numerous plants produce apigenin as a s...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-09-01
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| Series: | International Journal of Food Properties |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/10942912.2023.2236329 |
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| author | Zarina Mushtaq Nabeelah Bibi Sadeer Muzzamal Hussain Mahwish Suliman A. Alsagaby Muhammad Imran Tamseela Mumtaz Maryam Umar Ambreen Tauseef Waleed Al Abdulmonem Tabussam Tufail Entessar Al Jbawi Mohamad Fawzi Mahomoodally |
| author_facet | Zarina Mushtaq Nabeelah Bibi Sadeer Muzzamal Hussain Mahwish Suliman A. Alsagaby Muhammad Imran Tamseela Mumtaz Maryam Umar Ambreen Tauseef Waleed Al Abdulmonem Tabussam Tufail Entessar Al Jbawi Mohamad Fawzi Mahomoodally |
| author_sort | Zarina Mushtaq |
| collection | DOAJ |
| description | Apigenin (4,’5,7-trihydroxyflavone) is one of the most studied flavonoids with low toxicity and abundantly present phenolic compound in the plant kingdom. The main sources of apigenin are fruits, vegetables, nuts, herbs, honey, and plant-based drinks like tea. Numerous plants produce apigenin as a secondary metabolite and its intake is strongly related to its anti-inflammatory propensities. The purpose of present review was to wade through the literature on the anti-inflammatory mechanisms of this metabolite in various diseases and summarize the key objectives as they appear. Existing literature reported that apigenin is a promising candidate in managing a panoply of inflammatory-related diseases including cancer, diabetes, obesity, depression, insomnia, infection, and respiratory, cardiovascular, hepatoprotective, neurodegenerative, and skin diseases. Studies showed that apigenin significantly decreases the secretion of various proinflammatory cytokines specifically tumor necrosis factor (TNF)-α, IL-1β, IL-6, and IL-10. Moreover, apigenin effectively blocks the nitric oxide-mediated cyclooxygenase-2 expression and monocyte attachment and Prostaglandin by lowering iNOS and COX-2 in both microglial and macrophage mouse cells. Apigenin can slow the course of nonalcoholic fatty liver disease (NAFLD) in vivo by reducing high fat diet (HFD)-induced deposition of lipids and oxidative stress. It also controlled redox imbalances, suppress neuronal death and showed memory enhancement/learning skills and a reduction of fibrillar amyloid deposits with lowered insoluble Aβ concentrations in vivo. Taken together, it can be argued that apigenin can wane inflammation and thus offers a promising future in slowing down the development of chronic diseases and associated complications. |
| format | Article |
| id | doaj-art-d8b89b4565fd481eb2a71e97d5c3832f |
| institution | Kabale University |
| issn | 1094-2912 1532-2386 |
| language | English |
| publishDate | 2023-09-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Food Properties |
| spelling | doaj-art-d8b89b4565fd481eb2a71e97d5c3832f2025-01-02T10:41:35ZengTaylor & Francis GroupInternational Journal of Food Properties1094-29121532-23862023-09-012611914193910.1080/10942912.2023.2236329Therapeutical properties of apigenin: a review on the experimental evidence and basic mechanismsZarina Mushtaq0Nabeelah Bibi Sadeer1Muzzamal Hussain2Mahwish3Suliman A. Alsagaby4Muhammad Imran5Tamseela Mumtaz6Maryam Umar7Ambreen Tauseef8Waleed Al Abdulmonem9Tabussam Tufail10Entessar Al Jbawi11Mohamad Fawzi Mahomoodally12Department of Food Science, Government College University Faisalabad, Faisalabad, PakistanDepartment of Health Sciences, Faculty of Medicine and Health Sciences, University of Mauritius, Réduit, MauritiusDepartment of Food Science, Government College University Faisalabad, Faisalabad, PakistanDepartment of Nutritional Sciences, Government College Women University, Faisalabad, PakistanDepartment of Medical Laboratory Sciences, College of Applied Medical Sciences, Majmaah University, AL-Majmaah, Saudi ArabiaDepartment of Food Science and Technology, University of Narowal, Narowal, PakistanDepartment of Zoology, Government College Women University Faisalabad, Faisalabad, PakistanDepartment of Food Science, Government College University Faisalabad, Faisalabad, PakistanDepartment of Physiology, CMH, Lahore, PakistanDepartment of Pathology, College of Medicine, Qassim University, Buraidah, Saudi ArabiaInstitute of Diet & Nutritional Sciences, The University of Lahore, Lahore, PakistanAgricultural Extension Directorate, MAAR, Damascus, SyriaDepartment of Health Sciences, Faculty of Medicine and Health Sciences, University of Mauritius, Réduit, MauritiusApigenin (4,’5,7-trihydroxyflavone) is one of the most studied flavonoids with low toxicity and abundantly present phenolic compound in the plant kingdom. The main sources of apigenin are fruits, vegetables, nuts, herbs, honey, and plant-based drinks like tea. Numerous plants produce apigenin as a secondary metabolite and its intake is strongly related to its anti-inflammatory propensities. The purpose of present review was to wade through the literature on the anti-inflammatory mechanisms of this metabolite in various diseases and summarize the key objectives as they appear. Existing literature reported that apigenin is a promising candidate in managing a panoply of inflammatory-related diseases including cancer, diabetes, obesity, depression, insomnia, infection, and respiratory, cardiovascular, hepatoprotective, neurodegenerative, and skin diseases. Studies showed that apigenin significantly decreases the secretion of various proinflammatory cytokines specifically tumor necrosis factor (TNF)-α, IL-1β, IL-6, and IL-10. Moreover, apigenin effectively blocks the nitric oxide-mediated cyclooxygenase-2 expression and monocyte attachment and Prostaglandin by lowering iNOS and COX-2 in both microglial and macrophage mouse cells. Apigenin can slow the course of nonalcoholic fatty liver disease (NAFLD) in vivo by reducing high fat diet (HFD)-induced deposition of lipids and oxidative stress. It also controlled redox imbalances, suppress neuronal death and showed memory enhancement/learning skills and a reduction of fibrillar amyloid deposits with lowered insoluble Aβ concentrations in vivo. Taken together, it can be argued that apigenin can wane inflammation and thus offers a promising future in slowing down the development of chronic diseases and associated complications.https://www.tandfonline.com/doi/10.1080/10942912.2023.2236329Apigenincancerflavonoidsoxidative stresschronic diseasesbioactive compounds |
| spellingShingle | Zarina Mushtaq Nabeelah Bibi Sadeer Muzzamal Hussain Mahwish Suliman A. Alsagaby Muhammad Imran Tamseela Mumtaz Maryam Umar Ambreen Tauseef Waleed Al Abdulmonem Tabussam Tufail Entessar Al Jbawi Mohamad Fawzi Mahomoodally Therapeutical properties of apigenin: a review on the experimental evidence and basic mechanisms International Journal of Food Properties Apigenin cancer flavonoids oxidative stress chronic diseases bioactive compounds |
| title | Therapeutical properties of apigenin: a review on the experimental evidence and basic mechanisms |
| title_full | Therapeutical properties of apigenin: a review on the experimental evidence and basic mechanisms |
| title_fullStr | Therapeutical properties of apigenin: a review on the experimental evidence and basic mechanisms |
| title_full_unstemmed | Therapeutical properties of apigenin: a review on the experimental evidence and basic mechanisms |
| title_short | Therapeutical properties of apigenin: a review on the experimental evidence and basic mechanisms |
| title_sort | therapeutical properties of apigenin a review on the experimental evidence and basic mechanisms |
| topic | Apigenin cancer flavonoids oxidative stress chronic diseases bioactive compounds |
| url | https://www.tandfonline.com/doi/10.1080/10942912.2023.2236329 |
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