Mycobacterium tuberculosis bacillus induces pyroptosis in human lung fibroblasts

Mycobacterium tuberculosis bacillus induces pyroptosis in human lung fibroblasts

ABSTRACT We previously reported that live, but not dead, virulent Mycobacterium tuberculosis (Mtb) H37Rv bacilli induce cell death in human lung fibroblast cell lines, MRC-5, MRC-9, and TIG-1. Here, using two distinct Mtb strains from two different lineages (HN878 lineage 2 and H37Rv lineage 4), we...

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Main Authors: Takemasa Takii, Hiroyuki Yamada, Chihiro Motozono, Sho Yamasaki, Jordi B. Torrelles, Joanne Turner, Aoi Kimishima, Yukihiro Asami, Naoya Ohara, Shigeaki Hida, Hidetoshi Hayashi, Kikuo Onozaki
Format: Article
Language:English
Published: American Society for Microbiology 2025-06-01
Series:mSphere
Subjects:
Mycobacterium tuberculosis
pyroptosis
caspase
RNA-Seq
cytokine
fibroblasts
Online Access:https://journals.asm.org/doi/10.1128/msphere.00110-25
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