P-Body Components, microRNA Regulation, and Synaptic Plasticity
What is the protein apparatus required for microRNA (miRNA) function and translational repression in neurons? This article reviews our recent work on Me31B, a conserved P-body protein present on Staufen-containing neuronal and maternal ribonucleoprotein (RNP) particles, which is required for dendrit...
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| Format: | Article |
| Language: | English |
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Wiley
2007-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2007.206 |
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| _version_ | 1841524421677809664 |
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| author | Jens Hillebrand Scott A. Barbee Mani Ramaswami |
| author_facet | Jens Hillebrand Scott A. Barbee Mani Ramaswami |
| author_sort | Jens Hillebrand |
| collection | DOAJ |
| description | What is the protein apparatus required for microRNA (miRNA) function and translational repression in neurons? This article reviews our recent work on Me31B, a conserved P-body protein present on Staufen-containing neuronal and maternal ribonucleoprotein (RNP) particles, which is required for dendrite morphogenesis and miRNA function in vivo. In addition, it provides new data to show that Me31B is present on and regulates formation of P-bodies in the Drosophila wing disc, where it has a general role in the regulation of miRNA function. While illuminating the function of this important RNA regulatory molecule, it also brings into focus a hypothesis of potentially broad significance. Namely, that P-body proteins may play important roles in regulation of dendrite-localized mRNAs and, thereby, in synaptic plasticity. A wide range of protein localization and early functional data support this hypothesis. We also discuss current knowledge of RNP particles that mediate translational repression and the implications of these findings for understanding translational control in neurons. |
| format | Article |
| id | doaj-art-d8aff1757c9c4dc49bfc66d2a0295554 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2007-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-d8aff1757c9c4dc49bfc66d2a02955542025-02-03T05:53:22ZengWileyThe Scientific World Journal1537-744X2007-01-01717819010.1100/tsw.2007.206P-Body Components, microRNA Regulation, and Synaptic PlasticityJens Hillebrand0Scott A. Barbee1Mani Ramaswami2Smurfit Institute of Genetics and TCIN, Lloyd Building, Trinity College Dublin, Dublin-2, IrelandDepartment of Molecular and Cellular Biology, University of Arizona, Tucson, AZ 85721, USASmurfit Institute of Genetics and TCIN, Lloyd Building, Trinity College Dublin, Dublin-2, IrelandWhat is the protein apparatus required for microRNA (miRNA) function and translational repression in neurons? This article reviews our recent work on Me31B, a conserved P-body protein present on Staufen-containing neuronal and maternal ribonucleoprotein (RNP) particles, which is required for dendrite morphogenesis and miRNA function in vivo. In addition, it provides new data to show that Me31B is present on and regulates formation of P-bodies in the Drosophila wing disc, where it has a general role in the regulation of miRNA function. While illuminating the function of this important RNA regulatory molecule, it also brings into focus a hypothesis of potentially broad significance. Namely, that P-body proteins may play important roles in regulation of dendrite-localized mRNAs and, thereby, in synaptic plasticity. A wide range of protein localization and early functional data support this hypothesis. We also discuss current knowledge of RNP particles that mediate translational repression and the implications of these findings for understanding translational control in neurons.http://dx.doi.org/10.1100/tsw.2007.206 |
| spellingShingle | Jens Hillebrand Scott A. Barbee Mani Ramaswami P-Body Components, microRNA Regulation, and Synaptic Plasticity The Scientific World Journal |
| title | P-Body Components, microRNA Regulation, and Synaptic Plasticity |
| title_full | P-Body Components, microRNA Regulation, and Synaptic Plasticity |
| title_fullStr | P-Body Components, microRNA Regulation, and Synaptic Plasticity |
| title_full_unstemmed | P-Body Components, microRNA Regulation, and Synaptic Plasticity |
| title_short | P-Body Components, microRNA Regulation, and Synaptic Plasticity |
| title_sort | p body components microrna regulation and synaptic plasticity |
| url | http://dx.doi.org/10.1100/tsw.2007.206 |
| work_keys_str_mv | AT jenshillebrand pbodycomponentsmicrornaregulationandsynapticplasticity AT scottabarbee pbodycomponentsmicrornaregulationandsynapticplasticity AT maniramaswami pbodycomponentsmicrornaregulationandsynapticplasticity |