Virgin coconut oil prevents airway remodeling and recovers tracheal relaxing reactivity by reducing transforming growth factor β expression on asthmatic guinea pig
Asthma is a chronic inflammatory disease with many patients failing to respond appropriately to pharmacotherapy. Thus, virgin coconut oil (VCO) can be an alternative therapy. Guinea pigs were divided into control (Ctrl), chronic allergic lung inflammation (Asth), Asth treated with dexamethasone (Ast...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-11-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464624005462 |
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| author | Luiz Henrique César Vasconcelos Maria da Conceição Correia Silva Alana Cristina Costa Giuliana Amanda de Oliveira Iara Leão Luna de Souza Rubens da Silva Araújo Adriano Francisco Alves Fabiana de Andrade Cavalcante Bagnólia Araújo da Silva |
| author_facet | Luiz Henrique César Vasconcelos Maria da Conceição Correia Silva Alana Cristina Costa Giuliana Amanda de Oliveira Iara Leão Luna de Souza Rubens da Silva Araújo Adriano Francisco Alves Fabiana de Andrade Cavalcante Bagnólia Araújo da Silva |
| author_sort | Luiz Henrique César Vasconcelos |
| collection | DOAJ |
| description | Asthma is a chronic inflammatory disease with many patients failing to respond appropriately to pharmacotherapy. Thus, virgin coconut oil (VCO) can be an alternative therapy. Guinea pigs were divided into control (Ctrl), chronic allergic lung inflammation (Asth), Asth treated with dexamethasone (Asth + dexa), and Asth supplemented with VCO (Asth + VCO4). The tested animals were sensitized and challenged with ovalbumin. Relaxation induced by arachidonic acid (AA) was impaired in Asth, and this reduction was prevented by VCO (p = 0.0004), indicating formation of relaxing prostanoids, or the decrease of cysteinyl-leukotrienes by VCO. Furthermore, a possible negative modulation of β receptors/BKCa pathway by TGF–β in Asth was prevented by VCO (p = 0.0073). Finally, in Asth, Masson’s trichrome staining revealed airway remodeling and immunohistochemistry showed increased TGF-β expression in the lungs of Asth (p < 0.0001)), which was prevented by VCO and dexamethasone (p < 0.0001), concluding VCO as a possible agent against asthma. |
| format | Article |
| id | doaj-art-d8a8622fc9ef40a1b569b8eb0acb0ac5 |
| institution | Kabale University |
| issn | 1756-4646 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj-art-d8a8622fc9ef40a1b569b8eb0acb0ac52024-11-16T05:10:53ZengElsevierJournal of Functional Foods1756-46462024-11-01122106544Virgin coconut oil prevents airway remodeling and recovers tracheal relaxing reactivity by reducing transforming growth factor β expression on asthmatic guinea pigLuiz Henrique César Vasconcelos0Maria da Conceição Correia Silva1Alana Cristina Costa2Giuliana Amanda de Oliveira3Iara Leão Luna de Souza4Rubens da Silva Araújo5Adriano Francisco Alves6Fabiana de Andrade Cavalcante7Bagnólia Araújo da Silva8Laboratório de Farmacologia Funcional Professor George Thomas, Instituto de Pesquisa em Fármacos e Medicamentos, Universidade Federal da Paraíba, João Pessoa/PB, Brazil; Programa de Pós-graduação em Produtos Naturais e Sintéticos Bioativos, Centro de Ciências da Saúde, Universidade Federal da Paraíba, João Pessoa/PB, Brazil; Departamento de Fisiologia e Patologia, Centro de Ciências da Saúde, Universidade Federal da Paraíba, João Pessoa/PB, Brazil; Corresponding author at: Laboratório de Farmacologia Funcional Prof. George Thomas, Instituto de Pesquisa em Fármacos e Medicamentos, Universidade Federal da Paraíba, Cidade Universitária, João Pessoa/PB, Zip Code 58.051970, P.O. Box 5009, Brazil.Postdoc Conselho Nacional de Desenvolvimento Científico e Tecnológico/Fundação de Amparo a Ciência e Tecnologia de Pernambuco, BrazilLaboratório de Farmacologia Funcional Professor George Thomas, Instituto de Pesquisa em Fármacos e Medicamentos, Universidade Federal da Paraíba, João Pessoa/PB, BrazilLaboratório de Farmacologia Funcional Professor George Thomas, Instituto de Pesquisa em Fármacos e Medicamentos, Universidade Federal da Paraíba, João Pessoa/PB, BrazilLaboratório de Farmacologia Funcional Professor George Thomas, Instituto de Pesquisa em Fármacos e Medicamentos, Universidade Federal da Paraíba, João Pessoa/PB, BrazilPrograma de Pós-graduação em Produtos Naturais e Sintéticos Bioativos, Centro de Ciências da Saúde, Universidade Federal da Paraíba, João Pessoa/PB, BrazilPrograma de Pós-graduação em Produtos Naturais e Sintéticos Bioativos, Centro de Ciências da Saúde, Universidade Federal da Paraíba, João Pessoa/PB, Brazil; Departamento de Fisiologia e Patologia, Centro de Ciências da Saúde, Universidade Federal da Paraíba, João Pessoa/PB, BrazilLaboratório de Farmacologia Funcional Professor George Thomas, Instituto de Pesquisa em Fármacos e Medicamentos, Universidade Federal da Paraíba, João Pessoa/PB, Brazil; Programa de Pós-graduação em Produtos Naturais e Sintéticos Bioativos, Centro de Ciências da Saúde, Universidade Federal da Paraíba, João Pessoa/PB, Brazil; Departamento de Fisiologia e Patologia, Centro de Ciências da Saúde, Universidade Federal da Paraíba, João Pessoa/PB, BrazilLaboratório de Farmacologia Funcional Professor George Thomas, Instituto de Pesquisa em Fármacos e Medicamentos, Universidade Federal da Paraíba, João Pessoa/PB, Brazil; Programa de Pós-graduação em Produtos Naturais e Sintéticos Bioativos, Centro de Ciências da Saúde, Universidade Federal da Paraíba, João Pessoa/PB, Brazil; Departamento de Ciências Farmacêuticas, Centro de Ciências da Saúde, Universidade Federal da Paraíba, João Pessoa/PB, BrazilAsthma is a chronic inflammatory disease with many patients failing to respond appropriately to pharmacotherapy. Thus, virgin coconut oil (VCO) can be an alternative therapy. Guinea pigs were divided into control (Ctrl), chronic allergic lung inflammation (Asth), Asth treated with dexamethasone (Asth + dexa), and Asth supplemented with VCO (Asth + VCO4). The tested animals were sensitized and challenged with ovalbumin. Relaxation induced by arachidonic acid (AA) was impaired in Asth, and this reduction was prevented by VCO (p = 0.0004), indicating formation of relaxing prostanoids, or the decrease of cysteinyl-leukotrienes by VCO. Furthermore, a possible negative modulation of β receptors/BKCa pathway by TGF–β in Asth was prevented by VCO (p = 0.0073). Finally, in Asth, Masson’s trichrome staining revealed airway remodeling and immunohistochemistry showed increased TGF-β expression in the lungs of Asth (p < 0.0001)), which was prevented by VCO and dexamethasone (p < 0.0001), concluding VCO as a possible agent against asthma.http://www.sciencedirect.com/science/article/pii/S1756464624005462AirwaysLung inflammationRelaxing reactivityRemodelingTGF-beta |
| spellingShingle | Luiz Henrique César Vasconcelos Maria da Conceição Correia Silva Alana Cristina Costa Giuliana Amanda de Oliveira Iara Leão Luna de Souza Rubens da Silva Araújo Adriano Francisco Alves Fabiana de Andrade Cavalcante Bagnólia Araújo da Silva Virgin coconut oil prevents airway remodeling and recovers tracheal relaxing reactivity by reducing transforming growth factor β expression on asthmatic guinea pig Journal of Functional Foods Airways Lung inflammation Relaxing reactivity Remodeling TGF-beta |
| title | Virgin coconut oil prevents airway remodeling and recovers tracheal relaxing reactivity by reducing transforming growth factor β expression on asthmatic guinea pig |
| title_full | Virgin coconut oil prevents airway remodeling and recovers tracheal relaxing reactivity by reducing transforming growth factor β expression on asthmatic guinea pig |
| title_fullStr | Virgin coconut oil prevents airway remodeling and recovers tracheal relaxing reactivity by reducing transforming growth factor β expression on asthmatic guinea pig |
| title_full_unstemmed | Virgin coconut oil prevents airway remodeling and recovers tracheal relaxing reactivity by reducing transforming growth factor β expression on asthmatic guinea pig |
| title_short | Virgin coconut oil prevents airway remodeling and recovers tracheal relaxing reactivity by reducing transforming growth factor β expression on asthmatic guinea pig |
| title_sort | virgin coconut oil prevents airway remodeling and recovers tracheal relaxing reactivity by reducing transforming growth factor β expression on asthmatic guinea pig |
| topic | Airways Lung inflammation Relaxing reactivity Remodeling TGF-beta |
| url | http://www.sciencedirect.com/science/article/pii/S1756464624005462 |
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